Copyright ©The Author(s) 2019.
World J Transplant. Aug 26, 2019; 9(4): 62-80
Published online Aug 26, 2019. doi: 10.5500/wjt.v9.i4.62
Table 5 Studies on molecular markers measured in 0-h biopsies (up to 2011)
Ref.Patsf/uFindings/timing of biopsy-technology
Hoffmann et al[28], 2002241 hIRI injury ass w increased adhesion, chemotaxis, apoptosis, monocyte recruitment/activation transcripts.Post-reperfusion/RT-PCR
Hauser et al[29],2004361Increased Communication, apoptosis, inflammation
Kainzet al[30],2004101DD kidneys distinctly different transcripts in the TI but not in the G compartment compared to LD. End of CIT/microarrays
Avihingsanon et al[31],200575615 selected genes associated with outcomes, included DGF, REJ and 6 mofunction. Post-reperfusion/RT-PCR
Kainzet al[32],20073112Increased immunity, signal transduction, oxidative stress response associated with lower 1-year function
Park et al[33],20071512Increased inflammation and immune response at 1-year in uncomplicated grafts
Mas et al[34],2008333Increased immunity, inflammation and apoptosis genes associated with DGF. End of CIT/microarrays
Mueller et al[35],20088712Increased acute phase, complement, chemochines and reduced metabolism, transporters in DD versus LD, transcriptome identifies risk for DGF better than clinical ± histological markers. Post-reperfusion/ microarrays
Perco et al[36], 20098212Increasedimmunity/defense, communication, apoptosis in damaged kidneys, CADI score + clinic explained 14%, 3 biomarkers 28% of 1-year creatinine variability. End of CIT/ microarrays
Naesens et al[37], 20092836Complement genes differ between LD and DD and are associated with early and late function. End of CIT and post-transplant/ microarrays
Bodonyi-Kovacs et al[38], 20107548Pre-selected genes associated with 2-year graft function. Post-reperfusion/ RT-PCR
Cravedi et al[39], 20104912LDvs DD differ by inflammation, donor age and ITGB2 prognostic for 1-year function. Post-reperfusion/RT-PCR