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For: Selkoe DJ. Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease. J Clin Invest. 2002;110:1375-1381. [PMID: 12438432 DOI: 10.1172/jci16783] [Cited by in Crossref: 7] [Cited by in F6Publishing: 61] [Article Influence: 0.4] [Reference Citation Analysis]
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7 Ofengeim D, Shi P, Miao B, Fan J, Xia X, Fan Y, Lipinski MM, Hashimoto T, Polydoro M, Yuan J. Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening. J Biol Chem. 2012;287:8714-8723. [PMID: 22277654 DOI: 10.1074/jbc.m111.290957] [Cited by in Crossref: 16] [Cited by in F6Publishing: 8] [Article Influence: 1.8] [Reference Citation Analysis]
8 Tachibana M, Holm ML, Liu CC, Shinohara M, Aikawa T, Oue H, Yamazaki Y, Martens YA, Murray ME, Sullivan PM, Weyer K, Glerup S, Dickson DW, Bu G, Kanekiyo T. APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1. J Clin Invest 2019;129:1272-7. [PMID: 30741718 DOI: 10.1172/JCI124853] [Cited by in Crossref: 40] [Cited by in F6Publishing: 20] [Article Influence: 20.0] [Reference Citation Analysis]
9 Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA. NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A 2018;115:E1876-85. [PMID: 29432159 DOI: 10.1073/pnas.1718819115] [Cited by in Crossref: 151] [Cited by in F6Publishing: 136] [Article Influence: 50.3] [Reference Citation Analysis]
10 Shah RC, Kamphuis PJ, Leurgans S, Swinkels SH, Sadowsky CH, Bongers A, Rappaport SA, Quinn JF, Wieggers RL, Scheltens P, Bennett DA. The S-Connect study: results from a randomized, controlled trial of Souvenaid in mild-to-moderate Alzheimer's disease. Alzheimers Res Ther 2013;5:59. [PMID: 24280255 DOI: 10.1186/alzrt224] [Cited by in Crossref: 60] [Cited by in F6Publishing: 44] [Article Influence: 7.5] [Reference Citation Analysis]
11 Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y. C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice. Proc Natl Acad Sci U S A 2011;108:4236-41. [PMID: 21368138 DOI: 10.1073/pnas.1018381108] [Cited by in Crossref: 46] [Cited by in F6Publishing: 44] [Article Influence: 4.6] [Reference Citation Analysis]
12 Singhrao SK, Olsen I. Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer's disease. J Oral Microbiol 2019;11:1563405. [PMID: 30728914 DOI: 10.1080/20002297.2018.1563405] [Cited by in Crossref: 64] [Cited by in F6Publishing: 51] [Article Influence: 32.0] [Reference Citation Analysis]
13 Ethell DW, Buhler LA. Fas ligand-mediated apoptosis in degenerative disorders of the brain. J Clin Immunol 2003;23:363-70. [PMID: 14601644 DOI: 10.1023/a:1025317516396] [Cited by in Crossref: 18] [Cited by in F6Publishing: 6] [Article Influence: 1.1] [Reference Citation Analysis]
14 Cardoso D, Muchir A. Need for NAD+: Focus on Striated Muscle Laminopathies. Cells 2020;9:E2248. [PMID: 33036437 DOI: 10.3390/cells9102248] [Reference Citation Analysis]
15 Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One 2015;10:e0118379. [PMID: 25710492 DOI: 10.1371/journal.pone.0118379] [Cited by in Crossref: 27] [Cited by in F6Publishing: 25] [Article Influence: 4.5] [Reference Citation Analysis]
16 Hou Y, Song H, Croteau DL, Akbari M, Bohr VA. Genome instability in Alzheimer disease. Mech Ageing Dev 2017;161:83-94. [PMID: 27105872 DOI: 10.1016/j.mad.2016.04.005] [Cited by in Crossref: 51] [Cited by in F6Publishing: 43] [Article Influence: 10.2] [Reference Citation Analysis]
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18 Marzolo MP, Bu G. Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease. Semin Cell Dev Biol 2009;20:191-200. [PMID: 19041409 DOI: 10.1016/j.semcdb.2008.10.005] [Cited by in Crossref: 71] [Cited by in F6Publishing: 66] [Article Influence: 5.5] [Reference Citation Analysis]
19 Hou Y, Wang Y, Zhao J, Li X, Cui J, Ding J, Wang Y, Zeng X, Ling Y, Shen X, Chen S, Huang C, Pei G. Smart Soup, a traditional Chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits. PLoS One 2014;9:e111215. [PMID: 25386946 DOI: 10.1371/journal.pone.0111215] [Cited by in Crossref: 25] [Cited by in F6Publishing: 19] [Article Influence: 3.6] [Reference Citation Analysis]
