Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Mar 27, 2016; 8(3): 212-221
Published online Mar 27, 2016. doi: 10.4240/wjgs.v8.i3.212
Duodenal adenocarcinoma: Advances in diagnosis and surgical management
Jordan M Cloyd, Elizabeth George, Brendan C Visser
Jordan M Cloyd, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States
Elizabeth George, Brendan C Visser, Department of Surgery, Stanford University, Stanford, CA 94305, United States
Author contributions: Cloyd JM, George E and Visser BC contributed solely to this manuscript.
Conflict-of-interest statement: The authors report no relevant conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Jordan M Cloyd, MD, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1400 Pressler St, FCT 17.6055, Houston, TX 77030, United States.
Telephone: +1-713-7920029 Fax: +1-713-7453039
Received: August 26, 2015
Peer-review started: August 30, 2015
First decision: October 27, 2015
Revised: November 2, 2015
Accepted: December 13, 2015
Article in press: December 15, 2015
Published online: March 27, 2016


Duodenal adenocarcinoma is a rare but aggressive malignancy. Given its rarity, previous studies have traditionally combined duodenal adenocarcinoma (DA) with either other periampullary cancers or small bowel adenocarcinomas, limiting the available data to guide treatment decisions. Nevertheless, management primarily involves complete surgical resection when technically feasible. Surgery may require pancreaticoduodenectomy or segmental duodenal resection; either are acceptable options as long as negative margins are achievable and an adequate lymphadenectomy can be performed. Adjuvant chemotherapy and radiation are important components of multi-modality treatment for patients at high risk of recurrence. Further research would benefit from multi-institutional trials that do not combine DA with other periampullary or small bowel malignancies. The purpose of this article is to perform a comprehensive review of DA with special focus on the surgical management and principles.

Key Words: Duodenal cancer, Duodenal adenocarcinoma, Periampullary, Whipple, Pancreaticoduodenectomy, Segmental resection, Small bowel

Core tip: Duodenal adenocarcinoma is a rare but aggressive malignancy. Complete surgical resection is recommended when technically feasible. Pancreaticoduodenectomy or segmental duodenal resection may be employed, depending on the tumor location, and either are acceptable options as long as negative margins and adequate lymphadenectomy can be achieved. Although specific data are limited, adjuvant chemotherapy and radiation should be considered for patients at high risk of recurrence.


Although the majority of small bowel adenocarcinomas arise in the duodenum, duodenal adenocarcinoma (DA) still represents less than 1% of all gastrointestinal cancers[1,2]. Not surprisingly, given the rarity of the disease, there is limited data to guide treatment decisions. Early studies grouped DA with other periampullary tumors (pancreatic, ampullary, distal bile duct) when discussing their management options. However, in general, DA has a more favorable outcome. For example, compared to some other periampullary malignancies, DA is more likely to be amenable to curative resection and has more favorable long term outcomes[3]. As a result, treatment strategies have tended to favor aggressive surgical resection. The purpose of this article is to provide a comprehensive review of the epidemiology, presentation, diagnosis, management and prognosis of DA with a special emphasis on surgical principles.


Small bowel malignancies are relatively rare, accounting for only 2% of all gastrointestinal cancers in the United States[4]. Among small bowel tumors, most malignancies arise from the ileum, followed by the duodenum and lastly the jejunum. While most tumors of the ileum are neuroendocrine in origin, adenocarcinoma is the most common duodenal cancer[4-6]. One large population-based analysis found the duodenum to be the location of 55.7% of adenocarcinomas of the small bowel[5]. The majority of DA arise in the second portion of the duodenum, followed by D3/D4, with cancers of the first portion of the duodenum, especially the duodenal bulb, extremely rare[7,8].

The causative factors for DA have not been clearly identified. Dietary factors, such as increased intake of bread, pasta, sugar and red meat or reduced intake of fruits and vegetables, are risk factors for small bowel adenocarcinoma (SBA) as they are for colorectal cancer[9]. Ingestion of alcohol, coffee and use of tobacco also seem to be risk factors[10]. Nevertheless, the strength of these associations are small and the majority of cases of DA are not associated with any known causative agents. However, duodenal adenomas, such as those that occur in familial adenomatous polyposis (FAP) and Gardner syndrome, are associated with elevated risk of DA[11,12]. Similarly, patients with duodenal polyps are also at increased risk[13]. Although less investigated than in colon cancer, the adenoma-carcinoma sequence is still largely accepted in SBA as well[14,15].


