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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Diagnostic and prognostic value of circulating microRNAs in heart failure with preserved and reduced ejection fraction  
Christian Schulte, Dirk Westermann, Stefan Blankenberg, Tanja Zeller 
World J Cardiol 7(12):843-860. Published online Dec 26, 2015. doi: 10.4330/wjc.v7.i12.843
2
Visualization of catheter ablation for atrial fibrillation: Impact of devices and anatomy  
Mark A Benscoter, Paul A Iaizzo 
World J Cardiol 7(11):754-764. Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.754
3
Epigenetic regulation in cardiac fibrosis  
Li-Ming Yu, Yong Xu 
World J Cardiol 7(11):784-791. Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.784
4
Exercise training in the management of patients with resistant hypertension  
Fernando Ribeiro, Rui Costa, José Mesquita-Bastos 
World J Cardiol 7(2):47-51. Published online Feb 26, 2015. doi: 10.4330/wjc.v7.i2.47
5
Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure  
Katie A McCrink, Ava Brill, Anastasios Lymperopoulos 
World J Cardiol 7(9):539-543. Published online Sep 26, 2015. doi: 10.4330/wjc.v7.i9.539
6
ST-segment elevation: Distinguishing ST elevation myocardial infarction from ST elevation secondary to nonischemic etiologies  
Alok Deshpande, Yochai Birnbaum 
World J Cardiol 6(10):1067-1079. Published online Oct 26, 2014. doi: 10.4330/wjc.v6.i10.1067
7
Autonomic and endocrine control of cardiovascular function  
Richard Gordan, Judith K Gwathmey, Lai-Hua Xie 
World J Cardiol 7(4):204-214. Published online Apr 26, 2015. doi: 10.4330/wjc.v7.i4.204
8
Cardiac and non-cardiac causes of T-wave inversion in the precordial leads in adult subjects: A Dutch case series and review of the literature  
Salah AM Said, Rene Bloo, Ramon de Nooijer, Andries Slootweg 
World J Cardiol 7(2):86-100. Published online Feb 26, 2015. doi: 10.4330/wjc.v7.i2.86
9
Transcranial Doppler ultrasonography: From methodology to major clinical applications  
Antonello D’Andrea, Marianna Conte, Massimo Cavallaro, Raffaella Scarafile, Lucia Riegler, Rosangela Cocchia, Enrica Pezzullo, Andreina Carbone, Francesco Natale, Giuseppe Santoro, Pio Caso, Maria Giovanna Russo, Eduardo Bossone, Raffaele Calabrò 
World J Cardiol 8(7):383-400. Published online Jul 26, 2016. doi: 10.4330/wjc.v8.i7.383
10
Genetics of coronary artery disease and myocardial infarction  
Xuming Dai, Szymon Wiernek, James P Evans, Marschall S Runge 
World J Cardiol 8(1):1-23. Published online Jan 26, 2016. doi: 10.4330/wjc.v8.i1.1
11
Early repolarization syndrome: A cause of sudden cardiac death  
Abdi Ali, Nida Butt, Azeem S Sheikh 
World J Cardiol 7(8):466-475. Published online Aug 26, 2015. doi: 10.4330/wjc.v7.i8.466
12
Delineation of epicardial stenosis in patients with microvascular disease using pressure drop coefficient: A pilot outcome study  
Ullhas Udaya Hebbar, Mohamed A Effat, Srikara V Peelukhana, Imran Arif, Rupak K Banerjee 
World J Cardiol 9(12):813-821. Published online Dec 26, 2017. doi: 10.4330/wjc.v9.i12.813
13
Coarctation of the aorta: Management from infancy to adulthood  
Rachel D Torok, Michael J Campbell, Gregory A Fleming, Kevin D Hill 
World J Cardiol 7(11):765-775. Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.765
14
Flecainide: Current status and perspectives in arrhythmia management  
George K Andrikopoulos, Sokratis Pastromas, Stylianos Tzeis 
World J Cardiol 7(2):76-85. Published online Feb 26, 2015. doi: 10.4330/wjc.v7.i2.76
15
The role of nutrition and nutraceutical supplements in the treatment of hypertension  
Mark Houston 
World J Cardiol 6(2):38-66. Published online Feb 26, 2014. doi: 10.4330/wjc.v6.i2.38
16
Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses  
Annette Graham, Anne-Marie Allen 
World J Cardiol 7(5):277-286. Published online May 26, 2015. doi: 10.4330/wjc.v7.i5.277
17
Markers of inflammation and cardiovascular disease in recently diagnosed celiac disease patients  
Walter F Tetzlaff, Tomás Meroño, Martin Menafra, Maximiliano Martin, Eliana Botta, Maria D Matoso, Patricia Sorroche, Juan A De Paula, Laura E Boero, Fernando Brites 
World J Cardiol 9(5):448-456. Published online May 26, 2017. doi: 10.4330/wjc.v9.i5.448
18
19
Aerobic vs anaerobic exercise training effects on the cardiovascular system  
Harsh Patel, Hassan Alkhawam, Raef Madanieh, Niel Shah, Constantine E Kosmas, Timothy J Vittorio 
World J Cardiol 9(2):134-138. Published online Feb 26, 2017. doi: 10.4330/wjc.v9.i2.134
20
Drugs to be avoided in patients with long QT syndrome: Focus on the anaesthesiological management  
Giovanni Fazio, Federica Vernuccio, Giuseppe Grutta, Giuseppe Lo Re 
World J Cardiol 5(4):87-93. Published online Apr 26, 2013. doi: 10.4330/wjc.v5.i4.87
21
Recent advances in the diagnosis and treatment of acute myocardial infarction  
Koushik Reddy, Asma Khaliq, Robert J Henning 
World J Cardiol 7(5):243-276. Published online May 26, 2015. doi: 10.4330/wjc.v7.i5.243
22
Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases?  