20 Shipley SJ, Parkin ET, Itzhaki RF, Dobson CB. Herpes simplex virus interferes with amyloid precursor protein processing. BMC Microbiol 2005;5:48. [PMID: 16109164 DOI: 10.1186/1471-2180-5-48] [Cited by in Crossref: 32] [Cited by in F6Publishing: 30] [Article Influence: 2.0] [Reference Citation Analysis]
21 Cui J, Wang X, Li X, Wang X, Zhang C, Li W, Zhang Y, Gu H, Xie X, Nan F, Zhao J, Pei G. Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis. Cell Discov 2015;1:15021. [PMID: 27462420 DOI: 10.1038/celldisc.2015.21] [Cited by in Crossref: 22] [Cited by in F6Publishing: 18] [Article Influence: 3.7] [Reference Citation Analysis]
22 Tudela R, Muñoz-Moreno E, Sala-Llonch R, López-Gil X, Soria G. Resting State Networks in the TgF344-AD Rat Model of Alzheimer's Disease Are Altered From Early Stages. Front Aging Neurosci 2019;11:213. [PMID: 31440158 DOI: 10.3389/fnagi.2019.00213] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 1.5] [Reference Citation Analysis]
23 Fu Y, Zhao J, Atagi Y, Nielsen HM, Liu CC, Zheng H, Shinohara M, Kanekiyo T, Bu G. Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan. Mol Neurodegener 2016;11:37. [PMID: 27151330 DOI: 10.1186/s13024-016-0099-y] [Cited by in Crossref: 28] [Cited by in F6Publishing: 27] [Article Influence: 5.6] [Reference Citation Analysis]
24 Sasaoka N, Sakamoto M, Kanemori S, Kan M, Tsukano C, Takemoto Y, Kakizuka A. Long-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in mice. PLoS One 2014;9:e87185. [PMID: 24489866 DOI: 10.1371/journal.pone.0087185] [Cited by in Crossref: 14] [Cited by in F6Publishing: 11] [Article Influence: 2.0] [Reference Citation Analysis]
25 Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Lopaschuk GD, Broderick TL. Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer's disease. Drug Des Devel Ther 2019;13:1197-211. [PMID: 31114160 DOI: 10.2147/DDDT.S196119] [Cited by in Crossref: 6] [Cited by in F6Publishing: 2] [Article Influence: 3.0] [Reference Citation Analysis]
26 Hung COY, Livesey FJ. Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease. Cell Rep 2018;25:3647-3660.e2. [PMID: 30590039 DOI: 10.1016/j.celrep.2018.11.095] [Cited by in Crossref: 41] [Cited by in F6Publishing: 33] [Article Influence: 20.5] [Reference Citation Analysis]
27 Janus C. Search strategies used by APP transgenic mice during navigation in the Morris water maze. Learn Mem 2004;11:337-46. [PMID: 15169864 DOI: 10.1101/lm.70104] [Cited by in Crossref: 141] [Cited by in F6Publishing: 139] [Article Influence: 8.3] [Reference Citation Analysis]
28 Norstrom EM, Zhang C, Tanzi R, Sisodia SS. Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. J Neurosci 2010;30:15677-85. [PMID: 21084623 DOI: 10.1523/JNEUROSCI.4464-10.2010] [Cited by in Crossref: 37] [Cited by in F6Publishing: 31] [Article Influence: 3.4] [Reference Citation Analysis]
29 Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM. Amyloid-beta dynamics correlate with neurological status in the injured human brain. Science 2008;321:1221-4. [PMID: 18755980 DOI: 10.1126/science.1161591] [Cited by in Crossref: 204] [Cited by in F6Publishing: 200] [Article Influence: 15.7] [Reference Citation Analysis]
30 Wen L, Tang FL, Hong Y, Luo SW, Wang CL, He W, Shen C, Jung JU, Xiong F, Lee DH, Zhang QG, Brann D, Kim TW, Yan R, Mei L, Xiong WC. VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. J Cell Biol 2011;195:765-79. [PMID: 22105352 DOI: 10.1083/jcb.201105109] [Cited by in Crossref: 160] [Cited by in F6Publishing: 155] [Article Influence: 16.0] [Reference Citation Analysis]
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32 Rosenberg PB, Lyketsos C. Mild cognitive impairment: searching for the prodrome of Alzheimer's disease. World Psychiatry 2008;7:72-8. [PMID: 18563204 DOI: 10.1002/j.2051-5545.2008.tb00159.x] [Cited by in Crossref: 34] [Cited by in F6Publishing: 25] [Article Influence: 3.4] [Reference Citation Analysis]