Since patients do not typically present until tumors have grown to sufficient size to cause symptoms, the diagnosis of DA is difficult and often delayed. When symptoms do appear they are nonspecific and include abdominal pain, nausea, vomiting, fatigue, weakness, and weight loss. Anemia, gastrointestinal obstruction and jaundice are symptoms associated with advanced disease. Abdominal pain is the most common presenting symptom, associated with 56% of cases[16]. As a result of these delays in diagnosis, many cases of DA are not resectable at presentation due to local and distant invasion. Less often, patients undergoing screening programs may be found to have early DA or even adenoma with dysplasia before symptoms begin[17].


Since early symptoms are typically vague, most patients initially undergo either esophagogastroduodenoscopy or cross sectional imaging. Endoscopy is the preferred diagnostic modality as it allows simultaneous visualization and biopsy. Evaluation by an experienced endoscopist is critical as examination of the entire duodenum is required. While lesions in the third or fourth portion of the duodenum can be technically challenging to view endoscopically, the use of extra-long fiber optic scopes may be helpful[18]. Lesions in the distal duodenum may be missed on initial endoscopic evaluation, resulting in further diagnostic delays. Careful attention to proximity of pertinent structures such as the ampulla of Vater should be given. Endoscopic ultrasound may be performed simultaneously to evaluate local extension or lymphadenopathy. In addition, it may facilitate tissue diagnosis when attempts at luminal biopsy are not successful. Upper gastrointestinal series with oral contrast may facilitate precise localization, evaluate for obstruction and rule out other causes of patients’ symptoms. Contrast-enhanced computed tomography is important for assessing involvement of nearby structures, determining resectability and planning surgery. In cases without a confirmed diagnosis, sensitive but non-specific radiographic features suggestive of malignancy include an exophytic or intramural mass, central necrosis and ulceration[19]. While the role of conventional abdominal ultrasound is limited, especially for tumors < 2 cm in size, lesions appear as irregularly marginated hypoechoic masses[20].


Diagnosis of DA requires a thorough histopathologic examination of tissue specimens. Adenocarcinoma of gastric, pancreas, distal bile duct and ampullary origin must be ruled out. The degree of associated dysplasia should be assessed. Among extra-ampullary DA, several distinct subtypes have been described: intestinal, gastric, pancreaticobiliary and indeterminate (Table 1)[21,22]. Interestingly, intestinal type DA has been associated with more favorable prognosis compared to other histological subtype[22-24]. Variable expression of the classic cytokeratin markers CK7 and CK20 have made them largely unhelpful in diagnosing DA[25,26]. However, CDX2, a sensitive marker for colorectal carcinoma, is more often expressed in DA and SBA[25,27]. Expression of Her2 in DA has been inconsistently reported in the literature[25,28], perhaps because expression may be limited to gastric subtypes of DA[22]. Conversely, Overman et al[25] found EGFR and VEGF expression rates of 71% and 91%, respectively, in a large series of SBA which was primarily comprised of DA.

Table 1 Histopathologic subtypes of duodenal adenocarcinoma.
PhenotypeHistological characteristicsHistologically similarImmunophenotype markersPrognosis
IntestinalTubular/cribiforming glands lined by columnar neoplastic cellsColonic adenocarcinomaMUC2, CD10, CDX2+
GastricTubular/papillary proliferation with foveolar or pyloric-type differentiationGastric adenocarcinomaMUC5AC, MUC6-
PancreaticobiliarySimple glands of cuboidal/columnar cells with rounded pleomorphic nuclei; prominent desmoplastic stromaPancreatic and Extrahepatic bile duct adenocarcinomaMUC1-
IndeterminatePoor differentiationNoneMUC1-

Staging of DA is based on the 7th edition of the American Joint Committee on Cancer’s TNM staging system that was published in 2010 (Table 2)[29]. Accurate nodal staging depends on adequate lymphadenectomy at the time of surgery[30,31].

