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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Starring role of toll-like receptor-4 activation in the gut-liver axis  
Simone Carotti, Michele Pier Luca Guarino, Umberto Vespasiani-Gentilucci, Sergio Morini 
World J Gastrointest Pathophysiol 6(4):99-109. Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.99
2
Celiac disease: From pathophysiology to treatment  
Ilaria Parzanese, Dorina Qehajaj, Federica Patrinicola, Merica Aralica, Maurizio Chiriva-Internati, Sanja Stifter, Luca Elli, Fabio Grizzi 
World J Gastrointest Pathophysiol 8(2):27-38. Published online May 15, 2017. doi: 10.4291/wjgp.v8.i2.27
3
Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers  
Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, Kimberly M Carbajal 
World J Gastrointest Pathophysiol 8(3):117-126. Published online Aug 15, 2017. doi: 10.4291/wjgp.v8.i3.117
4
Diagnosis of gastrointestinal bleeding: A practical guide for clinicians  
Bong Sik Matthew Kim, Bob T Li, Alexander Engel, Jaswinder S Samra, Stephen Clarke, Ian D Norton, Angela E Li 
World J Gastrointest Pathophysiol 5(4):467-478. Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.467
5
Esophageal testing: What we have so far  
Nicola de Bortoli, Irene Martinucci, Lorenzo Bertani, Salvatore Russo, Riccardo Franchi, Manuele Furnari, Salvatore Tolone, Giorgia Bodini, Valeria Bolognesi, Massimo Bellini, Vincenzo Savarino, Santino Marchi, Edoardo Vincenzo Savarino 
World J Gastrointest Pathophysiol 7(1):72-85. Published online Feb 15, 2016. doi: 10.4291/wjgp.v7.i1.72
6
Contemporary surgical management of rectovaginal fistula in Crohn's disease  
Michael A Valente, Tracy L Hull 
World J Gastrointest Pathophysiol 5(4):487-495. Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.487
7
Contemporary review of drug-induced pancreatitis: A different perspective  
Whitney Y Hung, Odaliz Abreu Lanfranco 
World J Gastrointest Pathophysiol 5(4):405-415. Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.405
8
Role of Helicobacter pylori infection in pathogenesis of gastric carcinoma  
Rong-Guang Zhang, Guang-Cai Duan, Qing-Tang Fan, Shuai-Yin Chen 
World J Gastrointest Pathophysiol 7(1):97-107. Published online Feb 15, 2016. doi: 10.4291/wjgp.v7.i1.97
9
Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology  
Linda Chia-Hui Yu, Jin-Town Wang, Shu-Chen Wei, Yen-Hsuan Ni 
World J Gastrointest Pathophysiol 3(1):27-43. Published online Feb 15, 2012. doi: 10.4291/wjgp.v3.i1.27
10
Acute pancreatitis in children and adolescents  
Mitsuyoshi Suzuki, Jin Kan Sai, Toshiaki Shimizu 
World J Gastrointest Pathophysiol 5(4):416-426. Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.416
11
Promising biological therapies for ulcerative colitis: A review of the literature  
Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino 
World J Gastrointest Pathophysiol 6(4):219-227. Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.219
12
Intestinal barrier: A gentlemen’s agreement between microbiota and immunity  
Andrea Moro Caricilli, Angela Castoldi, Niels Olsen Saraiva Câmara 
World J Gastrointest Pathophysiol 5(1):18-32. Published online Feb 15, 2014. doi: 10.4291/wjgp.v5.i1.18
13
Paneth cells in intestinal physiology and pathophysiology  
Nikolaus Gassler 
World J Gastrointest Pathophysiol 8(4):150-160. Published online Nov 15, 2017. doi: 10.4291/wjgp.v8.i4.150
14
Insulin resistance in development and progression of nonalcoholic fatty liver disease  
Shahinul Alam, Golam Mustafa, Mahabubul Alam, Nooruddin Ahmad 
World J Gastrointest Pathophysiol 7(2):211-217. Published online May 15, 2016. doi: 10.4291/wjgp.v7.i2.211
15
Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice  
Mandy Heritage, Lesley Jaskowski, Kim Bridle, Catherine Campbell, David Briskey, Laurence Britton, Linda Fletcher, Luis Vitetta, V Nathan Subramaniam, Darrell Crawford 
