• artificial intelligence
• bibliometric
• machine learning
• review
• traditional Chinese medicine

• National Natural Science Foundation of China
• the Shanghai Key Laboratory of Health Identification and Assessment

• Chinese herbal medicine
• Chronic gastritis
• Liver-stomach disharmony
• Microcosmic syndrome differentiation
• Microcosmic syndrome scores
• Randomized controlled trial

• Deep learning
• Intelligent diagnosis
• Machine learning
• Traditional Chinese medicine

• Humans
• Medicine, Chinese Traditional/methods
• Artificial Intelligence
• Smell
• Machine Learning
• Palpation

• deep learning
• joint learning
• multi-task learning
• syndrome differentiation

• China
• Humans
• Language
• Medicine, Chinese Traditional/methods
• Neural Networks, Computer
• Syndrome

• diagnostic system
• dimensionality reduction
• machine learning
• pattern identification
• syndrome differentiation
• traditional Asian medicine
• traditional Chinese medicine

As modern science and technology constantly progresses, the fields of artificial intelligence, mixed reality technology, remote technology, etc. have rapidly developed. Meanwhile, these technologies have been gradually applied to the medical field, leading to the development of intelligent medicine. What’s more, intelligent medicine has greatly promoted the development of traditional Chinese medicine (TCM), causing huge changes in the diagnosis of TCM ailments, remote treatment, teaching, etc. Therefore, there are both opportunities and challenges for inheriting and developing TCM. Herein, the related research progress of intelligent medicine in the TCM in China and abroad over the years is analyzed, with the purpose of introducing the present application status of intelligent medicine in TCM and providing reference for the inheritance and development of TCM in a new era.

• development
• intelligent medicine
• traditional Chinese medicine

• Extreme learning machine
• Fuzzy mathematics
• Particle swarm
• Primary liver cancer
• Syndrome type

Intelligent traditional Chinese medicine (TCM) has become a popular research field by means of prospering of deep learning technology. Important achievements have been made in such representative tasks as automatic diagnosis of TCM syndromes and diseases and generation of TCM herbal prescriptions. However, one unavoidable issue that still hinders its progress is the lack of labeled samples, i.e., the TCM medical records. As an efficient tool, the named entity recognition (NER) models trained on various TCM resources can effectively alleviate this problem and continuously increase the labeled TCM samples. In this work, on the basis of in-depth analysis, we argue that the performance of the TCM named entity recognition model can be better by using the character-level representation and tagging and propose a novel word-character integrated self-attention module. With the help of TCM doctors and experts, we define 5 classes of TCM named entities and construct a comprehensive NER dataset containing the standard content of the publications and the clinical medical records. The experimental results on this dataset demonstrate the effectiveness of the proposed module.

• Computational diagnosis
• Smart healthcare
• Survey
• Traditional Chinese medicine

• Humans
• Algorithms
• China
• Drugs, Chinese Herbal
• Medicine, Chinese Traditional
• Syndrome

• deep learning
• lung cancer
• medical record
• model fusion
• syndrome differentiation
• traditional Chinese medicine

Artificial intelligence–based assistive diagnostic systems imitate the deductive reasoning process of a human physician in biomedical disease diagnosis and treatment decision making. While impressive progress in this area has been reported, most of the reported successes are applications of artificial intelligence in Western medicine. The application of artificial intelligence in traditional Chinese medicine has lagged mainly because traditional Chinese medicine practitioners need to perform syndrome differentiation as well as biomedical disease diagnosis before a treatment decision can be made. Syndrome, a concept unique to traditional Chinese medicine, is an abstraction of a variety of signs and symptoms. The fact that the relationship between diseases and syndromes is not one-to-one but rather many-to-many makes it very challenging for a machine to perform syndrome predictions. So far, only a handful of artificial intelligence–based assistive traditional Chinese medicine diagnostic models have been reported, and they are limited in application to a single disease-type.

The objective was to develop an artificial intelligence–based assistive diagnostic system capable of diagnosing multiple types of diseases that are common in traditional Chinese medicine, given a patient’s electronic health record notes. The system was designed to simultaneously diagnose the disease and produce a list of corresponding syndromes.

