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For: Roth RA, Ganey PE. Animal models of idiosyncratic drug-induced liver injury—Current status. Critical Reviews in Toxicology 2011;41:723-39. [DOI: 10.3109/10408444.2011.575765] [Cited by in Crossref: 51] [Cited by in F6Publishing: 46] [Article Influence: 4.6] [Reference Citation Analysis]
Number Citing Articles
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3 Ogese MO, Faulkner L, Jenkins RE, French NS, Copple IM, Antoine DJ, Elmasry M, Malik H, Goldring CE, Park BK, Betts CJ, Naisbitt DJ. Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells. Toxicological Sciences 2017;158:76-89. [DOI: 10.1093/toxsci/kfx069] [Cited by in Crossref: 21] [Cited by in F6Publishing: 18] [Article Influence: 4.2] [Reference Citation Analysis]
4 Wolenski FS, Dragan YP. Understanding drug-cytokine synergistic toxicity. Cell Death Dis 2015;6:e1988. [PMID: 26583328 DOI: 10.1038/cddis.2015.321] [Reference Citation Analysis]
5 Krueger W, Boelsterli UA, Rasmussen TP. Stem Cell Strategies to Evaluate Idiosyncratic Drug-induced Liver Injury. J Clin Transl Hepatol. 2014;2:143-152. [PMID: 26355943 DOI: 10.14218/jcth.2014.00012] [Cited by in Crossref: 1] [Cited by in F6Publishing: 2] [Article Influence: 0.1] [Reference Citation Analysis]
6 Maiuri AR, Wassink B, Turkus JD, Breier AB, Lansdell T, Kaur G, Hession SL, Ganey PE, Roth RA. Synergistic Cytotoxicity from Drugs and Cytokines In Vitro as an Approach to Classify Drugs According to Their Potential to Cause Idiosyncratic Hepatotoxicity: A Proof-of-Concept Study. J Pharmacol Exp Ther 2017;362:459-73. [PMID: 28687704 DOI: 10.1124/jpet.117.242354] [Cited by in Crossref: 9] [Cited by in F6Publishing: 7] [Article Influence: 1.8] [Reference Citation Analysis]
7 Gan J, Zhang H, Humphreys WG. Drug–Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization. Chem Res Toxicol 2016;29:2040-57. [DOI: 10.1021/acs.chemrestox.6b00274] [Cited by in Crossref: 23] [Cited by in F6Publishing: 16] [Article Influence: 3.8] [Reference Citation Analysis]
8 Kuna L, Bozic I, Kizivat T, Bojanic K, Mrso M, Kralj E, Smolic R, Wu GY, Smolic M. Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives. Curr Drug Metab 2018;19:830-8. [PMID: 29788883 DOI: 10.2174/1389200219666180523095355] [Cited by in Crossref: 35] [Cited by in F6Publishing: 30] [Article Influence: 8.8] [Reference Citation Analysis]
9 Kenna JG, Thompson RA. INTEGRATED REACTIVE METABOLITE STRATEGIES. In: Iverson SL, Smith DA, editors. Metabolite Safety in Drug Development. Hoboken: John Wiley & Sons, Inc.; 2016. pp. 111-39. [DOI: 10.1002/9781118949689.ch5] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.2] [Reference Citation Analysis]
10 Raschi E, De Ponti F. Strategies for Early Prediction and Timely Recognition of Drug-Induced Liver Injury: The Case of Cyclin-Dependent Kinase 4/6 Inhibitors. Front Pharmacol 2019;10:1235. [PMID: 31708776 DOI: 10.3389/fphar.2019.01235] [Cited by in Crossref: 12] [Cited by in F6Publishing: 7] [Article Influence: 4.0] [Reference Citation Analysis]