Table 2 7th edition of the American Joint Committee on Cancer’s staging system for small bowel adenocarcinoma.
Primary tumor (T)Regional lymph nodes (N)Distant metastases (M)
Tx - Primary tumor cannot be assessedNx - Regional lymph nodes cannot be assessedMx - Distant metastases not assessed
Tis - Carcinoma in situN0 - No regional node metastasisM0 - Distant metastases not present
T1a - Tumor invades lamina propriaN1 - Metastasis in 1-3 regional nodesM1 - Distant metastases present
T1b - Tumor invades submucosaN2 - Metastasis in 4 or more regional nodes
T2 - Tumor invades muscularis propriaStage grouping
T3 - Tumor invades into the subserosaStage 0TisN0M0
Stage IT1-T2N0M0
T4 - Tumor perforates visceral peritoneum; or invades pancreas/bile ductStage IIAT3N0M0
Stage IIBT4N0M0
Stage IIIAAny TN1M0
Stage IIIBAny TN2M0
Stage IVAny TAny NM1
Relevant anatomy

The duodenum is the first of portion of the small intestine and functions as a conduit between the stomach and the jejunum while regulating the emptying of gastric contents and enzymatically breaking down the chyme received from the stomach. The surgical management of duodenal cancers varies by the portion of the duodenum involved, and hence the basic anatomic divisions merit review. The first segment of the duodenum is suspended by the hepatoduodenal ligament, lies intraperitoneally, begins caudal to the pylorus and extends 5 cm to the duodenal flexure. Moving retroperitoneally, the second segment spans approximately 7.5 cm and is fixed to and curves around the head of the pancreas to travel medially at the level of L3. The transverse, or third, portion of the duodenum is 10 cm in length and lies anterior to the aorta and inferior vena cava but posterior to the superior mesenteric vein and artery. The ascending, or fourth, segment of the duodenum is approximately 2.5 cm in length and heads superior and laterally to become intraperitoneal again as it reaches the ligament of Treitz at the anatomical boundary of the duodenojejunal junction.

Surgical approach

Tumors located in the second portion of the duodenum typically require pancreaticoduodenectomy (PD) because of proximity to head of the pancreas, distal bile duct and ampulla of Vater. Conversely, tumors occurring in the first, third or fourth portion of the duodenum may be managed by either PD or segmental resection (SR). Some will argue that PD should be used for all DAs, regardless of location, to ensure wide margins and adequate regional lymphadenectomy. This opinion is based on the results of early series reporting few long-term survivors of SR[32-39]. Still others will argue for SR of tumors in either the very proximal or very distal duodenum provided that wide margins can be achieved[40-42] in order to avoid the morbidity of PD. Most studies that compared outcomes of two approaches found no statistically significant difference in outcomes, but were limited by small sample sizes and retrospective design[13,42-48]. Cloyd et al[49] recently utilized the surveilance, epidemiology and end results database to retrospectively compare the outcomes of radical resection (defined as a resection of the primary duodenal tumor en bloc with an adjacent organ, as is performed in PD) vs SR across a population-based cohort of patients with DA. In this study of 1611 patients from 1988 to 2010, radical resection was associated with a greater number of LNs excised but not improved survival (Figure 1). Although PD may be required for technical reasons in some situations, the study suggests that SR is an appropriate strategy as long as negative margins can be obtained[49].

Figure 1
Figure 1 Outcomes of surgery for duodenal adenocarcinoma based on type of surgery. Used with permission: Cloyd et al[49].

Regardless of the approach, an R0 resection remains the most important goal for surgery with curative attempt. Margin status directly impacts outcomes. Sohn et al[35] reported the Johns Hopkins experience and showed a 5 year OS of 58% in margin negative patients vs 0% in margin positive patients. Similarly, Poultsides et al[50] reviewed the Memorial Sloan Kettering Cancer Center (MSKCC) experience and found 5 year OS rates of 55% and 0% among R0 and R1 patients, respectively.


The importance of an adequate lymphadenectomy cannot be underscored. Sarela et al[51] were among the first to report improved prognostic abilities of the N staging system with higher number of lymph nodes retrieved. In fact, a greater lymph node retrieval has independently been associated with improved survival for patients with DA[2,31,49]. Although the American Joint Committee on Cancer has recommended a minimum pathologic evaluation of 6 lymph nodes, several authors have questioned whether this minimum number should be raised[50,52]. Intuitively, one might expect operations that enable a better lymphadenectomy, such as a classic PD vs a pylorus-preserving PD or PD vs SR, would therefore be associated with improved survival. However, this has not been found to be the case, either in randomized controlled trials[53] or population-based analyses[49]. Although the reasons behind why greater lymph node retrieval is associated with improved survival may be complex and multifactorial, it is likely primarily secondary to improved stage stratification and prognostication.

