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Dr. Loffredo deals with research in atherosclerosis and venous thrombo-embolism; in particular, he carried out research on anticoagulants, cardiovascular drugs, oxidative stress and endothelial dysfunction in several athero-thrombotic diseases (as portal vein thrombosis, peripheral arterial disease, atrial fibrillation, metabolic syndrome, NASH, obstructive sleep apnoea). He has directed and coordinated multi-center studies such as the "AURELIO" multicenter study (rAte of venous thRombosis in acutEly the patIents hOspitalized in internal medicine wards) or in collaboration with IPINET on patients suffering from chronic granulomatous disease.