Review
Copyright ©The Author(s) 2016.
World J Nephrol. Jan 6, 2016; 5(1): 43-52
Published online Jan 6, 2016. doi: 10.5527/wjn.v5.i1.43
Table 1 A summary of the results of isolating stem cells from the adult kidney
SpeciesIsolation methodStem cell markersLocationIncorporation into kidney tubulesRef.
RatLabel retainingProximal tubuleYesMaeshima et al[6]
RatLabel retainingPapillaYesOliver et al[8]
RatSide populationSca-1, CD45Some were derived from bone marrowNoIwatani et al[10]
MouseSide populationSca-1InterstitiumNEHishikawa et al[11]
MouseSide populationSca-1Proximal tubuleYes (rare)Challen et al[12]
HumanMarkerCD133TubulesYesBussolati et al[15]
HumanMarkerCD133, CD24Parietal epithelium in the Bowman's capsuleYesSagrinati et al[16]
MouseMarkerSca-1PapillaYesDekel et al[17]
RatCulturePax2, Oct4Proximal tubuleYesGupta et al[18]
Table 2 Effects of Bone marrow mesenchymal stem cells on renal tissue repair
Origin of stem cellsExperimental modelEffectsRef.
MouseGlycerol-induced AKIDifferentiation into tubular epithelial cellsHerrera et al[22]
MouseCisplatin-induced AKIDifferentiation into tubular epithelial cellsMorigi et al[23]
HumanGlomerulonephropathy induced by anti-mesangial cell serumDifferentiation into mesangial cellsWong et al[30]
RatI/R injuryRecovery of renal functionLange et al[24]
No transdifferentiation into tubules
HumanCisplatin-induced AKIRecovery of renal functionMorigi et al[25]
Improved survival
No transdifferentiation into tubules
RatGentamicin-induced AKIRecovery of renal functionReis et al[26]
Conditioned medium and exosomes were effective
RatAdriamycin-induced nephropathyReduced podocyte injuryZoja et al[27]
Increased VEGF production
RatThy1.1 GNReduced mesangiolysisKunter et al[28]
Increased glomerular cell proliferation
Reduced proteinuria
Production of VEGF and TGF-β
MouseCKD (Deficiency in collagen type IV, α-3 chain)Reduced fibrosisNinichuk et al[29]
Production of VEGF and BMP-7
Rat5/6 nephrectomyImproved renal functionSemedo et al[31]
Reduced fibrosis
Reduced expression of IL-6 and TNF-α
RatKidney allograftImproved renal functionFranquesa et al[32]
Reduced fibrosis
Reduced expression of IL-6
Table 3 Effects of adipose tissue-derived mesenchymal stem cells on renal tissue repair
Origin of stem cellsExperimental modelEffectsReferences
RatI/R injuryRecovery of renal functionChen et al[40]
Reduction in oxidative stress
HumanCisplatin-induced AKIRecovery of renal functionKim et al[41]
Conditioned medium was effective
HumanFolic acid-induced AKIRecovery of renal functionKatsuno et al[42]
HGF and VEGF production
RatAnti-GBM diseaseReduced renal injury and proteinuriaFuruhashi et al[43]
Conversion of macrophages to immunoregulatory cells
SwineRenal artery stenosisRecovery of renal functionEirin et al[44]
Improved angiogenesis
Increased production of VEGF and bFGF
SwineRenal artery stenosisRecovery of renal functionZhu et al[45]
Improved angiogenesis
Decreased oxidative stress
SwineRenal artery stenosisRecovery of renal functionEbrahimi et al[46]
Improved angiogenesis
Increased production of VEGF
MouseRenal fibrosis (unilateral clamping of the renal pedicle)Recovery of renal functionDonizetti-Oliveira et al[47]
Reduced fibrosis
Decreased expression of IL6 and TNF-α