Palliative surgery

Among patients with localized DA, approximately 43%-87% will have resectable disease[54]. Of the remainder, some will require palliation. The goals of palliative surgery for DA may include relief of gastric outlet obstruction, relief of biliary obstruction and/or pain relief. Operative interventions for gastroduodenal obstruction may include gastrojejunostomy or duodenojejunostomy; either may be constructed in a roux-en-y or loop fashion. Minimally invasive approaches are possible in the correct context. Surgery for biliary obstruction typically involves a roux-en-y hepaticojejunostomy. A 13-year prospective study from the United Kingdom examining surgery for DA found that of the 178 patients included in the study, 150 underwent surgery with curative intention and 28 underwent surgery for palliation. Of those who received palliation, 15 had a gastrojejunostomy, 9 had a double bypass and 4 underwent an exploratory laparotomy without further intervention. Median survival in the palliative surgery group was 8 mo. Not surprisingly, those who undergo palliative surgery are more likely to have a larger tumor, greater degree of invasiveness, as well as regional and distant metastases[55]. For patients who are not already undergoing surgical exploration and require palliation for enteral or biliary obstruction, endoscopically placed duodenal and biliary stents, when technically feasible, are preferable to avoid laparotomy given the limited prognosis.

Pancreas-preserving total duodenectomy

Although a comprehensive discussion is outside the scope of this review article, pancreas-preserving total duodenectomy (PPTD) has emerged as an alternative to PD or SR for patients with benign or pre-malignant conditions of the duodenum, most commonly in the setting of FAP. After total proctocolectomy, upper gastrointestinal cancers are the most common cause of death in patients with FAP[56]. Intense screening programs utilizing duodenoscopy with endoscopic polypectomy have proven effective in reducing the incidence of DA in this high risk population[57]. In patients with diffuse polyposis or Spigelman stage IV disease, however, prophylactic duodenectomy may be indicated[56,58,59]. Several techniques of PPTD have been described[60-63] including minimally invasive options[64]. Despite the advantages of organ preservation, short term morbidity and mortality rates remain high[65]. It is important to note that invasive carcinoma in FAP patients should be treated similarly to sporadic DA with either PD or SR (as described above) in order to ensure adequate margins and lymphadenectomy. Pylorus-preserving PD should be avoided in patients with FAP as the residual duodenal bulb remains at risk for new polyp and carcinoma formation[66].


Unfortunately, little data is currently available to inform the choice of adjuvant chemotherapy following complete surgical resection. The ESPAC-3 trial was a phase 3, multi-institutional, randomized controlled trial comparing observation vs adjuvant fluorouracil vs adjuvant gemcitabine in patients with periampullary cancers (ampullary, bile duct, duodenal or other) who underwent PD with R0 or R1 resection status. Although median survival was not significantly different between the observation and adjuvant therapy groups in the primary analysis (35 mo vs 43 mo), adjuvant chemotherapy was associated with improved OS after multivariable regression (HR = 0.75, 95%CI: 0.57-0.98)[67]. Importantly, periampullary DA comprised a small subset of this study’s population and extra-ampullary DA was not included.

Given its rarity, most therapeutic studies have traditionally combined DA with either other periampullary cancers or small bowel adenocarcinomas. For this reason, chemotherapeutic regimens are not standardized, but increasingly DA is being treated similar to colorectal adenocarcinoma with oxaliplatin-based chemotherapy. Given the tendency of this disease to recur systemically, the role of adjuvant chemotherapy warrants further investigation. Current practice at many centers is to treat patients with high risk features (e.g., nodal metastasis) with oxaliplatin-based chemotherapy[50].

Definitive, or palliative, chemotherapy should be offered to all eligible patients with metastatic or unresectable disease. A phase II prospective trial studied 30 patients with metastatic or unresectable small bowel or ampullary adenocarcinoma who received capecitabine and oxaliplatin and noted a 50% overall response rate, 10% complete response. Median time to progression was 11 mo with median overall survival 20 mo[68,69]. Patients should also be considered for clinical trials as appropriate.