33 Alvarez-Arellano L, Maldonado-Bernal C. Helicobacter pylori and neurological diseases: Married by the laws of inflammation. World J Gastrointest Pathophysiol. 2014;5:400-404. [PMID: 25400983 DOI: 10.4291/wjgp.v5.i4.400] [Cited by in CrossRef: 43] [Cited by in F6Publishing: 34] [Article Influence: 6.1] [Reference Citation Analysis]
34 Biundo F, Ishiwari K, Del Prete D, D'Adamio L. Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory. Neurobiol Learn Mem 2015;126:18-30. [PMID: 26528887 DOI: 10.1016/j.nlm.2015.10.009] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 0.8] [Reference Citation Analysis]
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36 Kanekiyo T, Zhang J, Liu Q, Liu CC, Zhang L, Bu G. Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake. J Neurosci 2011;31:1644-51. [PMID: 21289173 DOI: 10.1523/JNEUROSCI.5491-10.2011] [Cited by in Crossref: 123] [Cited by in F6Publishing: 81] [Article Influence: 12.3] [Reference Citation Analysis]
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39 Ethell DW, Buhler LA. Fas ligand-mediated apoptosis in degenerative disorders of the brain. J Clin Immunol 2003;23:439-46. [PMID: 15031631 DOI: 10.1023/b:joci.0000010420.96419.a8] [Cited by in Crossref: 37] [Cited by in F6Publishing: 16] [Article Influence: 2.2] [Reference Citation Analysis]
40 Fukumoto H, Rosene DL, Moss MB, Raju S, Hyman BT, Irizarry MC. Beta-secretase activity increases with aging in human, monkey, and mouse brain. Am J Pathol 2004;164:719-25. [PMID: 14742275 DOI: 10.1016/s0002-9440(10)63159-8] [Cited by in Crossref: 186] [Cited by in F6Publishing: 102] [Article Influence: 10.9] [Reference Citation Analysis]
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42 Xu X. Gamma-secretase catalyzes sequential cleavages of the AbetaPP transmembrane domain. J Alzheimers Dis 2009;16:211-24. [PMID: 19221413 DOI: 10.3233/JAD-2009-0957] [Cited by in Crossref: 35] [Cited by in F6Publishing: 29] [Article Influence: 2.9] [Reference Citation Analysis]
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45 Prabhu Y, Burgos PV, Schindler C, Farías GG, Magadán JG, Bonifacino JS. Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing. Mol Biol Cell 2012;23:2339-51. [PMID: 22553349 DOI: 10.1091/mbc.E11-11-0944] [Cited by in Crossref: 47] [Cited by in F6Publishing: 40] [Article Influence: 5.2] [Reference Citation Analysis]
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55 Liu CC, Zhao N, Yamaguchi Y, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G. Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease. Sci Transl Med 2016;8:332ra44. [PMID: 27030596 DOI: 10.1126/scitranslmed.aad3650] [Cited by in Crossref: 62] [Cited by in F6Publishing: 65] [Article Influence: 12.4] [Reference Citation Analysis]
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57 Yi P, Schrott L, Castor TP, Alexander JS. Bryostatin-1 vs. TPPB: dose-dependent APP processing and PKC-α, -δ, and -ε isoform activation in SH-SY5Y neuronal cells. J Mol Neurosci 2012;48:234-44. [PMID: 22700373 DOI: 10.1007/s12031-012-9816-3] [Cited by in Crossref: 14] [Cited by in F6Publishing: 11] [Article Influence: 1.6] [Reference Citation Analysis]
58 Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG. Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease. Front Cell Neurosci 2015;9:191. [PMID: 26074767 DOI: 10.3389/fncel.2015.00191] [Cited by in Crossref: 146] [Cited by in F6Publishing: 152] [Article Influence: 24.3] [Reference Citation Analysis]
59 Song F, Liu T, Meng S, Li F, Zhang Y, Jiang L. Insulin-Like Growth Factor-1 Alleviates Expression of Aβ1-40 and α-, β-, and γ-Secretases in the Cortex and Hippocampus of APP/PS1 Double Transgenic Mice. J Mol Neurosci 2018;66:595-603. [PMID: 30414017 DOI: 10.1007/s12031-018-1201-4] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 2.0] [Reference Citation Analysis]
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