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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Sphingosine-1-phosphate signaling in vasculogenesis and angiogenesis  
Kelley M Argraves, Brent A Wilkerson, W Scott Argraves 
World J Biol Chem 1(10):291-297. Published online Oct 26, 2010. doi: 10.4331/wjbc.v1.i10.291
2
New insights into sodium transport regulation in the distal nephron: Role of G-protein coupled receptors  
Luciana Morla, Aurélie Edwards, Gilles Crambert 
World J Biol Chem 7(1):44-63. Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.44
3
Connective tissue growth factor differentially binds to members of the cystine knot superfamily and potentiates platelet-derived growth factor-B signaling in rabbit corneal fibroblast cells  
Liya Pi, Pei-Yu Chung, Sriniwas Sriram, Masmudur M Rahman, Wen-Yuan Song, Edward W Scott, Bryon E Petersen, Gregory S Schultz 
World J Biol Chem 6(4):379-388. Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.379
4
Klotho in cardiovascular disease: Current and future perspectives  
Javier Donate-Correa, Ernesto Martín-Núñez, Carmen Mora-Fernández, Mercedes Muros-de-Fuentes, Nayra Pérez-Delgado, Juan F Navarro-González 
World J Biol Chem 6(4):351-357. Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.351
5
Recent advances in production, purification and applications of phycobiliproteins  
Ravi Raghav Sonani, Rajesh Prasad Rastogi, Rutvij Patel, Datta Madamwar 
World J Biol Chem 7(1):100-109. Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.100
6
Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host  
Vitor Sueth-Santiago, Debora Decote-Ricardo, Alexandre Morrot, Celio Geraldo Freire-de-Lima, Marco Edilson Freire Lima 
World J Biol Chem 8(1):57-80. Published online Feb 26, 2017. doi: 10.4331/wjbc.v8.i1.57
7
B-1 cells modulate the murine macrophage response to Leishmania major infection  
Angelica F Arcanjo, Marise P Nunes, Elias B Silva-Junior, Monique Leandro, Juliana Dutra Barbosa da Rocha, Alexandre Morrot, Debora Decote-Ricardo, Celio Geraldo Freire-de-Lima 
World J Biol Chem 8(2):151-162. Published online May 26, 2017. doi: 10.4331/wjbc.v8.i2.151
8
Complexity of vitamin E metabolism  
Lisa Schmölz, Marc Birringer, Stefan Lorkowski, Maria Wallert 
World J Biol Chem 7(1):14-43. Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.14
9
Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges  
Yulia Vugmeyster, Xin Xu, Frank-Peter Theil, Leslie A Khawli, Michael W Leach 
World J Biol Chem 3(4):73-92. Published online Apr 26, 2012. doi: 10.4331/wjbc.v3.i4.73
10
New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases  
Naoki Adachi, Tadahiro Numakawa, Misty Richards, Shingo Nakajima, Hiroshi Kunugi 
World J Biol Chem 5(4):409-428. Published online Nov 26, 2014. doi: 10.4331/wjbc.v5.i4.409
11
Identification of neuron selective androgen receptor inhibitors  
Maya Otto-Duessel, Ben Yi Tew, Steven Vonderfecht, Roger Moore, Jeremy O Jones 
World J Biol Chem 8(2):138-150. Published online May 26, 2017. doi: 10.4331/wjbc.v8.i2.138
12
Adipocyte activation of cancer stem cell signaling in breast cancer  
Benjamin Wolfson, Gabriel Eades, Qun Zhou 
World J Biol Chem 6(2):39-47. Published online May 26, 2015. doi: 10.4331/wjbc.v6.i2.39
13
Dysregulated lipid metabolism in cancer  
Feng Zhang, Guangwei Du 
World J Biol Chem 3(8):167-174. Published online Aug 26, 2012. doi: 10.4331/wjbc.v3.i8.167
14
Inflammation, oxidative stress and renin angiotensin system in atherosclerosis  
Kazim Husain, Wilfredo Hernandez, Rais A Ansari, Leon Ferder 
World J Biol Chem 6(3):209-217. Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.209
15
Mnk kinase pathway: Cellular functions and biological outcomes  
Sonali Joshi, Leonidas C Platanias 
World J Biol Chem 5(3):321-333. Published online Aug 26, 2014. doi: 10.4331/wjbc.v5.i3.321
16
Molecular recognition by gold, silver and copper nanoparticles  
Yannick Tauran, Arnaud Brioude, Anthony W Coleman, Moez Rhimi, Beonjoom Kim 
World J Biol Chem 4(3):35-63. Published online Aug 26, 2013. doi: 10.4331/wjbc.v4.i3.35
17
Global histone post-translational modifications and cancer: Biomarkers for diagnosis, prognosis and treatment?  
