Copyright ©The Author(s) 2019.
World J Clin Oncol. Jan 10, 2019; 10(1): 1-13
Published online Jan 10, 2019. doi: 10.5306/wjco.v10.i1.1
Table 6 Other
AuthorType of studySample sizeInterventionXerostomia symptomsSalivary functionQuality of lifeToxicity
Wong et al[54], 2015Phase III randomized controlled trial148ALTENS vs oral PC (5 mg TID for 12 wk)NABasal WSP and stimulated WSP: no sig differenceXeQOLs: no difference at 15 mo. 83% ALTENS positive responders vs 62.8% PC, SS at 15 mo.2 G3 events in PC (dry mouth, blurry vision) vs 1 G3 event in ALTENS (headache). 61.6% of PC had Grade 3 or less non-hematologic AEs vs 20.9% of ALTENS
Teguh et al[52], 2009randomized controlled trial19Hyperbaric O2 (30 sessions at 2.5 ATA with O2 breathing for 90 min daily, 5 d a week) vs controlVisual analogue scale dry mo better on O2 (SS)NAEORTC QLQ-C30 and H and N35; Sticky saliva better on O2 (SS) and less dry mouth on O2 (SS)NA
Blom et al[53], 1996randomized placebo-controlled trial38acupuncture vs placebo (superficial acupuncture)NAsalivary flow rate: no dif. between groups; both groups showed increased flow rates after treatmentNo specific endpointsTiredness, small haematomas at acupuncture sites