Ashish N Rao, Nayef M Kazzaz, Jason S Knight 
World J Cardiol 7(12):829-842. Published online Dec 26, 2015. doi: 10.4330/wjc.v7.i12.829
23
24
Percutaneous assist devices in acute myocardial infarction with cardiogenic shock: Review, meta-analysis  
Francesco Romeo, Maria Cristina Acconcia, Domenico Sergi, Alessia Romeo, Simona Francioni, Flavia Chiarotti, Quintilio Caretta 
World J Cardiol 8(1):98-111. Published online Jan 26, 2016. doi: 10.4330/wjc.v8.i1.98
25
Cardiac damage in athlete’s heart: When the “supernormal” heart fails!  
Andreina Carbone, Antonello D’Andrea, Lucia Riegler, Raffaella Scarafile, Enrica Pezzullo, Francesca Martone, Raffaella America, Biagio Liccardo, Maurizio Galderisi, Eduardo Bossone, Raffaele Calabrò 
World J Cardiol 9(6):470-480. Published online Jun 26, 2017. doi: 10.4330/wjc.v9.i6.470
26
PCSK9 inhibitors: A new era of lipid lowering therapy  
Rahul Chaudhary, Jalaj Garg, Neeraj Shah, Andrew Sumner 
World J Cardiol 9(2):76-91. Published online Feb 26, 2017. doi: 10.4330/wjc.v9.i2.76
27
Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications  
Giuseppe Maiolino, Valeria Bisogni, Giacomo Rossitto, Gian Paolo Rossi 
World J Cardiol 7(10):609-620. Published online Oct 26, 2015. doi: 10.4330/wjc.v7.i10.609
28
Role of advanced glycation end products in cardiovascular disease  
Zeinab Hegab, Stephen Gibbons, Ludwig Neyses, Mamas A Mamas 
World J Cardiol 4(4):90-102. Published online Apr 26, 2012. doi: 10.4330/wjc.v4.i4.90
29
Effects of energy drinks on the cardiovascular system  
Bishoy Wassef, Michelle Kohansieh, Amgad N Makaryus 
World J Cardiol 9(11):796-806. Published online Nov 26, 2017. doi: 10.4330/wjc.v9.i11.796
30
Alcohol-induced hypertension: Mechanism and prevention  
Kazim Husain, Rais A Ansari, Leon Ferder 
World J Cardiol 6(5):245-252. Published online May 26, 2014. doi: 10.4330/wjc.v6.i5.245
31
Positive airway pressure therapy for heart failure  
Takao Kato, Shoko Suda, Takatoshi Kasai 
World J Cardiol 6(11):1175-1191. Published online Nov 26, 2014. doi: 10.4330/wjc.v6.i11.1175
32
Diagnosis and management challenges of in-stent restenosis in coronary arteries  
M Chadi Alraies, Fahed Darmoch, Ramyashree Tummala, Ron Waksman 
World J Cardiol 9(8):640-651. Published online Aug 26, 2017. doi: 10.4330/wjc.v9.i8.640
33
Global myocardial strain assessment by different imaging modalities to predict outcomes after ST-elevation myocardial infarction: A systematic review  
Abhishek Shetye, Sheraz A Nazir, Iain B Squire, Gerald P McCann 
World J Cardiol 7(12):948-960. Published online Dec 26, 2015. doi: 10.4330/wjc.v7.i12.948
34
Hematological disorders and pulmonary hypertension  
Rajamma Mathew, Jing Huang, Joseph M Wu, John T Fallon, Michael H Gewitz 
World J Cardiol 8(12):703-718. Published online Dec 26, 2016. doi: 10.4330/wjc.v8.i12.703
35
Regional variations in cardiovascular risk factors in India: India heart watch  
Rajeev Gupta, Soneil Guptha, Krishna Kumar Sharma, Arvind Gupta, Prakash Deedwania 
World J Cardiol 4(4):112-120. Published online Apr 26, 2012. doi: 10.4330/wjc.v4.i4.112
36
Digoxin: A systematic review in atrial fibrillation, congestive heart failure and post myocardial infarction  
Sebastiano Virgadamo, Richard Charnigo, Yousef Darrat, Gustavo Morales, Claude S Elayi 
World J Cardiol 7(11):808-816. Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.808
37
Takotsubo cardiomyopathy: Pathophysiology, diagnosis and treatment  
Kazuo Komamura, Miho Fukui, Toshihiro Iwasaku, Shinichi Hirotani, Tohru Masuyama 