The role of adjuvant radiotherapy in the treatment of DA is not well defined. No studies have demonstrated an effect on OS with the use of chemoradiotherapy (CRT). One small study of 14 patients from Johns Hopkins with node-positive DA treated with PD and adjuvant CRT (median dose of 50 Gy, concurrent 5-FU) resulted in improved local control compared with surgery alone (93% vs 67%)[70]. Similarly, a retrospective study of 32 patients from Duke University Medical Center was able to show modest improvement in local control (70% vs 49%) with adjuvant CRT[71]. Unfortunately, neither study showed that adjuvant chemoradiation contributed to improved overall survival: 5-year survival 44% vs 43%[70] and 44% vs 57%[71], respectively. Other retrospective series have shown similar results with improvements in locoregional control but not OS[72]. Nevertheless, this approach targeting improved locoregional control may make CRT particularly useful in patients with lymph node metastases. In a study of 122 patients at a single institution who underwent curative resection for DA, adjuvant CRT in patients with a higher prevalence of regional lymph node metastases was associated with a similar overall survival to that of a group of patients with limited or no nodal metastases who did not receive adjuvant therapy[50].

Short term

Surgery for DA can be associated with significant morbidity and mortality. Poultsides et al[50] in their contemporary series of PD at MSKCC, reported a postoperative morbidity rate of 35% and 30-d mortality rate of 2.4%. Solaini et al[48] published a postoperative complication rate of 40% and in-hospital mortality rate of 3.3% for all patients undergoing surgery for DA. In these studies, postoperative pancreatic fistulae (POPF) developed following PD in 14.0% and 10.6% of patients, respectively[48,50]. The impact of the type of resection on postoperative outcomes is controversial. Some have suggested that SR is associated with improved outcomes as it avoids the opportunity for POPF. Tocchi et al[13] reviewed their series of 47 patients undergoing surgery for DA and found SR to be associated with less postoperative morbidity, mortality and length of hospital stay. Bakaeen et al[44] found similar complication rates but shorter LOS in the patients undergoing SR. Other studies have failed to find an effect of surgery type on complication rates[43,48]. The occurrence of a postoperative complication may be associated with worse long term survival[73].

Long term

DA represents an aggressive cancer but in patients with resectable disease, long term outcomes are better than with other periampullary malignancies. In a retrospective study of 122 patients who underwent PD for DA over a 22 year period at MSKCC, ten-year OS was 41%[50]. A prospective cohort study of 150 patients from six United Kingdom hepatopancreaticobiliary centers undergoing curative intent surgery for DA from 2000-2013 found 1-, 3- and 5-year OS rates of 83.9%, 66.7% and 51.2%, respectively. Median disease-free survival was 53 mo[48]. A recent population-based study suggested worse outcomes with 5-year OS rates of 65.9%, 50.4%, 31.4%, and 11.9% for Stage I, II, III and IV, respectively (Figure 2)[49]. Patients with metastatic or unresectable disease have median survival that ranges from 2-8 mo[68,69,74,75].

Figure 2
Figure 2 Stage-based disease free (A) and overall (B) survival for patients undergoing surgery for duodenal cancer based on seer data. Used with permission: Cloyd et al[49].
Prognostic factors

Factors associated with worse outcome in DA include patient age, distant metastasis, lymph node metastasis, lymph node ratio, number of lymph nodes harvested, high tumor grade, tumor (T) stage, margin status, lymphovascular or perineural invasion, and overall cancer stage (Table 3). Lymph node metastasis remains one of the most important prognostic determinants[41,43,44,49-51,74,76-78]. In the largest single institution series of 122 patients who underwent PD for DA, the presence of lymph node metastases was the only independent predictor of decreased survival in multivariate analysis. Five-year survival for node negative (N0) patients was 68% compared to 17% in patients with N2 disease[50]. Another study calculated 3-year survival for node negative patients to be 87.5% compared to only 21% in patients with nodal disease[74]. LNR, the ratio of positive LNs to number of LNs excised, may be even a more accurate predictor of prognosis[2,31,49].

