Copyright ©The Author(s) 2019.
World J Stomatol. Jan 15, 2019; 7(1): 1-19
Published online Jan 15, 2019. doi: 10.5321/wjs.v7.i1.1
Table 2 Studies retrieved from PubMed database evaluating the effect of DPSCs on nerve repair or regeneration in-vivo
AuthorPublication yearSource of stem cellsTarget nervesStudy modelObjectiveOutcome
Ullah et al[82], 20172017Human DPSCs; Differentiated neuronal cells from DPSCs5-mm gap sciatic nerve transectionAnimal rat modelTo evaluate the in-vivo peripheral nerve regeneration potential of human DPSCs and differentiated neuronal cells from DPSCs.In-vivo transplantation of the undifferentiated hDPSCs could exhibit sufficient and excellent peripheral nerve regeneration potential.
Spyridopoulos et al[83], 20152015DPSCs isolated from second lateral incisor pigsTransected fifth and sixth intercostal nervesAnimal pig modelExamined the potential of DPSCs for peripheral nerve regeneration, using biodegradable collagen conduits.The nerves where DPSCs were injected exhibited morphological and functional recovery.