Copyright ©The Author(s) 2015.
World J Hematol. Aug 6, 2015; 4(3): 16-53
Published online Aug 6, 2015. doi: 10.5315/wjh.v4.i3.16
Figure 8
Figure 8 Hypercellular false and normocellular true essential thrombocythemia. A and B: Hypercellular false ET or prefibrotic PMF according to Thiele (Table 6) consistent with CMGM according to Georgii et al[35] (1990), or primary megakaryocytic granulocytic myeloproliferation (PMGM122) featured by dense clustered immature megakaryopoiesis and the predominance of immature cloud-like nuclei (Kvasnicka), which are not seen in JAK2V617F positive ET and PV; C and D: Normocellular True ET (World Health Organization-ET, Table 5) according to Thiele and Michiels 1988-2006[59,62,107] with the presence of large to giant megakaryocytes larger than in JAK2V617F positive ET and PV. True ET as defined by Thiele seems to our experience most consistent with normocellular JAK2 wild type ET carrying the MPL515 mutation featured by clustered large and giant megakaryocytes in a normocellular bone marrow, which usually runs a very benign course. ET: Essential thrombocythemia; PV: Polycythemia vera; CMGM: Chronic megakaryocytic granulocytic myeloproliferation.