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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
Diagnostic and prognostic value of circulating microRNAs in heart failure with preserved and reduced ejection fraction  
Christian Schulte, Dirk Westermann, Stefan Blankenberg, Tanja Zeller 
World J Cardiol 7(12):843-860. Published online Dec 26, 2015. doi: 10.4330/wjc.v7.i12.843
Visualization of catheter ablation for atrial fibrillation: Impact of devices and anatomy  
Mark A Benscoter, Paul A Iaizzo 
World J Cardiol 7(11):754-764. Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.754
Epigenetic regulation in cardiac fibrosis  
Li-Ming Yu, Yong Xu 
World J Cardiol 7(11):784-791. Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.784
Exercise training in the management of patients with resistant hypertension  
Fernando Ribeiro, Rui Costa, José Mesquita-Bastos 
World J Cardiol 7(2):47-51. Published online Feb 26, 2015. doi: 10.4330/wjc.v7.i2.47
Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure  
Katie A McCrink, Ava Brill, Anastasios Lymperopoulos 
World J Cardiol 7(9):539-543. Published online Sep 26, 2015. doi: 10.4330/wjc.v7.i9.539
ST-segment elevation: Distinguishing ST elevation myocardial infarction from ST elevation secondary to nonischemic etiologies  
Alok Deshpande, Yochai Birnbaum 
World J Cardiol 6(10):1067-1079. Published online Oct 26, 2014. doi: 10.4330/wjc.v6.i10.1067
Autonomic and endocrine control of cardiovascular function  
Richard Gordan, Judith K Gwathmey, Lai-Hua Xie 
World J Cardiol 7(4):204-214. Published online Apr 26, 2015. doi: 10.4330/wjc.v7.i4.204
Early repolarization syndrome: A cause of sudden cardiac death  
Abdi Ali, Nida Butt, Azeem S Sheikh 
World J Cardiol 7(8):466-475. Published online Aug 26, 2015. doi: 10.4330/wjc.v7.i8.466
Genetics of coronary artery disease and myocardial infarction  
Xuming Dai, Szymon Wiernek, James P Evans, Marschall S Runge 
World J Cardiol 8(1):1-23. Published online Jan 26, 2016. doi: 10.4330/wjc.v8.i1.1
Cardiac and non-cardiac causes of T-wave inversion in the precordial leads in adult subjects: A Dutch case series and review of the literature  
Salah AM Said, Rene Bloo, Ramon de Nooijer, Andries Slootweg 
World J Cardiol 7(2):86-100. Published online Feb 26, 2015. doi: 10.4330/wjc.v7.i2.86
Transcranial Doppler ultrasonography: From methodology to major clinical applications  
Antonello D’Andrea, Marianna Conte, Massimo Cavallaro, Raffaella Scarafile, Lucia Riegler, Rosangela Cocchia, Enrica Pezzullo, Andreina Carbone, Francesco Natale, Giuseppe Santoro, Pio Caso, Maria Giovanna Russo, Eduardo Bossone, Raffaele Calabrò 
World J Cardiol 8(7):383-400. Published online Jul 26, 2016. doi: 10.4330/wjc.v8.i7.383
Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses  
Annette Graham, Anne-Marie Allen 
World J Cardiol 7(5):277-286. Published online May 26, 2015. doi: 10.4330/wjc.v7.i5.277
Coarctation of the aorta: Management from infancy to adulthood  
Rachel D Torok, Michael J Campbell, Gregory A Fleming, Kevin D Hill 
World J Cardiol 7(11):765-775. Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.765
The role of nutrition and nutraceutical supplements in the treatment of hypertension  
Mark Houston 
World J Cardiol 6(2):38-66. Published online Feb 26, 2014. doi: 10.4330/wjc.v6.i2.38
Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases?  