11 Heidari R, Ahmadi F, Rahimi HR, Azarpira N, Hosseinzadeh M, Najibi A, Niknahad H. Exacerbated liver injury of antithyroid drugs in endotoxin-treated mice. Drug Chem Toxicol 2019;42:615-23. [PMID: 29722569 DOI: 10.1080/01480545.2018.1459668] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 0.8] [Reference Citation Analysis]
12 Guo Q, Yang W, Xiao B, Zhang H, Lei X, Ou H, Qin R, Jin R. Study on early biomarkers of zebrafish liver injury induced by acetaminophen. Toxin Reviews 2014;34:28-36. [DOI: 10.3109/15569543.2014.986282] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 0.4] [Reference Citation Analysis]
13 Lin Y, Xiao R, Xia BH, Zhang ZM, Li C, Wu P, Liao DF, Lin LM. Investigation of the idiosyncratic hepatotoxicity of Polygonum multiflorum Thunb. through metabolomics using GC-MS. BMC Complement Med Ther 2021;21:120. [PMID: 33845816 DOI: 10.1186/s12906-021-03276-4] [Reference Citation Analysis]
14 Gao Y, Wang Z, Tang J, Liu X, Shi W, Qin N, Wang X, Pang Y, Li R, Zhang Y, Wang J, Niu M, Bai Z, Xiao X. New incompatible pair of TCM: Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions. Front Med 2020;14:68-80. [PMID: 30924023 DOI: 10.1007/s11684-019-0690-z] [Cited by in Crossref: 10] [Cited by in F6Publishing: 11] [Article Influence: 3.3] [Reference Citation Analysis]
15 Tu C, He Q, Li CY, Niu M, Han ZX, Ge FL, Zhou YY, Zhang L, Wang XH, Zhu JX, Li RS, Song HB, Xiao XH, Wang JB. Susceptibility-Related Factor and Biomarkers of Dietary Supplement Polygonum multiflorum-Induced Liver Injury in Rats. Front Pharmacol 2019;10:335. [PMID: 31024306 DOI: 10.3389/fphar.2019.00335] [Cited by in Crossref: 13] [Cited by in F6Publishing: 10] [Article Influence: 4.3] [Reference Citation Analysis]
16 Chen M, Bisgin H, Tong L, Hong H, Fang H, Borlak J, Tong W. Toward predictive models for drug-induced liver injury in humans: are we there yet? Biomark Med. 2014;8:201-213. [PMID: 24521015 DOI: 10.2217/bmm.13.146] [Cited by in Crossref: 93] [Cited by in F6Publishing: 80] [Article Influence: 11.6] [Reference Citation Analysis]
17 Musther H, Harwood MD, Yang J, Turner DB, Rostami-Hodjegan A, Jamei M. The Constraints, Construction, and Verification of a Strain-Specific Physiologically Based Pharmacokinetic Rat Model. J Pharm Sci 2017;106:2826-38. [PMID: 28495566 DOI: 10.1016/j.xphs.2017.05.003] [Cited by in Crossref: 4] [Cited by in F6Publishing: 3] [Article Influence: 0.8] [Reference Citation Analysis]
18 van Swelm RP, Laarakkers CM, Pertijs JC, Verweij V, Masereeuw R, Russel FG. Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice. Toxicology and Applied Pharmacology 2013;269:141-9. [DOI: 10.1016/j.taap.2013.03.005] [Cited by in Crossref: 7] [Cited by in F6Publishing: 7] [Article Influence: 0.8] [Reference Citation Analysis]
19 Zhang X, Li C, Gong Z. Development of a convenient in vivo hepatotoxin assay using a transgenic zebrafish line with liver-specific DsRed expression. PLoS One 2014;9:e91874. [PMID: 24626481 DOI: 10.1371/journal.pone.0091874] [Cited by in Crossref: 31] [Cited by in F6Publishing: 25] [Article Influence: 3.9] [Reference Citation Analysis]
20 Tu C, Niu M, Wei AW, Tang JF, Zhang L, Jing J, Xiao XH, Wang JB. Susceptibility-Related Cytokine Panel for Prediction of Polygonum multiflorum-Induced Hepatotoxicity in Humans. J Inflamm Res 2021;14:645-55. [PMID: 33692634 DOI: 10.2147/JIR.S299892] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
