Fiber-fluorescence in situ hybridization analyses as a diagnostic application for orientation of microduplications

Figure 2 Results of fluorescence in situ hybridization in metaphase and fiber-fluorescence in situ hybridization. A: Tandem duplication aligned in red-green-red-green is shown; B: Inverted duplication aligned in green-red-red-green is shown; C: Tandem duplication aligned in red-green-red-green is shown in a single DNA fiber; D: Inverted duplication aligned in red-green-green-red is shown; E: Tandem triplication with 3 repeats of red-green units. Arrows indicate the directions of the segments.