World J Cardiol 6(7):602-609. Published online Jul 26, 2014. doi: 10.4330/wjc.v6.i7.602
38
Essential hypertension and oxidative stress: New insights  
Jaime González, Nicolás Valls, Roberto Brito, Ramón Rodrigo 
World J Cardiol 6(6):353-366. Published online Jun 26, 2014. doi: 10.4330/wjc.v6.i6.353
39
Palm oil and the heart: A review  
Osaretin J Odia, Sandra Ofori, Omosivie Maduka 
World J Cardiol 7(3):144-149. Published online Mar 26, 2015. doi: 10.4330/wjc.v7.i3.144
40
Heart failure after myocardial infarction in the era of primary percutaneous coronary intervention: Mechanisms, incidence and identification of patients at risk  
Thomas J Cahill, Rajesh K Kharbanda 
World J Cardiol 9(5):407-415. Published online May 26, 2017. doi: 10.4330/wjc.v9.i5.407
41
End-organ protection in hypertension by the novel and selective Rho-kinase inhibitor, SAR407899  
Matthias Löhn, Oliver Plettenburg, Aimo Kannt, Markus Kohlmann, Armin Hofmeister, Dieter Kadereit, Peter Monecke, Alexander Schiffer, Anke Schulte, Hartmut Ruetten, Yuri Ivashchenko 
World J Cardiol 7(1):31-42. Published online Jan 26, 2015. doi: 10.4330/wjc.v7.i1.31
42
Percutaneous left atrial appendage closure: Technical aspects and prevention of periprocedural complications with the watchman device  
Sven Möbius-Winkler, Nicolas Majunke, Marcus Sandri, Norman Mangner, Axel Linke, Gregg W Stone, Ingo Dähnert, Gerhard Schuler, Peter B Sick 
World J Cardiol 7(2):65-75. Published online Feb 26, 2015. doi: 10.4330/wjc.v7.i2.65
43
Cardiac remodeling and physical training post myocardial infarction  
Michael A Garza, Emily A Wason, John Q Zhang 
World J Cardiol 7(2):52-64. Published online Feb 26, 2015. doi: 10.4330/wjc.v7.i2.52
44
Therapeutic modification of arterial stiffness: An update and comprehensive review  
Ching-Fen Wu, Pang-Yen Liu, Tsung-Jui Wu, Yuan Hung, Shih-Ping Yang, Gen-Min Lin 
World J Cardiol 7(11):742-753. Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.742
45
Potential pathophysiological role for the vitamin D deficiency in essential hypertension  
Federico Carbone, François Mach, Nicolas Vuilleumier, Fabrizio Montecucco 
World J Cardiol 6(5):260-276. Published online May 26, 2014. doi: 10.4330/wjc.v6.i5.260
46
Cardiovascular involvement in celiac disease  
Edward J Ciaccio, Suzanne K Lewis, Angelo B Biviano, Vivek Iyer, Hasan Garan, Peter H Green 
World J Cardiol 9(8):652-666. Published online Aug 26, 2017. doi: 10.4330/wjc.v9.i8.652
47
Psoriasis, non-alcoholic fatty liver disease, and cardiovascular disease: Three different diseases on a unique background  
Giulia Ganzetti, Anna Campanati, Elisa Molinelli, Annamaria Offidani 
World J Cardiol 8(2):120-131. Published online Feb 26, 2016. doi: 10.4330/wjc.v8.i2.120
48
Arrhythmogenic ventricular cardiomyopathy: A paradigm shift from right to biventricular disease  
Ardan M Saguner, Corinna Brunckhorst, Firat Duru 
World J Cardiol 6(4):154-174. Published online Apr 26, 2014. doi: 10.4330/wjc.v6.i4.154
49
Alcoholic cardiomyopathy  
Gonzalo Guzzo-Merello, Marta Cobo-Marcos, Maria Gallego-Delgado, Pablo Garcia-Pavia 
World J Cardiol 6(8):771-781. Published online Aug 26, 2014. doi: 10.4330/wjc.v6.i8.771
50
Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4  
Azhar Maqbool, Emma J Spary, Iain W Manfield, Michaela Ruhmann, Lorena Zuliani-Alvarez, Filomena O Gamboa-Esteves, Karen E Porter, Mark J Drinkhill, Kim S Midwood, Neil A Turner 
World J Cardiol 8(5):340-350. Published online May 26, 2016. doi: 10.4330/wjc.v8.i5.340