Copyright ©The Author(s) 2015.
World J Gastrointest Pathophysiol. Aug 15, 2015; 6(3): 43-50
Published online Aug 15, 2015. doi: 10.4291/wjgp.v6.i3.43
Table 1 Functional role of myeloid derived suppressor cells in the regulation of human and murine liver diseases
SpeciesType of diseaseSurface phenotypeFunction of MDSCMechanismRef.
HumanChronic HCV infectionCD11b+ HLA-DRlo CD33+ CD14+Inhibition of T cell proliferation and IFNγ productionArginase1[6]
HumanHCV-infected hepatocytesCD11b+/lo HLA-DRlo/- CD33+ CD14+Inhibition of T cell cytokine productionROS Cell-cell-contact[7]
HumanHCCCD11b+ HLA-DR- CD33+ CD14-Long-lasting inhibition of effector T cells[22-30]
HumanHCCHLA-DRlo/- CD14+Inhibition of natural killer cellsCell-cell-contact NKp30[33]
HumanHCCHLA-DRlo/- CD14+Induction of Treg and inhibition of effector T cellsArginase[29]
MouseCCl4-mediated fibrosisCD11b+Ly6G-Ly6ChiF4/80+Amelioration of fibrosis through inhibition of HSCIL-10 production[13]
MouseTh1-mediated inflammationCD11b+Ly6G-Ly6ChiInhibition of T cell proliferation (CD4+ and CD8+)iNOS cell-cell-contact[48]
MouseSepsisCD11b+Gr1+Inhibition of IL-12 and induction of IL-10 release by macrophagesCell-cell-contact[2]
MouseImmune-mediated hepatitisCD11b+Ly6GloLy6ChiSuppression of CD4+ T cell proliferationiNOS[46,47]
MouseConA-mediated hepatitisCD11b+Ly6G-Ly6C+Protection against liver injury through inhibition of T cellsArginase[4]
MouseConA/LPS-mediated hepatitisCD11b+Ly6GloLy6ChiSuppression of CD4+ T cell proliferation and cytokine productioniNOS cell-cell-contact[3,45]
MouseCTL-mediated liver injuryCD11b+Gr1+Suppression of CTL proliferation and IFNγ production[21]
MouseHBV (transgenics)CD11b+Gr1+Suppression of HBV-specific CTLArginase iNOS[5]
MouseHCC/primary liver tumorsCD11b+Gr1+Suppression of anti-tumor CTL[35,36,38]
MouseGastrointestinal cancer with liver metastasisCD11b+Gr1+/intInhibition of T cell proliferation and tumor cell lysis[40]