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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review  
Vasilios Koulouras, Georgios Papathanakos, Athanasios Papathanasiou, Georgios Nakos 
World J Crit Care Med 5(2):121-136. Published online May 4, 2016. doi: 10.5492/wjccm.v5.i2.121
2
Focus on peripherally inserted central catheters in critically ill patients  
Paolo Cotogni, Mauro Pittiruti 
World J Crit Care Med 3(4):80-94. Published online Nov 4, 2014. doi: 10.5492/wjccm.v3.i4.80
3
Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock  
Jihad Mallat, Malcolm Lemyze, Laurent Tronchon, Benoît Vallet, Didier Thevenin 
World J Crit Care Med 5(1):47-56. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.47
4
5
Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis  
Lukas Buendgens, Alexander Koch, Frank Tacke 
World J Crit Care Med 5(1):57-64. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.57
6
Steps to consider in the approach and management of critically ill patient with spontaneous intracerebral hemorrhage  
Daniel Agustin Godoy, Gustavo Rene Piñero, Patricia Koller, Luca Masotti, Mario Di Napoli 
World J Crit Care Med 4(3):213-229. Published online Aug 4, 2015. doi: 10.5492/wjccm.v4.i3.213
7
Recruitment maneuvers in acute respiratory distress syndrome: The safe way is the best way  
Raquel S Santos, Pedro L Silva, Paolo Pelosi, Patricia RM Rocco 
World J Crit Care Med 4(4):278-286. Published online Nov 4, 2015. doi: 10.5492/wjccm.v4.i4.278
8
Fluid and electrolyte overload in critically ill patients: An overview  
Bruno Adler Maccagnan Pinheiro Besen, André Luiz Nunes Gobatto, Lívia Maria Garcia Melro, Alexandre Toledo Maciel, Marcelo Park 
World J Crit Care Med 4(2):116-129. Published online May 4, 2015. doi: 10.5492/wjccm.v4.i2.116
9
Anticoagulant modulation of inflammation in severe sepsis  
Karen S Allen, Eva Sawheny, Gary T Kinasewitz 
World J Crit Care Med 4(2):105-115. Published online May 4, 2015. doi: 10.5492/wjccm.v4.i2.105
10
Plasma-Lyte 148: A clinical review  
Laurence Weinberg, Neil Collins, Kiara Van Mourik, Chong Tan, Rinaldo Bellomo 
World J Crit Care Med 5(4):235-250. Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.235
11
Prognostic categorization of intensive care septic patients  
Mohamed Ezzat Moemen 
World J Crit Care Med 1(3):67-79. Published online Jun 4, 2012. doi: 10.5492/wjccm.v1.i3.67
12
Cost effectiveness of intensive care in a low resource setting: A prospective cohort of medical critically ill patients  
Hajrunisa Cubro, Rabija Somun-Kapetanovic, Guillaume Thiery, Daniel Talmor, Ognjen Gajic 
World J Crit Care Med 5(2):150-164. Published online May 4, 2016. doi: 10.5492/wjccm.v5.i2.150
13
Controversies in fluid therapy: Type, dose and toxicity  
Robert C McDermid, Karthik Raghunathan, Adam Romanovsky, Andrew D Shaw, Sean M Bagshaw 
World J Crit Care Med 3(1):24-33. Published online Feb 4, 2014. doi: 10.5492/wjccm.v3.i1.24
14
Extracorporeal membrane oxygenation for pediatric respiratory failure: History, development and current status  
Anna Maslach-Hubbard, Susan L Bratton 
World J Crit Care Med 2(4):29-39. Published online Nov 4, 2013. doi: 10.5492/wjccm.v2.i4.29
15
16
Invasive candidiasis in critical care setting, updated recommendations from “Invasive Fungal Infections-Clinical Forum”, Iran  
Ashraf Elhoufi, Arezoo Ahmadi, Amir Mohammad Hashem Asnaashari, Mohammad Ali Davarpanah, Behrooz Farzanegan Bidgoli, Omid Moradi Moghaddam, Mohammad Torabi-Nami, Saeed Abbasi, Malak El-Sobky, Ali Ghaziani, Mohammad Hossein Jarrahzadeh, Reza Shahrami, Farzad Shirazian, Farhad Soltani, Homeira Yazdinejad, Farid Zand 
World J Crit Care Med 3(4):102-112. Published online Nov 4, 2014. doi: 10.5492/wjccm.v3.i4.102
17
Severe trauma in the geriatric population  
Juan Antonio Llompart-Pou, Jon Pérez-Bárcena, Mario Chico-Fernández, Marcelino Sánchez-Casado, Joan Maria Raurich 
World J Crit Care Med 6(2):99-106. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.99
18
Timing, method and discontinuation of hydrocortisone administration for septic shock patients  
