Three-dimensional-arterial spin labeling perfusion correlation with diabetes-associated cognitive dysfunction and vascular endothelial growth factor in type 2 diabetes mellitus rat
Ju-Wei Shao, Qian He, Wei Su, Shu-Tian Xiang, Jian-Bo Li, Department of Radiology, The Second People’s Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming 650021, Yunnan Province, China
Ju-Wei Shao, College of Public Health, Kunming Medical University, Kunming 650500, Yunnan Province, China
Jin-De Wang, College of Clinical Medicine, Kunming Medical University, Kunming 650500, Yunnan Province, China
Ying Yang, Department of Endocrinology and Metabolism, The Second People’s Hospital of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming 650021, Yunnan Province, China
Ying-Ying Zou, Department of Pathology and Pathophysiology, Kunming Medical University, Kunming 650021, Yunnan Province, China
Jing Fang, Institute for Health Sciences, Kunming Medical University, Kunming 650500, Yunnan Province, China
Author contributions: Shao JW designed experiments, performed the literature review, and wrote the draft of the paper; Wang JD and Zou YY helped establish the type 2 diabetes mellitus rat models and assisted in the histopathologic procedures; Li JB scanned the rats; Su W collected the data; He Q and Xiang ST corrected the data; Yang Y also contributed to the writing and editing of the manuscript, which was critically revised and edited by Fang J; All authors approved the final version.
Supported by The Endocrine Clinical Medical Center of Yunnan Province, No. ZX20190202; the Fund of the Diabetic Innovation Team in Yunnan Province, No. 2019HC002; the Special Joint Fund from Yunnan Provincial Department of Science and Technology and Kunming Medical University, Kunming, Yunnan, China, No. 2018FE001(-267); and the SKY Image Research Fund, China, No. Z-2014-07-2003-12.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals (Kunming Medical University Institutional Review Board, Approval No. kmmu 2020410).
Conflict-of-interest statement: No potential conflicts of interest.
Data sharing statement: Technical appendix, statistical code, and data set available from the corresponding author at email@example.com. Participants gave informed consent for data sharing. No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Fang, MD, Professor, Institute for Health Sciences, Kunming Medical University, No. 1168 Chunrong West Road, Yuhua Street, Chenggong District, Kunming 650031, Yunnan Province, China. firstname.lastname@example.org
Received: December 11, 2020
Peer-review started: December 11, 2020
First decision: January 11, 2021
Revised: January 12, 2021
Accepted: March 7, 2021
Article in press: March 7, 2021
Published online: April 15, 2021