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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Cost effectiveness of intensive care in a low resource setting: A prospective cohort of medical critically ill patients  
Hajrunisa Cubro, Rabija Somun-Kapetanovic, Guillaume Thiery, Daniel Talmor, Ognjen Gajic 
World J Crit Care Med 5(2):150-164. Published online May 4, 2016. doi: 10.5492/wjccm.v5.i2.150
2
Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review  
Vasilios Koulouras, Georgios Papathanakos, Athanasios Papathanasiou, Georgios Nakos 
World J Crit Care Med 5(2):121-136. Published online May 4, 2016. doi: 10.5492/wjccm.v5.i2.121
3
Effects of intrapulmonary percussive ventilation on airway mucus clearance: A bench model  
Lorena Fernandez-Restrepo, Lauren Shaffer, Bravein Amalakuhan, Marcos I Restrepo, Jay Peters, Ruben Restrepo 
World J Crit Care Med 6(3):164-171. Published online Aug 4, 2017. doi: 10.5492/wjccm.v6.i3.164
4
Focus on peripherally inserted central catheters in critically ill patients  
Paolo Cotogni, Mauro Pittiruti 
World J Crit Care Med 3(4):80-94. Published online Nov 4, 2014. doi: 10.5492/wjccm.v3.i4.80
5
Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome  
Alpha A Fowler III, Christin Kim, Lawrence Lepler, Rajiv Malhotra, Orlando Debesa, Ramesh Natarajan, Bernard J Fisher, Aamer Syed, Christine DeWilde, Anna Priday, Vigneshwar Kasirajan 
World J Crit Care Med 6(1):85-90. Published online Feb 4, 2017. doi: 10.5492/wjccm.v6.i1.85
6
Vitamin C in the critically ill - indications and controversies  
Christoph S Nabzdyk, Edward A Bittner 
World J Crit Care Med 7(5):52-61. Published online Oct 16, 2018. doi: 10.5492/wjccm.v7.i5.52
7
Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis  
Lukas Buendgens, Alexander Koch, Frank Tacke 
World J Crit Care Med 5(1):57-64. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.57
8
Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock  
Jihad Mallat, Malcolm Lemyze, Laurent Tronchon, Benoît Vallet, Didier Thevenin 
World J Crit Care Med 5(1):47-56. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.47
9
10
Recruitment maneuvers in acute respiratory distress syndrome: The safe way is the best way  
Raquel S Santos, Pedro L Silva, Paolo Pelosi, Patricia RM Rocco 
World J Crit Care Med 4(4):278-286. Published online Nov 4, 2015. doi: 10.5492/wjccm.v4.i4.278
11
Plasma-Lyte 148: A clinical review  
Laurence Weinberg, Neil Collins, Kiara Van Mourik, Chong Tan, Rinaldo Bellomo 
World J Crit Care Med 5(4):235-250. Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.235
12
Fluid and electrolyte overload in critically ill patients: An overview  
Bruno Adler Maccagnan Pinheiro Besen, André Luiz Nunes Gobatto, Lívia Maria Garcia Melro, Alexandre Toledo Maciel, Marcelo Park 
World J Crit Care Med 4(2):116-129. Published online May 4, 2015. doi: 10.5492/wjccm.v4.i2.116
13
Severe trauma in the geriatric population  
Juan Antonio Llompart-Pou, Jon Pérez-Bárcena, Mario Chico-Fernández, Marcelino Sánchez-Casado, Joan Maria Raurich 
World J Crit Care Med 6(2):99-106. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.99
14
Steps to consider in the approach and management of critically ill patient with spontaneous intracerebral hemorrhage  
Daniel Agustin Godoy, Gustavo Rene Piñero, Patricia Koller, Luca Masotti, Mario Di Napoli 
World J Crit Care Med 4(3):213-229. Published online Aug 4, 2015. doi: 10.5492/wjccm.v4.i3.213
15
Point of care venous Doppler ultrasound: Exploring the missing piece of bedside hemodynamic assessment  
Pablo Galindo, Carlos Gasca, Eduardo R Argaiz, Abhilash Koratala 
World J Crit Care Med 10(6):310-322. Published online Nov 9, 2021. doi: 10.5492/wjccm.v10.i6.310
16
Anticoagulant modulation of inflammation in severe sepsis  
Karen S Allen, Eva Sawheny, Gary T Kinasewitz 
World J Crit Care Med 4(2):105-115. Published online May 4, 2015. doi: 10.5492/wjccm.v4.i2.105
17
Tumor lysis syndrome: A clinical review  
Aibek E Mirrakhimov, Prakruthi Voore, Maliha Khan, Alaa M Ali 
World J Crit Care Med 4(2):130-138. Published online May 4, 2015. doi: 10.5492/wjccm.v4.i2.130
18