Shafqat Ali Khan, Divya Reddy, Sanjay Gupta 
World J Biol Chem 6(4):333-345. Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.333
18
KAPtain in charge of multiple missions: Emerging roles of KAP1  
Chun-Ting Cheng, Ching-Ying Kuo, David K Ann 
World J Biol Chem 5(3):308-320. Published online Aug 26, 2014. doi: 10.4331/wjbc.v5.i3.308
19
Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication  
Minjong Lee, Jung-Hwan Yoon 
World J Biol Chem 6(3):148-161. Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.148
20
Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants  
Sugreev Verma, Kousik Kesh, Nilanjan Ganguly, Sayantan Jana, Snehasikta Swarnakar 
World J Biol Chem 5(3):355-376. Published online Aug 26, 2014. doi: 10.4331/wjbc.v5.i3.355
21
Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity  
Luciano Pirola, José Candido Ferraz 
World J Biol Chem 8(2):120-128. Published online May 26, 2017. doi: 10.4331/wjbc.v8.i2.120
22
Longevity of animals under reactive oxygen species stress and disease susceptibility due to global warming  
Biswaranjan Paital, Sumana Kumari Panda, Akshaya Kumar Hati, Bobllina Mohanty, Manoj Kumar Mohapatra, Shyama Kanungo, Gagan Bihari Nityananda Chainy 
World J Biol Chem 7(1):110-127. Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.110
23
Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease  
Keith Richard Mitchelson, Wen-Yan Qin 
World J Biol Chem 6(3):162-208. Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.162
24
25
Role of microRNAs in translation regulation and cancer  
Stefania Oliveto, Marilena Mancino, Nicola Manfrini, Stefano Biffo 
World J Biol Chem 8(1):45-56. Published online Feb 26, 2017. doi: 10.4331/wjbc.v8.i1.45
26
Targeting amino acid metabolism in cancer growth and anti-tumor immune response  
Elitsa Ananieva 
World J Biol Chem 6(4):281-289. Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.281
27
Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation  
Hironori Adachi, Yi-Tao Yu 
World J Biol Chem 5(4):398-408. Published online Nov 26, 2014. doi: 10.4331/wjbc.v5.i4.398
28
S100B protein in tissue development, repair and regeneration  
Guglielmo Sorci, Francesca Riuzzi, Cataldo Arcuri, Claudia Tubaro, Roberta Bianchi, Ileana Giambanco, Rosario Donato 
World J Biol Chem 4(1):1-12. Published online Feb 26, 2013. doi: 10.4331/wjbc.v4.i1.1
29
Modern trends in animal venom research - omics and nanomaterials  
Yuri N Utkin 
World J Biol Chem 8(1):4-12. Published online Feb 26, 2017. doi: 10.4331/wjbc.v8.i1.4
30
Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalk  
Yvonne E Smith, Sri HariKrishna Vellanki, Ann M Hopkins 
World J Biol Chem 7(1):64-77. Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.64
31
Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism  
Barbara Triggs-Raine, Marvin R Natowicz 
World J Biol Chem 6(3):110-120. Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.110
32
Disruption of NAD+ binding site in glyceraldehyde 3-phosphate dehydrogenase affects its intranuclear interactions  
Manali Phadke, Natalia Krynetskaia, Anurag Mishra, Carlos Barrero, Salim Merali, Scott A Gothe, Evgeny Krynetskiy 
World J Biol Chem 6(4):366-378. Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.366
33
Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction  
Yutaka Matsui, Junko Morimoto, Toshimitsu Uede 
World J Biol Chem 1(5):69-80. Published online May 26, 2010. doi: 10.4331/wjbc.v1.i5.69
34
Effect of paricalcitol and enalapril on renal inflammation/oxidative stress in atherosclerosis  
Kazim Husain, Edu Suarez, Angel Isidro, Wilfredo Hernandez, Leon Ferder 
World J Biol Chem 6(3):240-248. Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.240
35