21 Koen YM, Sarma D, Williams TD, Galeva NA, Obach RS, Hanzlik RP. Identification of protein targets of reactive metabolites of tienilic acid in human hepatocytes. Chem Res Toxicol 2012;25:1145-54. [PMID: 22462724 DOI: 10.1021/tx300103j] [Cited by in Crossref: 11] [Cited by in F6Publishing: 11] [Article Influence: 1.1] [Reference Citation Analysis]
22 Lu J, Roth RA, Malle E, Ganey PE. Roles of the hemostatic system and neutrophils in liver injury from co-exposure to amiodarone and lipopolysaccharide. Toxicol Sci 2013;136:51-62. [PMID: 23912913 DOI: 10.1093/toxsci/kft170] [Cited by in Crossref: 4] [Cited by in F6Publishing: 2] [Article Influence: 0.4] [Reference Citation Analysis]
23 Li C, Niu M, Bai Z, Zhang C, Zhao Y, Li R, Tu C, Li H, Jing J, Meng Y, Ma Z, Feng W, Tang J, Zhu Y, Li J, Shang X, Zou Z, Xiao X, Wang J. Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum. Front Med 2017;11:253-65. [PMID: 28315126 DOI: 10.1007/s11684-017-0508-9] [Cited by in Crossref: 36] [Cited by in F6Publishing: 32] [Article Influence: 7.2] [Reference Citation Analysis]
24 Weaver RJ, Betts C, Blomme EAG, Gerets HHJ, Gjervig Jensen K, Hewitt PG, Juhila S, Labbe G, Liguori MJ, Mesens N, Ogese MO, Persson M, Snoeys J, Stevens JL, Walker T, Park BK. Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.Expert Opin Drug Metab Toxicol. 2017;13:767-782. [PMID: 28604124 DOI: 10.1080/17425255.2017.1341489] [Cited by in Crossref: 21] [Cited by in F6Publishing: 17] [Article Influence: 4.2] [Reference Citation Analysis]
25 Williams CD, Jaeschke H. Role of innate and adaptive immunity during drug-induced liver injury. Toxicol Res 2012;1:161. [DOI: 10.1039/c2tx20032e] [Cited by in Crossref: 12] [Cited by in F6Publishing: 4] [Article Influence: 1.2] [Reference Citation Analysis]
26 Petrov PD, Fernández-Murga ML, López-Riera M, Goméz-Lechón MJ, Castell JV, Jover R. Predicting drug-induced cholestasis: preclinical models. Expert Opin Drug Metab Toxicol 2018;14:721-38. [PMID: 29888962 DOI: 10.1080/17425255.2018.1487399] [Cited by in Crossref: 5] [Cited by in F6Publishing: 7] [Article Influence: 1.3] [Reference Citation Analysis]
27 Fredriksson L, Wink S, Herpers B, Benedetti G, Hadi M, de Bont H, Groothuis G, Luijten M, Danen E, de Graauw M, Meerman J, van de Water B. Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity. Toxicol Sci 2014;140:144-59. [PMID: 24752500 DOI: 10.1093/toxsci/kfu072] [Cited by in Crossref: 55] [Cited by in F6Publishing: 51] [Article Influence: 6.9] [Reference Citation Analysis]
28 Wells-knecht KJ, Ott GR, Cheng M, Wells GJ, Breslin HJ, Gingrich DE, Weinberg L, Mesaros EF, Huang Z, Yazdanian M, Ator MA, Aimone LD, Zeigler K, Dorsey BD. 2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation. Chem Res Toxicol 2011;24:1994-2003. [DOI: 10.1021/tx200304r] [Cited by in Crossref: 7] [Cited by in F6Publishing: 7] [Article Influence: 0.6] [Reference Citation Analysis]
29 Padberg F, Höper T, Henkel S, Driesch D, Luch A, Zellmer S. Novel indirect co-culture of immortalised hepatocytes with monocyte derived macrophages is characterised by pro-inflammatory cytokine networks. Toxicol In Vitro 2021;73:105134. [PMID: 33662514 DOI: 10.1016/j.tiv.2021.105134] [Reference Citation Analysis]