World J Gastrointest Pathophysiol 8(2):67-76. Published online May 15, 2017. doi: 10.4291/wjgp.v8.i2.67
16
Iron deficiency anemia in inflammatory bowel disease  
Sindhu Kaitha, Muhammad Bashir, Tauseef Ali 
World J Gastrointest Pathophysiol 6(3):62-72. Published online Aug 15, 2015. doi: 10.4291/wjgp.v6.i3.62
17
Helicobacter pylori and neurological diseases: Married by the laws of inflammation  
Lourdes Álvarez-Arellano, Carmen Maldonado-Bernal 
World J Gastrointest Pathophysiol 5(4):400-404. Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.400
18
Zinc and gastrointestinal disease  
Sonja Skrovanek, Katherine DiGuilio, Robert Bailey, William Huntington, Ryan Urbas, Barani Mayilvaganan, Giancarlo Mercogliano, James M Mullin 
World J Gastrointest Pathophysiol 5(4):496-513. Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.496
19
Intestinal barrier: Molecular pathways and modifiers  
Min Kyung Jeon, Christina Klaus, Elke Kaemmerer, Nikolaus Gassler 
World J Gastrointest Pathophysiol 4(4):94-99. Published online Nov 15, 2013. doi: 10.4291/wjgp.v4.i4.94
20
21
Intra-abdominal pressure: Time ripe to revise management guidelines of acute pancreatitis?  
Jiten Jaipuria, Vimal Bhandari, Avneet Singh Chawla, Mohit Singh 
World J Gastrointest Pathophysiol 7(1):186-198. Published online Feb 15, 2016. doi: 10.4291/wjgp.v7.i1.186
22
Current application of proteomics in biomarker discovery for inflammatory bowel disease  
Patrick PY Chan, Valerie C Wasinger, Rupert W Leong 
World J Gastrointest Pathophysiol 7(1):27-37. Published online Feb 15, 2016. doi: 10.4291/wjgp.v7.i1.27
23
Polyp detection rate and pathological features in patients undergoing a comprehensive colonoscopy screening  
Hamid Asadzadeh Aghdaei, Ehsan Nazemalhosseini Mojarad, Sara Ashtari, Mohmad Amin Pourhoseingholi, Vahid Chaleshi, Fakhrosadat Anaraki, Mehrdad Haghazali, Mohammad Reza Zali 
World J Gastrointest Pathophysiol 8(1):3-10. Published online Feb 15, 2017. doi: 10.4291/wjgp.v8.i1.3
24
Mesenteric ischemia: Pathogenesis and challenging diagnostic and therapeutic modalities  
Aikaterini Mastoraki, Sotiria Mastoraki, Evgenia Tziava, Stavroula Touloumi, Nikolaos Krinos, Nikolaos Danias, Andreas Lazaris, Nikolaos Arkadopoulos 
World J Gastrointest Pathophysiol 7(1):125-130. Published online Feb 15, 2016. doi: 10.4291/wjgp.v7.i1.125
25
Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis  
Linda Hammerich, Frank Tacke 
World J Gastrointest Pathophysiol 6(3):43-50. Published online Aug 15, 2015. doi: 10.4291/wjgp.v6.i3.43
26
Endoscopic therapy for biliary strictures complicating living donor liver transplantation: Factors predicting better outcome  
Harshavardhan B Rao, Hasim Ahamed, Suprabha Panicker, Surendran Sudhindran, Rama P Venu 
World J Gastrointest Pathophysiol 8(2):77-86. Published online May 15, 2017. doi: 10.4291/wjgp.v8.i2.77
27
Mucosal healing in inflammatory bowel disease: Maintain or de-escalate therapy  
Marcello Cintolo, Giuseppe Costantino, Socrate Pallio, Walter Fries 
World J Gastrointest Pathophysiol 7(1):1-16. Published online Feb 15, 2016. doi: 10.4291/wjgp.v7.i1.1
28
Eosinophilic esophagitis: From pathophysiology to treatment  
Alessandra D’Alessandro, Dario Esposito, Marcella Pesce, Rosario Cuomo, Giovanni Domenico De Palma, Giovanni Sarnelli 
World J Gastrointest Pathophysiol 6(4):150-158. Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.150
29
Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review  
Eckhard Klieser, Stefan Swierczynski, Christian Mayr, Tarkan Jäger, Johanna Schmidt, Daniel Neureiter, Tobias Kiesslich, Romana Illig 
World J Gastrointest Pathophysiol 7(2):199-210. Published online May 15, 2016. doi: 10.4291/wjgp.v7.i2.199
30
Upper gastrointestinal bleeding risk scores: Who, when and why?  