Miguel A Ibarra-Estrada, Quetzalcóatl Chávez-Peña, Claudia I Reynoso-Estrella, Jorge Rios-Zermeño, Pável E Aguilera-González, Miguel A García-Soto, Guadalupe Aguirre-Avalos 
World J Crit Care Med 6(1):65-73. Published online Feb 4, 2017. doi: 10.5492/wjccm.v6.i1.65
19
Severe sepsis and septic shock in the elderly: An overview  
Prashant Nasa, Deven Juneja, Omender Singh 
World J Crit Care Med 1(1):23-30. Published online Feb 4, 2012. doi: 10.5492/wjccm.v1.i1.23
20
21
Critical care management and intensive care unit outcomes following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy  
Sumit Kapoor, Adel Bassily-Marcus, Rafael Alba Yunen, Parissa Tabrizian, Sabrine Semoin, Joseph Blankush, Daniel Labow, John Oropello, Anthony Manasia, Roopa Kohli-Seth 
World J Crit Care Med 6(2):116-123. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.116
22
Modeling cardiac arrest and resuscitation in the domestic pig  
Brandon H Cherry, Anh Q Nguyen, Roger A Hollrah, Albert H Olivencia-Yurvati, Robert T Mallet 
World J Crit Care Med 4(1):1-12. Published online Feb 4, 2015. doi: 10.5492/wjccm.v4.i1.1
23
Characteristics of postintensive care syndrome in survivors of pediatric critical illness: A systematic review  
Elizabeth A Herrup, Beth Wieczorek, Sapna R Kudchadkar 
World J Crit Care Med 6(2):124-134. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.124
24
Tumor lysis syndrome: A clinical review  
Aibek E Mirrakhimov, Prakruthi Voore, Maliha Khan, Alaa M Ali 
World J Crit Care Med 4(2):130-138. Published online May 4, 2015. doi: 10.5492/wjccm.v4.i2.130
25
Early debridement and delayed primary vascularized cover in forearm electrical burns: A prospective study  
Aniruddh Mene, Gautam Biswas, Atul Parashar, Anish Bhattacharya 
World J Crit Care Med 5(4):228-234. Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.228
26
Neuroprotective measures in children with traumatic brain injury  
Shruti Agrawal, Ricardo Garcia Branco 
World J Crit Care Med 5(1):36-46. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.36
27
Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome  
Alpha A Fowler III, Christin Kim, Lawrence Lepler, Rajiv Malhotra, Orlando Debesa, Ramesh Natarajan, Bernard J Fisher, Aamer Syed, Christine DeWilde, Anna Priday, Vigneshwar Kasirajan 
World J Crit Care Med 6(1):85-90. Published online Feb 4, 2017. doi: 10.5492/wjccm.v6.i1.85
28
Clinical decision support for drug related events: Moving towards better prevention  
Sandra L Kane-Gill, Archita Achanta, John A Kellum, Steven M Handler 
World J Crit Care Med 5(4):204-211. Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.204
29
Brain-lung crosstalk: Implications for neurocritical care patients  
Ségolène Mrozek, Jean-Michel Constantin, Thomas Geeraerts 
World J Crit Care Med 4(3):163-178. Published online Aug 4, 2015. doi: 10.5492/wjccm.v4.i3.163
30
Vitamin C in the critically ill - indications and controversies  
Christoph S Nabzdyk, Edward A Bittner 
World J Crit Care Med 7(5):52-61. Published online Oct 16, 2018. doi: 10.5492/wjccm.v7.i5.52
31
Optimizing the value of measuring inferior vena cava diameter in shocked patients  
Fikri M Abu-Zidan 
World J Crit Care Med 5(1):7-11. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.7
32
Iatrogenic pneumothorax related to mechanical ventilation  
Chien-Wei Hsu, Shu-Fen Sun 
World J Crit Care Med 3(1):8-14. Published online Feb 4, 2014. doi: 10.5492/wjccm.v3.i1.8
33
Rhabdomyolysis, compartment syndrome and thermal injury  
Yusuf Kenan Coban 
World J Crit Care Med 3(1):1-7. Published online Feb 4, 2014. doi: 10.5492/wjccm.v3.i1.1
34
Respiratory mechanics in brain injury: A review  
Antonia Koutsoukou, Maria Katsiari, Stylianos E Orfanos, Anastasia Kotanidou, Maria Daganou, Magdalini Kyriakopoulou, Nikolaos G Koulouris, Nikoletta Rovina 
World J Crit Care Med 5(1):65-73. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.65
35
Preemptive mechanical ventilation can block progressive acute lung injury  
