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In 1999, Fabio Coppedè joined Prof. Lucia Migliore group at the Department of Human and Environmental Sciences of the University of Pisa for the preparation of his Master Degree thesis in Biological Sciences. In that period he worked on oxidative DNA damage and genetic susceptibility to Parkinson’s disease. In 2000, he was the recipient of a “Mobility Grant” from the University of Pisa and had the opportunity to conduct research as academic visitor in Prof. David Collier laboratory, at the Department of Psychiatry of the King's College London, working on genetic susceptibility to Parkinson’s disease for the completion of his Master Degree research project. Back to Italy, he continued his research career in Prof. Lucia Migliore group working respectively as trainee (2001-2002) and Ph.D. student (2002-2005). In those years, he still carried out research on DNA damage in neurodegenerative diseases, but focused his main research activity on the contribution of folate metabolism to cancer and maternal risk of birth of a child with Down syndrome. Particularly, in 2002-2003 he had the opportunity to work as visiting researcher in Prof. Martyn T. Smith group at the School of Public Health of the University of California at Berkeley, where he collaborated to a project aimed at addressing the contribution of polymorphisms in genes of the folate metabolic pathway as risk factors for non-Hodgkin’s lymphoma. After the completion of his Ph.D. program, Dr. Coppedè worked as postdoctoral researcher (2005-2006) in Prof. Maria Eriksson group at the Department of Medical Nutrition of the Karolinska Institutet in Stockholm, where he conducted research on allele-specific gene expression levels in cells of individuals affected by premature aging syndrome. He returned to Italy in 2006 as postdoctoral researcher in Prof. Gabriele Siciliano group at the Department of Neuroscience of the University of Pisa, where he worked until 2010 mainly focusing on genetic susceptibility to neurodegenerative diseases and on genetic risk factors linked to the risk to conceive children with Down syndrome. From 2010 to 2013, Dr. Coppedè worked as a Contract Professor in Genetics and Medical Genetics, at the Faculty of Medicine of the University of Pisa. From 2010 to 2012 he mainly collaborated as Research Fellow to a study of correlation among genetic, epigenetic and environmental factors in colorectal cancer funded by Istituto Toscano Tumori (ITT). At the end of 2011, Dr. Coppedè was the recipient of a Research Grant from the Italian Ministry of Health and gained research independence as Principal Investigator of a project dealing with folate metabolism and epigenetics in Alzheimer's disease, at the Department of Laboratory Medicine of the Pisa University Hospital. From 2013 to October 2015, Dr. Coppedè worked as Fixed term Researcher (RTDa) in Medical Genetics at the Department of Translational Research and New Technologies of the University of Pisa. His research activity was centered on: a) Investigating the contribution of genetic, environmental and epigenetic factors to the risk of cancer, neurodegenerative, and autoimmune diseases. b) Addressing the risk of having a child with Down syndrome related to folate metabolism. c) Addressing the genotoxic and epigenetic hazard linked to the exposure to nanosized materials. Dr. Coppedè was also involved in teaching courses of Medical Genetics. Since October 2015, Dr. Coppedè is an Associate Professor in Medical Genetics at the Department of Translational Research and New Technologies of the University of Pisa. His main research activity is devoted to the discovery of epigenetic biomarkers of human diseases. Particularly, he is currently involved in the study of mitochondrial DNA methylation in neurodegenerative diseases, in the identification of circulating epigenetic biomarkers of amyotrophic lateral sclerosis, in the development and validation of epigenetic biomarkers of colorectal cancer and thoracic neoplasms, as well as in the investigation of epigenetic biomarkers of obesity, autism spectrum disorders, and birth defects. Prof. Coppedè is also involved in an extensive teaching activity in several courses of Medical Genetics, and is currently a member of the Steering Committee of the working group “Epigenetics” of the Italian Society of Human Genetics (SIGU).