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©The Author(s) 2024.
World J Gastrointest Oncol. Sep 15, 2024; 16(9): 3980-3993
Published online Sep 15, 2024. doi: 10.4251/wjgo.v16.i9.3980
Published online Sep 15, 2024. doi: 10.4251/wjgo.v16.i9.3980
Figure 2 Stimulation with 3CKs induces senescence in cancer-associated fibroblasts.
A: Primary cultures of cancer-associated fibroblasts (CAFs) isolated from pancreatic tumor tissue were established; B: The isolated and cultured primary cells showed strong expression of α-SMA; C: Stimulation with 3CKs inhibited the growth of CAFs; D: The growth rate of CAFs significantly decreased after stimulation with 3CKs; E-G: The expression of p21 and p16 significantly increased after stimulating CAFs with 3CKs; H: The depletion of Lamin B1 was observed in 3CKs-treated CAFs; I-P: Treatment with 3CKs induced upregulation of senescence-associated secretory phenotype factors. The scale bar represents 20 µm. aP < 0.05, bP < 0.01, cP < 0.001.
- Citation: Jiang H, Wang GT, Wang Z, Ma QY, Ma ZH. Resveratrol inhibits pancreatic cancer proliferation and metastasis by depleting senescent tumor-associated fibroblasts. World J Gastrointest Oncol 2024; 16(9): 3980-3993
- URL: https://www.wjgnet.com/1948-5204/full/v16/i9/3980.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v16.i9.3980