30 Gustafsson F, Foster AJ, Sarda S, Bridgland-taylor MH, Kenna JG. A Correlation Between the In Vitro Drug Toxicity of Drugs to Cell Lines That Express Human P450s and Their Propensity to Cause Liver Injury in Humans. Toxicological Sciences 2014;137:189-211. [DOI: 10.1093/toxsci/kft223] [Cited by in Crossref: 56] [Cited by in F6Publishing: 51] [Article Influence: 6.2] [Reference Citation Analysis]
31 Zhai XR, Zou ZS, Wang JB, Xiao XH. Herb-Induced Liver Injury Related to Reynoutria multiflora (Thunb.) Moldenke: Risk Factors, Molecular and Mechanistic Specifics. Front Pharmacol 2021;12:738577. [PMID: 34539416 DOI: 10.3389/fphar.2021.738577] [Reference Citation Analysis]
32 Qin N, Xu G, Wang Y, Zhan X, Gao Y, Wang Z, Fu S, Shi W, Hou X, Wang C, Li R, Liu Y, Wang J, Zhao H, Xiao X, Bai Z. Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity. Front Med 2021;15:594-607. [PMID: 33909257 DOI: 10.1007/s11684-020-0809-2] [Reference Citation Analysis]
33 Tu C, Gao D, Li XF, Li CY, Li RS, Zhao YL, Li N, Jia GL, Pang JY, Cui HR, Ma ZJ, Xiao XH, Wang JB. Inflammatory stress potentiates emodin-induced liver injury in rats. Front Pharmacol 2015;6:233. [PMID: 26557087 DOI: 10.3389/fphar.2015.00233] [Cited by in Crossref: 30] [Cited by in F6Publishing: 31] [Article Influence: 4.3] [Reference Citation Analysis]
34 Poulsen KL, Olivero-Verbel J, Beggs KM, Ganey PE, Roth RA. Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: role of the DNA damage response. J Pharmacol Exp Ther 2014;350:164-70. [PMID: 24817034 DOI: 10.1124/jpet.114.214189] [Cited by in Crossref: 21] [Cited by in F6Publishing: 20] [Article Influence: 2.6] [Reference Citation Analysis]
35 Li CY, Tu C, Gao D, Wang RL, Zhang HZ, Niu M, Li RY, Zhang CE, Li RS, Xiao XH, Yang MH, Wang JB. Metabolomic Study on Idiosyncratic Liver Injury Induced by Different Extracts of Polygonum multiflorum in Rats Integrated with Pattern Recognition and Enriched Pathways Analysis. Front Pharmacol 2016;7:483. [PMID: 28018221 DOI: 10.3389/fphar.2016.00483] [Cited by in Crossref: 29] [Cited by in F6Publishing: 29] [Article Influence: 4.8] [Reference Citation Analysis]
36 Mosedale M, Watkins PB. Understanding Idiosyncratic Toxicity: Lessons Learned from Drug-Induced Liver Injury. J Med Chem 2020;63:6436-61. [PMID: 32037821 DOI: 10.1021/acs.jmedchem.9b01297] [Cited by in Crossref: 13] [Cited by in F6Publishing: 8] [Article Influence: 6.5] [Reference Citation Analysis]
37 Ramm S, Morissey B, Hernandez B, Rooney C, Pennington SR, Mally A. Application of a discovery to targeted LC-MS proteomics approach to identify deregulated proteins associated with idiosyncratic liver toxicity in a rat model of LPS/diclofenac co-administration. Toxicology 2015;331:100-11. [PMID: 25772430 DOI: 10.1016/j.tox.2015.03.004] [Cited by in Crossref: 6] [Cited by in F6Publishing: 5] [Article Influence: 0.9] [Reference Citation Analysis]
38 Gómez-Lechón MJ, Tolosa L, Donato MT. Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs. J Appl Toxicol 2016;36:752-68. [PMID: 26691983 DOI: 10.1002/jat.3277] [Cited by in Crossref: 42] [Cited by in F6Publishing: 33] [Article Influence: 6.0] [Reference Citation Analysis]