Unstructured freestyle electronic health record notes were processed by natural language processing techniques to extract clinical information such as signs and symptoms which were represented by named entities. Natural language processing used a recurrent neural network model called bidirectional long short-term memory network–conditional random forest. A convolutional neural network was then used to predict the disease-type out of 187 diseases in traditional Chinese medicine. A novel traditional Chinese medicine syndrome prediction method—an integrated learning model—was used to produce a corresponding list of probable syndromes. By following a majority-rule voting method, the integrated learning model for syndrome prediction can take advantage of four existing prediction methods (back propagation, random forest, extreme gradient boosting, and support vector classifier) while avoiding their respective weaknesses which resulted in a consistently high prediction accuracy.

A data set consisting of 22,984 electronic health records from Guanganmen Hospital of the China Academy of Chinese Medical Sciences that were collected between January 1, 2017 and September 7, 2018 was used. The data set contained a total of 187 diseases that are commonly diagnosed in traditional Chinese medicine. The diagnostic system was designed to be able to detect any one of the 187 disease-types. The data set was partitioned into a training set, a validation set, and a testing set in a ratio of 8:1:1. Test results suggested that the proposed system had a good diagnostic accuracy and a strong capability for generalization. The disease-type prediction accuracies of the top one, top three, and top five were 80.5%, 91.6%, and 94.2%, respectively.

The main contributions of the artificial intelligence–based traditional Chinese medicine assistive diagnostic system proposed in this paper are that 187 commonly known traditional Chinese medicine diseases can be diagnosed and a novel prediction method called an integrated learning model is demonstrated. This new prediction method outperformed all four existing methods in our preliminary experimental results. With further improvement of the algorithms and the availability of additional electronic health record data, it is expected that a wider range of traditional Chinese medicine disease-types could be diagnosed and that better diagnostic accuracies could be achieved.

• AI
• BiLSTM-CRF
• CNN
• ML
• NLP
• TCM
• artificial intelligence
• assistive diagnostic system
• convolutional neural network
• disease diagnosis
• machine learning
• natural language processing
• syndrome differentiation
• syndrome prediction
• traditional Chinese medicine

• Deep Learning
• Humans
• Models, Molecular
• Receptor for Advanced Glycation End Products/antagonists & inhibitors
• Receptor for Advanced Glycation End Products/metabolism
• Small Molecule Libraries/chemistry
• Small Molecule Libraries/pharmacology
• Software

• acupuncture
• data mining
• network analysis
• pattern identification

• 2017 KIOM Undergraduate Research Program Korea Institute of Oriental Medicine

• Convolutional neural networks
• End-to-end
• FastText
• Syndrome differentiation
• Text classification
• Traditional Chinese medicine
• Yang deficiency
• Yin deficiency

• Adult
• Algorithms
• Data Mining
• Databases, Factual
• Deep Learning
• Female
• Humans
• Male
• Medicine, Chinese Traditional/methods
• Middle Aged
• Syndrome
• Yang Deficiency/diagnosis
• Yin Deficiency/diagnosis
• Yin-Yang

Body constitution classification is the basis and core content of traditional Chinese medicine constitution research. It is to extract the relevant laws from the complex constitution phenomenon and finally build the constitution classification system. Traditional identification methods have the disadvantages of inefficiency and low accuracy, for instance, questionnaires. This paper proposed a body constitution recognition algorithm based on deep convolutional neural network, which can classify individual constitution types according to face images. The proposed model first uses the convolutional neural network to extract the features of face image and then combines the extracted features with the color features. Finally, the fusion features are input to the Softmax classifier to get the classification result. Different comparison experiments show that the algorithm proposed in this paper can achieve the accuracy of 65.29% about the constitution classification. And its performance was accepted by Chinese medicine practitioners.

As a complementary and alternative medicine in medical field, traditional Chinese medicine (TCM) has drawn great attention in the domestic field and overseas. In practice, TCM provides a quite distinct methodology to patient diagnosis and treatment compared to western medicine (WM). Syndrome (ZHENG or pattern) is differentiated by a set of symptoms and signs examined from an individual by four main diagnostic methods: inspection, auscultation and olfaction, interrogation, and palpation which reflects the pathological and physiological changes of disease occurrence and development. Patient classification is to divide patients into several classes based on different criteria. In this paper, from the machine learning perspective, a survey on patient classification issue will be summarized on three major aspects of TCM: sign classification, syndrome differentiation, and disease classification. With the consideration of different diagnostic data analyzed by different computational methods, we present the overview for four subfields of TCM diagnosis, respectively. For each subfield, we design a rectangular reference list with applications in the horizontal direction and machine learning algorithms in the longitudinal direction. According to the current development of objective TCM diagnosis for patient classification, a discussion of the research issues around machine learning techniques with applications to TCM diagnosis is given to facilitate the further research for TCM patient classification.