Table 3 Series reporting factors associated with worse survival in duodenal adenocarcinoma.
Ref.Study periodTotal No. of patientsNo. of patients resected (%)PD5-year overall survivalafter resection (%)Negative predictors of survival
Solaini et al[48]2000-2013178150 (84.2)13243T stage, grade, AJCC stage, perineural invasion, size, age-Lymphovascular invasion, nodal metastasis
Poultsides et al[50]1984-2006122122 (100)12248T stage, tumor gradeTumor grade, positive margins, perineural invasion, nodal metastasis, vascular invasionNodal metastasis
Onkendi et al[79]1994-200912499 (79.8)7037Tumor size, positive nodes, surgical approach, adjuvant therapy-T stage and pathologic grade
Cecchini et al[80]1982-2010169103 (60.9)8742T stage, nodal metastasis, grade, AJCC stage, lymphovascular invasion, size, age-Perineural invasion
Liang et al[77]1993-20103636 (100)31NAT stage, grade, AJCC stage, lymphovascular invasion, perineural invasion, sizeAge > 75, body weight loss, nodal metastasisNodal metastasis
Malleo et al[73]2000-20093725 (67)25711T stage, nodal metastasis, AJCC stage, lymphovascular invasion, perineural invasion, size, age-Tumor grade, lack of post-operative complications
Zhang et al[16]1995-20089159 (65)NA491T stage, grade, AJCC stage, lymphovascular invasion, perineural invasion, size, age-Nodal metastasis, positive margins
Han et al[81]1990-20063228 (88)1830-Positive margins-
Struck et al[78]1989-20063030 (100)25332Positive margins, T stage, adjuvant therapyNodal metastasis, stage
Lee et al[74]1995-20075328 (53)2644Age, gender, weight loss, CA19-9, grade, tumor sizeT stage, nodal metastasis, AJCC stageNodal metastasis
Hurtuk et al[82]1984-20055235 (67)24NAGrade, positive margins, nodal metastasis, venous or perineural invasionStage T4, tumor size < 3.5 cm-
Hu et al[47]NA4328 (65)1127-Positive margins-
Sarela et al[51]1983-200013772 (52.5)56711Gender, grade, T stageAge, nodal metastasisAge, nodal metastasis
Tocchi et al[13]1980-20004725 (53)923T stage, grade, AJCC stage, lymphovascular invasion, perineural invasion, positive margins, size, age-Nodal metastasis
Ryder et al[83]1957-19984931 (63)2743Nodal metastases, location in duodenum, type of resection, adjuvant chemoradiation-Tumor size, histologic grade, transmural invasion
Kaklamanos et al[43]1978-19986337 (59)2630Age, gender, grade, T stageNodal metastasisNodal metastasis
Bakaeen et al[44]1976-199610168 (67)5054Histologic grade, tumor size, location in duodenum, adjuvant chemoradiationAge, weight loss, T stage, nodal metastasis, AJCC stageWeight loss, positive margins, nodal metastasis, AJCC stage
Sohn et al[35]1984-19965548 (87)3553Nodal metastasis, adjuvant chemoradiation, tumor size, histologic gradePositive margins, segmental resection, tumor in third/fourth portion of duodenum-
Sexe et al[76]1987-19918534 (40)3123AJCC Stage--
Rotman et al[84]1978-19886646 (70)3845Gender, age, weight loss, jaundice, T stage, tumor size, pancreatic invasion nodal metastasis, location of metastatic nodes--
Delcore et al[85]1960-19903528 (80)2160-GI bleeding, symptomatic > 4 mo, nodal metastasis-
Barnes et al[40]1967-19916736 (54)2754Nodal metastasisStage
Lowell et al[42]1970-19911717 (100)845-First/second portion of the duodeum-
Ouriel et al[33]1950-19816519 (29)130-Histologic grade, nodal metastasis-

Duodenal adenocarcinoma is a rare but aggressive malignancy. Because of the nonspecific symptoms it presents with and the difficulty in confirming a diagnosis, patients may often present with advanced disease. Nonetheless, aggressive surgical resection, when possible, affords the best chance at survival. The decision of whether to perform pancreaticoduodenectomy vs segmental resection depends on the location of the primary tumor as both are acceptable options as long as negative margins can be safely obtained. Lymph node positivity is one of the most important prognostic indicators and a wide lymphadenectomy should be routinely performed. Although data are limited guiding adjuvant therapy options, oxaliplatin-based chemotherapy is typically offered to high risk patients, such as those with positive lymph nodes. In some series, adjuvant radiation is associated with improved local control but no difference in overall survival. Previous research on DA has been limited by small sample sizes and single institutional design. Further research would benefit from multi-institutional trials that do not combined DA with other periampullary or small bowel malignancies.


P- Reviewer: Stift A, Tonelli F S- Editor: Qi Y L- Editor: A E- Editor: Wu HL

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