Ashish N Rao, Nayef M Kazzaz, Jason S Knight 
World J Cardiol 7(12):829-842. Published online Dec 26, 2015. doi: 10.4330/wjc.v7.i12.829
Percutaneous assist devices in acute myocardial infarction with cardiogenic shock: Review, meta-analysis  
Francesco Romeo, Maria Cristina Acconcia, Domenico Sergi, Alessia Romeo, Simona Francioni, Flavia Chiarotti, Quintilio Caretta 
World J Cardiol 8(1):98-111. Published online Jan 26, 2016. doi: 10.4330/wjc.v8.i1.98
Flecainide: Current status and perspectives in arrhythmia management  
George K Andrikopoulos, Sokratis Pastromas, Stylianos Tzeis 
World J Cardiol 7(2):76-85. Published online Feb 26, 2015. doi: 10.4330/wjc.v7.i2.76
Markers of inflammation and cardiovascular disease in recently diagnosed celiac disease patients  
Walter F Tetzlaff, Tomás Meroño, Martin Menafra, Maximiliano Martin, Eliana Botta, Maria D Matoso, Patricia Sorroche, Juan A De Paula, Laura E Boero, Fernando Brites 
World J Cardiol 9(5):448-456. Published online May 26, 2017. doi: 10.4330/wjc.v9.i5.448
Role of advanced glycation end products in cardiovascular disease  
Zeinab Hegab, Stephen Gibbons, Ludwig Neyses, Mamas A Mamas 
World J Cardiol 4(4):90-102. Published online Apr 26, 2012. doi: 10.4330/wjc.v4.i4.90
Recent advances in the diagnosis and treatment of acute myocardial infarction  
Koushik Reddy, Asma Khaliq, Robert J Henning 
World J Cardiol 7(5):243-276. Published online May 26, 2015. doi: 10.4330/wjc.v7.i5.243
Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications  
Giuseppe Maiolino, Valeria Bisogni, Giacomo Rossitto, Gian Paolo Rossi 
World J Cardiol 7(10):609-620. Published online Oct 26, 2015. doi: 10.4330/wjc.v7.i10.609
PCSK9 inhibitors: A new era of lipid lowering therapy  
Rahul Chaudhary, Jalaj Garg, Neeraj Shah, Andrew Sumner 
World J Cardiol 9(2):76-91. Published online Feb 26, 2017. doi: 10.4330/wjc.v9.i2.76
Regional variations in cardiovascular risk factors in India: India heart watch  
Rajeev Gupta, Soneil Guptha, Krishna Kumar Sharma, Arvind Gupta, Prakash Deedwania 
World J Cardiol 4(4):112-120. Published online Apr 26, 2012. doi: 10.4330/wjc.v4.i4.112
Digoxin: A systematic review in atrial fibrillation, congestive heart failure and post myocardial infarction  
Sebastiano Virgadamo, Richard Charnigo, Yousef Darrat, Gustavo Morales, Claude S Elayi 
World J Cardiol 7(11):808-816. Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.808
Positive airway pressure therapy for heart failure  
Takao Kato, Shoko Suda, Takatoshi Kasai 
World J Cardiol 6(11):1175-1191. Published online Nov 26, 2014. doi: 10.4330/wjc.v6.i11.1175
Delineation of epicardial stenosis in patients with microvascular disease using pressure drop coefficient: A pilot outcome study  
Ullhas Udaya Hebbar, Mohamed A Effat, Srikara V Peelukhana, Imran Arif, Rupak K Banerjee 
World J Cardiol 9(12):813-821. Published online Dec 26, 2017. doi: 10.4330/wjc.v9.i12.813
Drugs to be avoided in patients with long QT syndrome: Focus on the anaesthesiological management  
Giovanni Fazio, Federica Vernuccio, Giuseppe Grutta, Giuseppe Lo Re 
World J Cardiol 5(4):87-93. Published online Apr 26, 2013. doi: 10.4330/wjc.v5.i4.87
Cardiac damage in athlete’s heart: When the “supernormal” heart fails!  
Andreina Carbone, Antonello D’Andrea, Lucia Riegler, Raffaella Scarafile, Enrica Pezzullo, Francesca Martone, Raffaella America, Biagio Liccardo, Maurizio Galderisi, Eduardo Bossone, Raffaele Calabrò 
World J Cardiol 9(6):470-480. Published online Jun 26, 2017. doi: 10.4330/wjc.v9.i6.470
Global myocardial strain assessment by different imaging modalities to predict outcomes after ST-elevation myocardial infarction: A systematic review  
Abhishek Shetye, Sheraz A Nazir, Iain B Squire, Gerald P McCann 
World J Cardiol 7(12):948-960. Published online Dec 26, 2015. doi: 10.4330/wjc.v7.i12.948
Percutaneous left atrial appendage closure: Technical aspects and prevention of periprocedural complications with the watchman device  
Sven Möbius-Winkler, Nicolas Majunke, Marcus Sandri, Norman Mangner, Axel Linke, Gregg W Stone, Ingo Dähnert, Gerhard Schuler, Peter B Sick 
World J Cardiol 7(2):65-75. Published online Feb 26, 2015. doi: 10.4330/wjc.v7.i2.65
Essential hypertension and oxidative stress: New insights  
Jaime González, Nicolás Valls, Roberto Brito, Ramón Rodrigo 