Sara Monteiro, Tiago Cúrdia Gonçalves, Joana Magalhães, José Cotter 
World J Gastrointest Pathophysiol 7(1):86-96. Published online Feb 15, 2016. doi: 10.4291/wjgp.v7.i1.86
31
Current therapy of pediatric Crohn’s disease  
Avishay Lahad, Batia Weiss 
World J Gastrointest Pathophysiol 6(2):33-42. Published online May 15, 2015. doi: 10.4291/wjgp.v6.i2.33
32
Pancreatitis-imaging approach  
Kiran K Busireddy, Mamdoh AlObaidy, Miguel Ramalho, Janaka Kalubowila, Liu Baodong, Ilaria Santagostino, Richard C Semelka 
World J Gastrointest Pathophysiol 5(3):252-270. Published online Aug 15, 2014. doi: 10.4291/wjgp.v5.i3.252
33
Immunobiology of hepatocarcinogenesis: Ways to go or almost there?  
Pavan Patel, Steven E Schutzer, Nikolaos Pyrsopoulos 
World J Gastrointest Pathophysiol 7(3):242-255. Published online Aug 15, 2016. doi: 10.4291/wjgp.v7.i3.242
34
Nonalcoholic fatty liver disease: Diagnostic biomarkers  
Fatemeh Hadizadeh, Elham Faghihimani, Peyman Adibi 
World J Gastrointest Pathophysiol 8(2):11-26. Published online May 15, 2017. doi: 10.4291/wjgp.v8.i2.11
35
Rabeprazole is effective for bile reflux oesophagitis after total gastrectomy in a rat model  
Naoki Hashimoto 
World J Gastrointest Pathophysiol 6(1):23-28. Published online Feb 15, 2015. doi: 10.4291/wjgp.v6.i1.23
36
Hepatitis C infection and renal cell carcinoma: A systematic review and meta-analysis  
Karn Wijarnpreecha, Pitchaphon Nissaisorakarn, Suthanya Sornprom, Charat Thongprayoon, Natanong Thamcharoen, Kunlatida Maneenil, Alexander J Podboy, Wisit Cheungpasitporn 
World J Gastrointest Pathophysiol 7(4):314-319. Published online Nov 15, 2016. doi: 10.4291/wjgp.v7.i4.314
37
Laboratory markers in ulcerative colitis: Current insights and future advances  
Michele Cioffi, Antonella De Rosa, Rosalba Serao, Ilaria Picone, Maria Teresa Vietri 
World J Gastrointest Pathophysiol 6(1):13-22. Published online Feb 15, 2015. doi: 10.4291/wjgp.v6.i1.13
38
Treatment of Helicobacter pylori infection: Past, present and future  
Vasilios Papastergiou, Sotirios D Georgopoulos, Stylianos Karatapanis 
World J Gastrointest Pathophysiol 5(4):392-399. Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.392
39
Gastrointestinal dysbiosis and the use of fecal microbial transplantation in Clostridium difficile infection  
L Patrick Schenck, Paul L Beck, Justin A MacDonald 
World J Gastrointest Pathophysiol 6(4):169-180. Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.169
40
Novel biomarkers of fibrosis in Crohn’s disease  
Gianluca Pellino, Pierlorenzo Pallante, Francesco Selvaggi 
World J Gastrointest Pathophysiol 7(3):266-275. Published online Aug 15, 2016. doi: 10.4291/wjgp.v7.i3.266
41
Alcoholic hepatitis: The pivotal role of Kupffer cells  
Duminda B Suraweera, Ashley N Weeratunga, Robert W Hu, Stephen J Pandol, Richard Hu 
