Systematic Reviews
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Dec 22, 2016; 6(4): 449-455
Published online Dec 22, 2016. doi: 10.5498/wjp.v6.i4.449
Cognitive-behavioural therapy for obsessive-compulsive disorder co-occurring with psychosis: Systematic review of evidence
Antonio Tundo, Roberta Necci
Antonio Tundo, Roberta Necci, Istituto di Psicopatologia, 00196 Rome, Italy
Author contributions: Tundo A designed the research and wrote the manuscript; Tundo A and Necci R contributed to the identification of trials, the data extraction, designed the review, interpreted the results and edited the manuscript.
Supported by “Fondazione dell’Istituto di Psicopatologia Onlus”, Rome, Italy.
Conflict-of-interest statement: All the authors declare that they have no competing interests.
Data sharing statement: This article is not a basic research or clinical research study so has not data share. No additional data are available than the articles cited in this review.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Antonio Tundo, MD, Istituto di Psicopatologia, Via Girolamo da Carpi 1, 00196 Rome, Italy.
Telephone: +39-06-3610955 Fax: +39-06-36002828
Received: July 27, 2016
Peer-review started: July 29, 2016
First decision: September 2, 2016
Revised: October 5, 2016
Accepted: November 1, 2016
Article in press: November 2, 2016
Published online: December 22, 2016
Core Tip

Core tip: Ten percent of patients with schizophrenia fulfill criteria for obsessive compulsive disorder (OCD) and in 1/3 of cases OCD onset is related to second-generation antipsychotic (SGA) treatment. Reviewed evidence indicates that cognitive-behavioral therapy for OCD in patients with psychosis is: (1) safe (does not worsen psychotic symptoms); (2) well accepted (discontinuation rate similar to that reported for patients with OCD without psychosis); (3) effective (symptom reduction similar to that reported for patients with OCD without psychosis); and (4) effective in patients with OCD induced by SGA as well as in patients with OCD not induced by SGA. These conclusions are preliminary.