Severe sepsis and septic shock in the elderly: An overview  
Prashant Nasa, Deven Juneja, Omender Singh 
World J Crit Care Med 1(1):23-30. Published online Feb 4, 2012. doi: 10.5492/wjccm.v1.i1.23
19
Extracorporeal membrane oxygenation for pediatric respiratory failure: History, development and current status  
Anna Maslach-Hubbard, Susan L Bratton 
World J Crit Care Med 2(4):29-39. Published online Nov 4, 2013. doi: 10.5492/wjccm.v2.i4.29
20
21
Critical care management and intensive care unit outcomes following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy  
Sumit Kapoor, Adel Bassily-Marcus, Rafael Alba Yunen, Parissa Tabrizian, Sabrine Semoin, Joseph Blankush, Daniel Labow, John Oropello, Anthony Manasia, Roopa Kohli-Seth 
World J Crit Care Med 6(2):116-123. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.116
22
Early debridement and delayed primary vascularized cover in forearm electrical burns: A prospective study  
Aniruddh Mene, Gautam Biswas, Atul Parashar, Anish Bhattacharya 
World J Crit Care Med 5(4):228-234. Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.228
23
Neuroprotective measures in children with traumatic brain injury  
Shruti Agrawal, Ricardo Garcia Branco 
World J Crit Care Med 5(1):36-46. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.36
24
Characteristics of postintensive care syndrome in survivors of pediatric critical illness: A systematic review  
Elizabeth A Herrup, Beth Wieczorek, Sapna R Kudchadkar 
World J Crit Care Med 6(2):124-134. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.124
25
Implementation of enteral feeding protocol in an intensive care unit: Before-and-after study  
Martin Padar, Gerli Uusvel, Liis Starkopf, Joel Starkopf, Annika Reintam Blaser 
World J Crit Care Med 6(1):56-64. Published online Feb 4, 2017. doi: 10.5492/wjccm.v6.i1.56
26
Controversies in fluid therapy: Type, dose and toxicity  
Robert C McDermid, Karthik Raghunathan, Adam Romanovsky, Andrew D Shaw, Sean M Bagshaw 
World J Crit Care Med 3(1):24-33. Published online Feb 4, 2014. doi: 10.5492/wjccm.v3.i1.24
27
Prognostic categorization of intensive care septic patients  
Mohamed Ezzat Moemen 
World J Crit Care Med 1(3):67-79. Published online Jun 4, 2012. doi: 10.5492/wjccm.v1.i3.67
28
29
Timing, method and discontinuation of hydrocortisone administration for septic shock patients  
Miguel A Ibarra-Estrada, Quetzalcóatl Chávez-Peña, Claudia I Reynoso-Estrella, Jorge Rios-Zermeño, Pável E Aguilera-González, Miguel A García-Soto, Guadalupe Aguirre-Avalos 
World J Crit Care Med 6(1):65-73. Published online Feb 4, 2017. doi: 10.5492/wjccm.v6.i1.65
30
Adverse events in critical care: Search and active detection through the Trigger Tool  
Francisco J Molina, Paula T Rivera, Alejandro Cardona, Diana C Restrepo, Oralia Monroy, Daniel Rodas, Juan G Barrientos 
World J Crit Care Med 7(1):9-15. Published online Feb 4, 2018. doi: 10.5492/wjccm.v7.i1.9
31
Point-of-care ultrasound for critically-ill patients: A mini-review of key diagnostic features and protocols  
Yie Hui Lau, Kay Choong See 
World J Crit Care Med 11(2):70-84. Published online Mar 9, 2022. doi: 10.5492/wjccm.v11.i2.70
32
Iatrogenic pneumothorax related to mechanical ventilation  
Chien-Wei Hsu, Shu-Fen Sun 
World J Crit Care Med 3(1):8-14. Published online Feb 4, 2014. doi: 10.5492/wjccm.v3.i1.8
33
Invasive candidiasis in critical care setting, updated recommendations from “Invasive Fungal Infections-Clinical Forum”, Iran  
Ashraf Elhoufi, Arezoo Ahmadi, Amir Mohammad Hashem Asnaashari, Mohammad Ali Davarpanah, Behrooz Farzanegan Bidgoli, Omid Moradi Moghaddam, Mohammad Torabi-Nami, Saeed Abbasi, Malak El-Sobky, Ali Ghaziani, Mohammad Hossein Jarrahzadeh, Reza Shahrami, Farzad Shirazian, Farhad Soltani, Homeira Yazdinejad, Farid Zand 
World J Crit Care Med 3(4):102-112. Published online Nov 4, 2014. doi: 10.5492/wjccm.v3.i4.102
34
Brain-lung crosstalk: Implications for neurocritical care patients  
Ségolène Mrozek, Jean-Michel Constantin, Thomas Geeraerts 
World J Crit Care Med 4(3):163-178. Published online Aug 4, 2015. doi: 10.5492/wjccm.v4.i3.163
35
