Evaluating mucosal healing using colon capsule endoscopy predicts outcome in patients with ulcerative colitis in clinical remission

Table 1 Schedule of bowel preparation

Day		Procedure
Previous day	Diet	Low-fibre diet
	After dinner	Magnesium citrate 50 g/180 mL + Sennoside 48 mg
Examination	09:00	Mosapride citrate 20 mg
		Swallowing of CCE-2 capsule
	Booster (1)	1 L of low-volume PEG (MoviPrep) + 0.5 L water
	Booster (2)	1 L of low-volume PEG (MoviPrep) + 0.5 L water
	Booster (3)	Magnesium Citrate 50 g/180 mL

Booster (1): start after capsule moves into small intestine; Booster (2): start 1 h after booster (1); Booster (3): 3 h after booster (1) if capsule is not exhausted. CCE-2: Second generation of colon capsule endoscopy; PEG: Polyethylene glycol.

Table 2 Patients’ characteristics n (%)

Numbers of patients	30
Gender (male/female)	18/12
Age [mean ± SD (range), yr]	48.6 ± 13.3 (24-67)
Disease duration [mean ± SD (range), yr]	13.9 ± 9.5 (1-32)
Inpatient/outpatient	0/30
History of abdominal surgery	2 (6.7)
Type of disease
Total colitis	19 (63.3)
Left-sided	10 (33.3)
Proctitis	1 (3.3)
Disease activity (Rachmilewitz index)
CAI = 0	19 (63.3)
CAI = 1	4 (13.3)
CAI = 2	4 (13.3)
CAI = 3	2 (6.7)
CAI = 4	1 (3.3)
Serum albumin (mean ± SD, g/dL)	4.2 ± 0.5
Serum CRP (mean ± SD, mg/dL)	0.11 ± 0.15
Medications
5-ASA	24 (80.0)
Steroid	4 (13.3)
Thiopurines	12 (40.0)
Anti-TNF-Ab	1 (3.3)
No medication	1 (3.3)
Observation period after CCE; median (range)	20.5 (5-27)

CAI: Clinical activity index; 5-ASA: 5-aminosalicylic acid; SD: Standard deviation; CRP: C-reactive protein; CCE: Colon capsule endoscopy.

Table 3 Performance of second generation of colon capsule endoscopy procedure

Total colon observation1, %	93.3% (28/30)
Excretion within 8 h, %	90.0% (27/30)
Capsule retention rate, %	0% (0/30)
Mean transit time ± SD (range), min
Stomach	27.2 ± 15.4 (4-63)
Small intestine	72.7 ± 34.3 (23-155)
Colon2	163.9 ± 211.0 (9-775)
Cecum and ascending colon	50.4 ± 84.2 (1-386)
Transverse colon	11.7 ± 17.6 (5-80)
Left-side colon2	101.9 ± 186.3 (5-751)
Total time2	263.8 ± 228.2 (54-952)
Total liquid volume of the examination day	2329 ± 854 (500-3180)

¹Excretion before the battery ran down;

²Involving the end point of battery time without excretion.