Editorial
Copyright ©2013 Baishideng Publishing Group Co.
World J Hematol. Nov 6, 2013; 2(4): 99-108
Published online Nov 6, 2013. doi: 10.5315/wjh.v2.i4.99
Table 6 The 2006 Antwerp Classification of recessive von Willebrand disease type 3, recessive severe on Willebrand disease type 1 and obligatory carriers of a null or missense allele with asymptomatic or mild on Willebrand disease type 1 and variable penetrance of bleeding tendency
Category VWDBTFVIII: C (%)VWF (%) AgRCoRIPABleeding typeVWF gene mutation
Severe type 3↑↑↑1-9zerozerozeroSevereDouble
RecessiveHemophiliaNonsense
Severe type 1↑↑↑9-401-100-6zeroModerateDouble
Recessive VWDSevereMissense
Blood group O (30-32)N35-15035-15035-150NAsympNone
(Pseude-VWD)Very mild
Carrier type 3N↑30-14015-9015-90NAsympSingle
Minor influence (-10%)Very mildNon-sense
of bloodgroup O(null allele)
Carrier type 1NNNNNAsympSingle
(polymorphism)Missense
Mild type 1N↑20-8020-5020-50NMildMis/Non-sense
Recessive oror Y1584C/
variable penetrance and multigenetic backgroudBloodgroup O[19
Dominant type 1N↑20-8010-400-30NMildSingle
Secretion defect↑/↑↑5-205-205-20ModerateMissense
Dominant type 1
VicenzaN/↑< 15< 15< 15ModerateSingleR120SH
Missense