Clinical decision support for drug related events: Moving towards better prevention  
Sandra L Kane-Gill, Archita Achanta, John A Kellum, Steven M Handler 
World J Crit Care Med 5(4):204-211. Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.204
36
Optimizing the value of measuring inferior vena cava diameter in shocked patients  
Fikri M Abu-Zidan 
World J Crit Care Med 5(1):7-11. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.7
37
Clinical characteristics and outcomes associated with nasal intermittent mandatory ventilation in acute pediatric respiratory failure  
Billy C Wang, Theodore Pei, Cheryl B Lin, Rong Guo, David Elashoff, James A Lin, Carol Pineda 
World J Crit Care Med 7(4):46-51. Published online Sep 7, 2018. doi: 10.5492/wjccm.v7.i4.46
38
Severe scrub typhus infection: Clinical features, diagnostic challenges and management  
John Victor Peter, Thomas I Sudarsan, John Anthony J Prakash, George M Varghese 
World J Crit Care Med 4(3):244-250. Published online Aug 4, 2015. doi: 10.5492/wjccm.v4.i3.244
39
Modeling cardiac arrest and resuscitation in the domestic pig  
Brandon H Cherry, Anh Q Nguyen, Roger A Hollrah, Albert H Olivencia-Yurvati, Robert T Mallet 
World J Crit Care Med 4(1):1-12. Published online Feb 4, 2015. doi: 10.5492/wjccm.v4.i1.1
40
Acute cor pulmonale in patients with acute respiratory distress syndrome: A comprehensive review  
Kay Choong See 
World J Crit Care Med 10(2):35-42. Published online Mar 9, 2021. doi: 10.5492/wjccm.v10.i2.35
41
Independent lung ventilation: Implementation strategies and review of literature  
Sheri Berg, Edward A Bittner, Lorenzo Berra, Robert M Kacmarek, Abraham Sonny 
World J Crit Care Med 8(4):49-58. Published online Jul 31, 2019. doi: 10.5492/wjccm.v8.i4.49
42
Effects of mineralocorticoid receptor antagonists on responses to hemorrhagic shock in rats  
Kanako Yamamoto, Takashi Yamamoto, Masayuki Takamura, Soichiro Usui, Hisayoshi Murai, Shuichi Kaneko, Takumi Taniguchi 
World J Crit Care Med 7(1):1-8. Published online Feb 4, 2018. doi: 10.5492/wjccm.v7.i1.1
43
Nutrient stimulation of mesenteric blood flow - implications for older critically ill patients  
Thu AN Nguyen, Yasmine Ali Abdelhamid, Liza K Phillips, Leeanne S Chapple, Michael Horowitz, Karen L Jones, Adam M Deane 
World J Crit Care Med 6(1):28-36. Published online Feb 4, 2017. doi: 10.5492/wjccm.v6.i1.28
44
General anesthesia mediated by effects on ion channels  
Cheng Zhou, Jin Liu, Xiang-Dong Chen 
World J Crit Care Med 1(3):80-93. Published online Jun 4, 2012. doi: 10.5492/wjccm.v1.i3.80
45
Rhabdomyolysis, compartment syndrome and thermal injury  
Yusuf Kenan Coban 
World J Crit Care Med 3(1):1-7. Published online Feb 4, 2014. doi: 10.5492/wjccm.v3.i1.1
46
Enteral nutrition administration in a surgical intensive care unit: Achieving goals with better strategies  
Sara Wilson, Nagendra Y Madisi, Adel Bassily-Marcus, Anthony Manasia, John Oropello, Roopa Kohli-Seth 
World J Crit Care Med 5(3):180-186. Published online Aug 4, 2016. doi: 10.5492/wjccm.v5.i3.180
47
Deep sternal wound infection after cardiac surgery: Evidences and controversies  
Paolo Cotogni, Cristina Barbero, Mauro Rinaldi 
World J Crit Care Med 4(4):265-273. Published online Nov 4, 2015. doi: 10.5492/wjccm.v4.i4.265
48
Respiratory failure in the hematopoietic stem cell transplant recipient  
Patrick M Wieruszewski, Svetlana Herasevich, Ognjen Gajic, Hemang Yadav 
World J Crit Care Med 7(5):62-72. Published online Oct 16, 2018. doi: 10.5492/wjccm.v7.i5.62
49
Determination of functional prognosis in hospitalized patients following an intensive care admission  
Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, George Ntoumenopoulos, Jerffesson Dias, Fernando S Guimaraes 
World J Crit Care Med 5(4):219-227. Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.219
50
Female gonadal hormone effects on microglial activation and functional outcomes in a mouse model of moderate traumatic brain injury  
Odera Umeano, Haichen Wang, Hana Dawson, Beilei Lei, Afoma Umeano, Dawn Kernagis, Michael L James 
World J Crit Care Med 6(2):107-115. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.107