Dendritic cells and the extracellular matrix: A challenge for maintaining tolerance/homeostasis

Figure 2 Mature skin dendritic cells egress via lymphatics that display secondary lymphoid tissue chemokine (SLC/CCL21) constitutively. Shown here are two mature DC expressing MHC class II (green) located within a lymphatic vessel that presents SLC (red). Reprinted from Jakob T, Ring J, Udey MC. Multistep navigation of Langerhans/dendritic cells in and out of the skin. J Allergy Clin Immunol 2001; 108: 688-696 Copyright (2001), with permission from Elsevier. Courtesy of Saeki H and Hwang S, National Cancer Institute, Bethesda, MD.