World J Cardiol 6(6):353-366. Published online Jun 26, 2014. doi: 10.4330/wjc.v6.i6.353
Therapeutic modification of arterial stiffness: An update and comprehensive review  
Ching-Fen Wu, Pang-Yen Liu, Tsung-Jui Wu, Yuan Hung, Shih-Ping Yang, Gen-Min Lin 
World J Cardiol 7(11):742-753. Published online Nov 26, 2015. doi: 10.4330/wjc.v7.i11.742
Effects of energy drinks on the cardiovascular system  
Bishoy Wassef, Michelle Kohansieh, Amgad N Makaryus 
World J Cardiol 9(11):796-806. Published online Nov 26, 2017. doi: 10.4330/wjc.v9.i11.796
Takotsubo cardiomyopathy: Pathophysiology, diagnosis and treatment  
Kazuo Komamura, Miho Fukui, Toshihiro Iwasaku, Shinichi Hirotani, Tohru Masuyama 
World J Cardiol 6(7):602-609. Published online Jul 26, 2014. doi: 10.4330/wjc.v6.i7.602
Impairment of aspirin antiplatelet effects by non-opioid analgesic medication  
Amin Polzin, Thomas Hohlfeld, Malte Kelm, Tobias Zeus 
World J Cardiol 7(7):383-391. Published online Jul 26, 2015. doi: 10.4330/wjc.v7.i7.383
Aerobic vs anaerobic exercise training effects on the cardiovascular system  
Harsh Patel, Hassan Alkhawam, Raef Madanieh, Niel Shah, Constantine E Kosmas, Timothy J Vittorio 
World J Cardiol 9(2):134-138. Published online Feb 26, 2017. doi: 10.4330/wjc.v9.i2.134
End-organ protection in hypertension by the novel and selective Rho-kinase inhibitor, SAR407899  
Matthias Löhn, Oliver Plettenburg, Aimo Kannt, Markus Kohlmann, Armin Hofmeister, Dieter Kadereit, Peter Monecke, Alexander Schiffer, Anke Schulte, Hartmut Ruetten, Yuri Ivashchenko 
World J Cardiol 7(1):31-42. Published online Jan 26, 2015. doi: 10.4330/wjc.v7.i1.31
Arrhythmogenic ventricular cardiomyopathy: A paradigm shift from right to biventricular disease  
Ardan M Saguner, Corinna Brunckhorst, Firat Duru 
World J Cardiol 6(4):154-174. Published online Apr 26, 2014. doi: 10.4330/wjc.v6.i4.154
Psoriasis, non-alcoholic fatty liver disease, and cardiovascular disease: Three different diseases on a unique background  
Giulia Ganzetti, Anna Campanati, Elisa Molinelli, Annamaria Offidani 
World J Cardiol 8(2):120-131. Published online Feb 26, 2016. doi: 10.4330/wjc.v8.i2.120
Hematological disorders and pulmonary hypertension  
Rajamma Mathew, Jing Huang, Joseph M Wu, John T Fallon, Michael H Gewitz 
World J Cardiol 8(12):703-718. Published online Dec 26, 2016. doi: 10.4330/wjc.v8.i12.703
Diagnosis and management challenges of in-stent restenosis in coronary arteries  
M Chadi Alraies, Fahed Darmoch, Ramyashree Tummala, Ron Waksman 
World J Cardiol 9(8):640-651. Published online Aug 26, 2017. doi: 10.4330/wjc.v9.i8.640
Angiotensin II-related hypertension and eye diseases  
Pablo Jesus Marin Garcia, Maria Encarna Marin-Castaño 
World J Cardiol 6(9):968-984. Published online Sep 26, 2014. doi: 10.4330/wjc.v6.i9.968
Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4  
Azhar Maqbool, Emma J Spary, Iain W Manfield, Michaela Ruhmann, Lorena Zuliani-Alvarez, Filomena O Gamboa-Esteves, Karen E Porter, Mark J Drinkhill, Kim S Midwood, Neil A Turner 
World J Cardiol 8(5):340-350. Published online May 26, 2016. doi: 10.4330/wjc.v8.i5.340
Cardioprotection by remote ischemic conditioning: Mechanisms and clinical evidences  
Alberto Aimo, Chiara Borrelli, Alberto Giannoni, Luigi Emilio Pastormerlo, Andrea Barison, Gianluca Mirizzi, Michele Emdin, Claudio Passino 
World J Cardiol 7(10):621-632. Published online Oct 26, 2015. doi: 10.4330/wjc.v7.i10.621
Hyponatremia in patients with heart failure  
Theodosios D Filippatos, Moses S Elisaf 
World J Cardiol 5(9):317-328. Published online Sep 26, 2013. doi: 10.4330/wjc.v5.i9.317
Palm oil and the heart: A review  
Osaretin J Odia, Sandra Ofori, Omosivie Maduka 
World J Cardiol 7(3):144-149. Published online Mar 26, 2015. doi: 10.4330/wjc.v7.i3.144
Alcoholic cardiomyopathy  
Gonzalo Guzzo-Merello, Marta Cobo-Marcos, Maria Gallego-Delgado, Pablo Garcia-Pavia 
World J Cardiol 6(8):771-781. Published online Aug 26, 2014. doi: 10.4330/wjc.v6.i8.771
Magnetic resonance imaging and multi-detector computed tomography assessment of extracellular compartment in ischemic and non-ischemic myocardial pathologies  
Maythem Saeed, Steven W Hetts, Robert Jablonowski, Mark W Wilson 
World J Cardiol 6(11):1192-1208. Published online Nov 26, 2014. doi: 10.4330/wjc.v6.i11.1192