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Copyright ©The Author(s) 2015.
World J Gastrointest Oncol. Nov 15, 2015; 7(11): 328-337
Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.328
Table 1 List of association studies between polymorphisms in mucin genes and development of gastric cancer
GeneRef.PopulationDiseaseStudy designSample (case/control)PolymorphismAssociation
MUC1Vinall et al[28]EuropeanH. pylori related gastritisCase–control study57 gastritis patientsVNTRYes
Carvalho et al[34]PortugueseGCCase–control study159/324VNTRYes
Silva et al[35]PortugueseCAG, IMCase–control study174 patientsVNTRYes
Abnet et al[37]ChineseGCGWAS1625/2100rs4072037Yes
Replication: 615/1202No
Combined: 2240/3302No
Saeki et al[39]JapaneseDGCCase–control study606/1264/rs4072037, rs2070803Yes
Japanese304/1465rs4072037, rs2070803Yes
South Korean452/372rs4072037, rs2070803Yes
Xu et al[40]ChineseGCCase–control study138/241rs4072037Yes
Jia et al[43]PolishGCCase–control study (tag SNP approach)273/377rs6427184Yes
rs4971052Yes
rs4276913Yes
rs4971088Yes
rs4971092Yes
rs4072037Yes
Jia et al[43]PolishH. pylori infectionCase–control study (tag SNP approach)320/57rs6427184No
rs4971052No
rs4276913No
rs4971088No
rs4971092No
rs4072037No
Zhang et al[44]ChineseGCCase–control study1681/1858rs4072037Yes
Palmer et al[45]CaucasianGCCase–control study596/587rs4072037Yes
Li et al[46]ChineseGCCase–control study300/300rs2070803Yes
Zhang et al[47]ChineseNon-cardia GCCase–control study288/281rs4072037No
(tag SNP approach)rs2990245No
rs9628662No
rs9426886No
Zhang et al[47]ChineseH. pylori infectionCase–control study122/159rs4072037No
(tag SNP approach)rs2990245No
rs9628662No
rs9426886No
Frank et al[48]GermanCAGCase–control study533/1054rs4072037No
Marín et al[49]SpanishGCPLsCase–control study387 patientsrs3814316No
(tag SNP approach)rs9426886No
rs1045253No
Sun et al[50]Hispanic AmericanGCCase–control study132/125rs4072037No
Duan et al[51]-GCMeta-analysis4220/6384rs4072037Yes
Zheng et al[52]-GCMeta-analysis6580/10324rs4072037Yes
Mocellin et al[42]AsianDGCMeta-analysis7279 subjectsrs2070803Yes
MUC5ACJia et al[43]PolishGCCase–control study (tag SNP approach)273/377rs1541314No
rs2014486Yes
rs2075859No
rs2672785No
rs2735733Yes
rs7118568No
rs868903Yes
rs4963049No
Jia et al[43]PolishH. pylori infectionCase–control study (tag SNP approach)320/57rs1541314No
rs2014486No
rs2075859No
rs2672785No
rs2735733No
rs7118568No
rs868903No
rs4963049No
Zhou et al[61]ChineseNon-cardia GCCase–control study (tag SNP approach)288/281rs3793966No
rs7118568No
rs868903No
rs3793964Yes
rs3750919No
rs5743942No
rs4963062No
rs885454Yes
rs6578810No
rs11040869Yes
rs7118481No
rs7105198No
Zhou et al[62]ChineseH. pylori infectionCase–control study122/159rs3793966No
(tag SNP approach)rs7118568No
rs868903No
rs3793964No
rs3750919No
rs5743942No
rs4963062No
rs885454No
rs6578810No
rs11040869No
rs7118481No
rs7105198No
Wang et al[63]ChineseGCCase–control study230/328VNTRYes
MUC6Nguyen et al[68]-H. pylori infectionCase–control study92/68VNTRYes
Garcia et al[69]PortugueseGCCase–control study157/376VNTRYes
Kwon et al[70]South KoreanGCCase–control study470/1103VNTRYes
Jia et al[43]PolishGCCase–control study (tag SNP approach)273/377rs1128413No
rs4077293No
rs7483870No
rs7943115No
rs11602663No
rs11605303No
rs10902076No
rs2071174No
rs11245936No
rs10794359No
rs7112267No
rs12574439No
rs7119740No
rs11601642No
Jia et al[43]PolishH. pylori infectionCase–control study (tag SNP approach)320/57rs1128413No
rs4077293No
rs7483870No
rs7943115No
rs11602663No
rs11605303No
rs10902076No
rs2071174No
rs11245936No
rs10794359No
rs7112267No
rs12574439No
rs7119740No
rs11601642No
Marín et al[49]SpanishGCPLsCase–control study387 patientsrs4076950No
(tag SNP approach)rs7481521No
rs11246384No
rs6597947No
rs9794921No
Frank et al[48]GermanCAGCase–control study533/1054rs7481521No
MUC2Jeong et al[72]South KoreanGCCase–control study455/457VNTRYes
Marín et al[49]SpanishGCPLsCase–control study387 patientsrs10902073Yes
(tag SNP approach)rs10794281Yes
rs2856082No
rs2071174Yes
rs7396030No
rs11245936No
rs7944723Yes
rs6421972No
rs10794293Yes
rs11245954No
rs7480563No
rs7126405No
rs3924453Yes
rs4077759Yes
Frank et al[48]GermanCAGCase–control study533/1054rs2856111No
rs11825977No