Characterization of two alkyl hydroperoxide reductase C homologs alkyl hydroperoxide reductase C_H1 and alkyl hydroperoxide reductase C_H2 in Bacillus subtilis  
Mee-Kyung Cha, Yoo-Jeen Bae, Kyu-Jeong Kim, Byung-Joon Park, Il-Han Kim 
World J Biol Chem 6(3):249-264. Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.249
36
Transforming growth factor-β and smooth muscle differentiation  
Xia Guo, Shi-You Chen 
World J Biol Chem 3(3):41-52. Published online Mar 26, 2012. doi: 10.4331/wjbc.v3.i3.41
37
Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca2+ signaling pathway  
Wenjie Wei, Richard Graeff, Jianbo Yue 
World J Biol Chem 5(1):58-67. Published online Feb 26, 2014. doi: 10.4331/wjbc.v5.i1.58
38
API2-MALT1 oncoprotein promotes lymphomagenesis via unique program of substrate ubiquitination and proteolysis  
Shaun Rosebeck, Megan S Lim, Kojo S J Elenitoba-Johnson, Linda M McAllister-Lucas, Peter C Lucas 
World J Biol Chem 7(1):128-137. Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.128
39
Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence  
Mai Fujimoto, Yasunobu Mano, Motonobu Anai, Shogo Yamamoto, Masaki Fukuyo, Hiroyuki Aburatani, Atsushi Kaneda 
World J Biol Chem 7(1):188-205. Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.188
40
Retroviral integrase protein and intasome nucleoprotein complex structures  
Julia Grawenhoff, Alan N Engelman 
World J Biol Chem 8(1):32-44. Published online Feb 26, 2017. doi: 10.4331/wjbc.v8.i1.32
41
Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals: From experimental models to clinical trials  
Girish B Maru, Rasika R Hudlikar, Gaurav Kumar, Khushboo Gandhi, Manoj B Mahimkar 
World J Biol Chem 7(1):88-99. Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.88
42
Promise and challenges on the horizon of MET-targeted cancer therapeutics  
Yu-Wen Zhang 
World J Biol Chem 6(2):16-27. Published online May 26, 2015. doi: 10.4331/wjbc.v6.i2.16
43
High levels of homocysteine downregulate apolipoprotein E expression via nuclear factor kappa B  
Violeta G Trusca, Adina D Mihai, Elena V Fuior, Ioana M Fenyo, Anca V Gafencu 
World J Biol Chem 7(1):178-187. Published online Feb 26, 2016. doi: 10.4331/wjbc.v7.i1.178
44
Molecular basis of cleft palates in mice  
Noriko Funato, Masataka Nakamura, Hiromi Yanagisawa 
World J Biol Chem 6(3):121-138. Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.121
45
Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer  
Sherri Rennoll, Gregory Yochum 
World J Biol Chem 6(4):290-300. Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.290
46
Chromatin boundary elements organize genomic architecture and developmental gene regulation in Drosophila Hox clusters  
Zhibo Ma, Mo Li, Sharmila Roy, Kevin J Liu, Matthew L Romine, Derrick C Lane, Sapna K Patel, Haini N Cai 
World J Biol Chem 7(3):223-230. Published online Aug 26, 2016. doi: 10.4331/wjbc.v7.i3.223
47
Mechanisms of the alternative activation of macrophages and non-coding RNAs in the development of radiation-induced lung fibrosis  
Nadire Duru, Benjamin Wolfson, Qun Zhou 
World J Biol Chem 7(4):231-239. Published online Nov 26, 2016. doi: 10.4331/wjbc.v7.i4.231
48
Multifunctional facets of retrovirus integrase  
Duane P Grandgenett, Krishan K Pandey, Sibes Bera, Hideki Aihara 
World J Biol Chem 6(3):83-94. Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.83
49
Lack of new antiinfective agents: Passing into the pre-antibiotic age?  
Klaus Brandenburg, Tobias Schürholz 
World J Biol Chem 6(3):71-77. Published online Aug 26, 2015. doi: 10.4331/wjbc.v6.i3.71
50
Anticancer actions of PPARγ ligands: Current state and future perspectives in human lung cancer  
Shou Wei Han, Jesse Roman 
World J Biol Chem 1(3):31-40. Published online Mar 26, 2010. doi: 10.4331/wjbc.v1.i3.31