Benjamin Sadowitz, Sumeet Jain, Michaela Kollisch-Singule, Joshua Satalin, Penny Andrews, Nader Habashi, Louis A Gatto, Gary Nieman 
World J Crit Care Med 5(1):74-82. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.74
36
Deep sternal wound infection after cardiac surgery: Evidences and controversies  
Paolo Cotogni, Cristina Barbero, Mauro Rinaldi 
World J Crit Care Med 4(4):265-273. Published online Nov 4, 2015. doi: 10.5492/wjccm.v4.i4.265
37
General anesthesia mediated by effects on ion channels  
Cheng Zhou, Jin Liu, Xiang-Dong Chen 
World J Crit Care Med 1(3):80-93. Published online Jun 4, 2012. doi: 10.5492/wjccm.v1.i3.80
38
Implementation of enteral feeding protocol in an intensive care unit: Before-and-after study  
Martin Padar, Gerli Uusvel, Liis Starkopf, Joel Starkopf, Annika Reintam Blaser 
World J Crit Care Med 6(1):56-64. Published online Feb 4, 2017. doi: 10.5492/wjccm.v6.i1.56
39
Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients  
Elisabeth Paramythiotou, Christina Routsi 
World J Crit Care Med 5(2):111-120. Published online May 4, 2016. doi: 10.5492/wjccm.v5.i2.111
40
Severe scrub typhus infection: Clinical features, diagnostic challenges and management  
John Victor Peter, Thomas I Sudarsan, John Anthony J Prakash, George M Varghese 
World J Crit Care Med 4(3):244-250. Published online Aug 4, 2015. doi: 10.5492/wjccm.v4.i3.244
41
Enteral nutrition administration in a surgical intensive care unit: Achieving goals with better strategies  
Sara Wilson, Nagendra Y Madisi, Adel Bassily-Marcus, Anthony Manasia, John Oropello, Roopa Kohli-Seth 
World J Crit Care Med 5(3):180-186. Published online Aug 4, 2016. doi: 10.5492/wjccm.v5.i3.180
42
Female gonadal hormone effects on microglial activation and functional outcomes in a mouse model of moderate traumatic brain injury  
Odera Umeano, Haichen Wang, Hana Dawson, Beilei Lei, Afoma Umeano, Dawn Kernagis, Michael L James 
World J Crit Care Med 6(2):107-115. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.107
43
Nutrient stimulation of mesenteric blood flow - implications for older critically ill patients  
Thu AN Nguyen, Yasmine Ali Abdelhamid, Liza K Phillips, Leeanne S Chapple, Michael Horowitz, Karen L Jones, Adam M Deane 
World J Crit Care Med 6(1):28-36. Published online Feb 4, 2017. doi: 10.5492/wjccm.v6.i1.28
44
Hemolytic uremic syndrome in adults: A case report  
Fabiel Gerardo Pérez-Cruz, Patricia Villa-Díaz, María Consuelo Pintado-Delgado, María Loreto Fernández_Rodríguez, Ana Blasco-Martínez, María Pérez-Fernández 
World J Crit Care Med 6(2):135-139. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.135
45
Corticosteroids for severe influenza pneumonia: A critical appraisal  
Wagner Luis Nedel, David Garcia Nora, Jorge Ibrain Figueira Salluh, Thiago Lisboa, Pedro Póvoa 
World J Crit Care Med 5(1):89-95. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.89
46
47
Determination of functional prognosis in hospitalized patients following an intensive care admission  
Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, George Ntoumenopoulos, Jerffesson Dias, Fernando S Guimaraes 
World J Crit Care Med 5(4):219-227. Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.219
48
Treatment and prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy  
Hiroshi Yasuda, Yasumasa Matsuo, Yoshinori Sato, Sun-ichiro Ozawa, Shinya Ishigooka, Masaki Yamashita, Hiroyuki Yamamoto, Fumio Itoh 
World J Crit Care Med 4(1):40-46. Published online Feb 4, 2015. doi: 10.5492/wjccm.v4.i1.40
49
In vivo analysis of intestinal permeability following hemorrhagic shock  
Tom Alsaigh, Marisol Chang, Michael Richter, Rafi Mazor, Erik B Kistler 
World J Crit Care Med 4(4):287-295. Published online Nov 4, 2015. doi: 10.5492/wjccm.v4.i4.287
50
Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function  
Emer P Reeves, Cormac McCarthy, Oliver J McElvaney, Maya Sakthi N Vijayan, Michelle M White, Danielle M Dunlea, Kerstin Pohl, Noreen Lacey, Noel G McElvaney 
World J Crit Care Med 4(3):179-191. Published online Aug 4, 2015. doi: 10.5492/wjccm.v4.i3.179