39 Wang Z, Xu G, Wang H, Zhan X, Gao Y, Chen N, Li R, Song X, Guo Y, Yang R, Niu M, Wang J, Liu Y, Xiao X, Bai Z. Icariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation. Acta Pharm Sin B 2020;10:1619-33. [PMID: 33088683 DOI: 10.1016/j.apsb.2020.03.006] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 3.0] [Reference Citation Analysis]
40 Stagg NJ, Ghantous HN, Roth R, Hastings KL. Predictivity/Translatability of Toxicities Observed in Nonclinical Toxicology Studies to Clinical Safety Outcomes in Drug Development: Case Examples. Int J Toxicol 2020;39:141-50. [PMID: 31875744 DOI: 10.1177/1091581819894281] [Reference Citation Analysis]
41 Hammond S, Thomson P, Meng X, Naisbitt D. In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs. Front Immunol 2021;12:630530. [PMID: 33927714 DOI: 10.3389/fimmu.2021.630530] [Reference Citation Analysis]
42 Gao D, Pang JY, Zhang CE, Li CY, Tu C, Zhang HZ, Niu M, Xiong Y, Xiao XH, Zhao KJ, Gao WW, Wang JB. Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata. Front Pharmacol 2016;7:386. [PMID: 27803670 DOI: 10.3389/fphar.2016.00386] [Cited by in Crossref: 10] [Cited by in F6Publishing: 10] [Article Influence: 1.7] [Reference Citation Analysis]
43 Gao Y, Xu G, Ma L, Shi W, Wang Z, Zhan X, Qin N, He T, Guo Y, Niu M, Wang J, Bai Z, Xiao X. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Cell Commun Signal 2021;19:13. [PMID: 33573688 DOI: 10.1186/s12964-020-00647-1] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
44 Kenna JG. Human biology-based drug safety evaluation: scientific rationale, current status and future challenges. Expert Opin Drug Metab Toxicol 2017;13:567-74. [PMID: 28150517 DOI: 10.1080/17425255.2017.1290082] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 0.6] [Reference Citation Analysis]
45 Maiuri AR, Breier AB, Gora LF, Parkins RV, Ganey PE, Roth RA. Cytotoxic Synergy Between Cytokines and NSAIDs Associated With Idiosyncratic Hepatotoxicity Is Driven by Mitogen-Activated Protein Kinases. Toxicol Sci. 2015;146:265-280. [PMID: 25953702 DOI: 10.1093/toxsci/kfv091] [Cited by in Crossref: 21] [Cited by in F6Publishing: 14] [Article Influence: 3.0] [Reference Citation Analysis]
46 Hadi M, Westra IM, Starokozhko V, Dragovic S, Merema MT, Groothuis GM. Human precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury. Chem Res Toxicol. 2013;26:710-720. [PMID: 23565644 DOI: 10.1021/tx300519p] [Cited by in Crossref: 31] [Cited by in F6Publishing: 28] [Article Influence: 3.4] [Reference Citation Analysis]
47 Beggs KM, Maiuri AR, Fullerton AM, Poulsen KL, Breier AB, Ganey PE, Roth RA. Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related. Toxicology 2015;331:35-46. [PMID: 25748550 DOI: 10.1016/j.tox.2015.03.002] [Cited by in Crossref: 14] [Cited by in F6Publishing: 10] [Article Influence: 2.0] [Reference Citation Analysis]
48 Roth RA, Ganey PE. Role of Inflammation in Drug-Induced Liver Injury. Drug-Induced Liver Disease. Elsevier; 2013. pp. 157-73. [DOI: 10.1016/b978-0-12-387817-5.00010-8] [Cited by in Crossref: 2] [Article Influence: 0.2] [Reference Citation Analysis]