World J Gastrointest Pathophysiol 6(4):90-98. Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.90
42
Hypoallergenic formula with Lactobacillus rhamnosus GG for babies with colic: A pilot study of recruitment, retention, and fecal biomarkers  
Nicole Y Fatheree, Yuying Liu, Michael Ferris, Melissa Van Arsdall, Valarie McMurtry, Marcela Zozaya, Chunyan Cai, Mohammad H Rahbar, Manouchehr Hessabi, Ta Vu, Christine Wong, Juleen Min, Dat Q Tran, Fernando Navarro, Wallace Gleason, Sara Gonzalez, J Marc Rhoads 
World J Gastrointest Pathophysiol 7(1):160-170. Published online Feb 15, 2016. doi: 10.4291/wjgp.v7.i1.160
43
Pathogenesis of Crohn’s disease: Bug or no bug  
Marta Maia Bosca-Watts, Joan Tosca, Rosario Anton, Maria Mora, Miguel Minguez, Francisco Mora 
World J Gastrointest Pathophysiol 6(1):1-12. Published online Feb 15, 2015. doi: 10.4291/wjgp.v6.i1.1
44
New-found link between microbiota and obesity  
Chandra Kanti Chakraborti 
World J Gastrointest Pathophysiol 6(4):110-119. Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.110
45
Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders  
Hirotada Akiho, Eikichi Ihara, Yasuaki Motomura, Kazuhiko Nakamura 
World J Gastrointest Pathophysiol 2(5):72-81. Published online Oct 15, 2011. doi: 10.4291/wjgp.v2.i5.72
46
Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution  
Asseel Khalaf, Caroline L Hoad, Robin C Spiller, Penny A Gowland, Gordon W Moran, Luca Marciani 
World J Gastrointest Pathophysiol 6(4):140-149. Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.140
47
Alcoholic pancreatitis: New insights into the pathogenesis and treatment  
Dahn L Clemens, Katrina J Schneider, Christopher K Arkfeld, Jaclyn R Grode, Mark A Wells, Shailender Singh 
World J Gastrointest Pathophysiol 7(1):48-58. Published online Feb 15, 2016. doi: 10.4291/wjgp.v7.i1.48
48
Pancreatic cancer diagnosis by free and exosomal miRNA  
Margot Zöller 
World J Gastrointest Pathophysiol 4(4):74-90. Published online Nov 15, 2013. doi: 10.4291/wjgp.v4.i4.74
49
Sieving characteristics of cytokine- and peroxide-induced epithelial barrier leak: Inhibition by berberine  
Katherine M DiGuilio, Christina M Mercogliano, Jillian Born, Brendan Ferraro, Julie To, Brittany Mixson, Allison Smith, Mary Carmen Valenzano, James M Mullin 
World J Gastrointest Pathophysiol 7(2):223-234. Published online May 15, 2016. doi: 10.4291/wjgp.v7.i2.223
50
Microscopic colitis in patients with mild duodenal damage: A new clinical and pathological entity (“lymphocytic enterocolitis”)?  
Gabriele Antonio Bonagura, Davide Giuseppe Ribaldone, Sharmila Fagoonee, Nicoletta Sapone, Gian Paolo Caviglia, Giorgio Maria Saracco, Marco Astegiano, Rinaldo Pellicano 
World J Gastrointest Pathophysiol 7(4):307-313. Published online Nov 15, 2016. doi: 10.4291/wjgp.v7.i4.307