Anti program death-1/anti program death-ligand 1 in digestive cancers

doi:10.4251/wjgo.v7.i8.95

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Aug 15, 2015 (publication date) through Apr 18, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Aug 15, 2015; 7(8): 95-101
Published online Aug 15, 2015. doi: 10.4251/wjgo.v7.i8.95

Table 1 Ongoing anti program death-1 or anti program death-ligand 1 monoclonal antibodies clinical trials in digestive cancers

Monoclonal antibody	Antibody description	Association	Tumors
MPDL3280A	Anti-PD-L1 Engineered	MODUL trial: Phase III biomarker driven maintenance therapy	Metastatic colorectal cancer
	Human
	IgG1¹
Medi 4736	Anti-PD-L1	None	Immunological subsets of advanced colorectal cancer
	Engineered
	Human
	IgG1¹
Nivolumab	Anti-PD-1	Nab-paclitaxel +/- Gemcitabine	Pancreatic cancer
	Fully human
	IgG4²
		GVAX pancreas vaccine + CRS-207	Pancreatic cancer
		None	Squamous cell carcinoma of the anal canal
		Ipilimumab	Recurrent and metastatic colon cancer
		None	Hepatocellular carcinoma
		None	Advanced or recurrent gastric cancer
Pembrolizumab	Anti-PD-1	None	Resectable or borderline resectable pancreas cancer
	Humanized
	IgG4²
		None	Advanced gastro-intestinal cancers
		None	Metastastic colorectal cancer with and without microsatellite instability

¹Engineered Fc domain prevent antibody dependent cell mediated cytotoxicity (ADCC);

²IgG4 antibody do not induce ADCC. PD-1: Program death-1; PD-L1: Program death-ligand 1; Ig: Immunoglobulin; GVAX: Granulocyte-macrophage colony-stimulating factor–secreting allogeneic pancreatic tumor cells, induces T-cell immunity to cancer antigens, including mesothelin; CRS-207: Live-attenuated L monocytogenes-expressing mesothelin.

Citation: Guillebon E, Roussille P, Frouin E, Tougeron D. Anti program death-1/anti program death-ligand 1 in digestive cancers. World J Gastrointest Oncol 2015; 7(8): 95-101
URL: https://www.wjgnet.com/1948-5204/full/v7/i8/95.htm
DOI: https://dx.doi.org/10.4251/wjgo.v7.i8.95