Copyright ©2010 Baishideng Publishing Group Co.
World J Biol Chem. Jan 26, 2010; 1(1): 13-20
Published online Jan 26, 2010. doi: 10.4331/wjbc.v1.i1.13
Figure 2
Figure 2 Mechanisms of Tax activation of the canonical and noncanonical NF-κB pathways. In the canonical pathway, Tax interacts with TAX1BP1 to disrupt the formation and function of the A20 ubiquitin-editing complex. Ubiquitinated Tax interacts with IKKγ and activates the canonical NF-κB pathway. Tax triggers activation of the noncanonical pathway downstream of NIK by recruiting IKKα to p100 thus stimulating phosphorylation, ubiquitination, and processing to p52.