Multicenter phase II trial of modified FOLFIRINOX in gemcitabine-refractory pancreatic cancer

Table 1 Baseline characteristics

Characteristics of the patients		n = 48	Percent
Age (yr)	median (IQR)	63.5 (57.5-69.0)
	40-49	4	8.3
	50-59	10	20.8
	60-69	25	52.1
	70-79	9	18.8
Sex	Male	23	47.9
	Female	25	52.1
ECOG-PS	0	22	45.8
	1	24	50
	2	2	4.2
Duration since diagnosis (mo)	median (IQR)	7.0 (3.0-12.0)
Location of pancreatic cancer	Head	18	37.5
	Body and tail	17	35.4
	Recurrence after resection	13	27.1
Number of metastatic site	0	10	20.8
	1	18	37.5
	2	14	29.2
	≥ 3	6	12.5
Metastatic sites (> 5%)	Liver	28	58.3
	Peritoneum	16	33.3
	Distant lymph node	8	16.7
	Lung	6	12.5
Level of CA 19-9	Normal	10	20.8
	> ULN	38	79.2
Prior GEM CTx	GEM monotherapy	6	12.5
	GEM + Erlotinib	38	79.2
	GEM + Capecitabine	2	4.2
	GEM + Cisplatin	1	2.1
	GEM + Nab-paclitaxel	1	2.1
Period of prior CTx (mo)	median (IQR)	4.1 (1.9-7.8)
Prior treatment other than CTx	Operation	13	27.1
	CCRT	6	12.5

IQR: Interquartile range; ECOG-PS: Eastern Cooperative Oncology Group-performance status; CA 19-9: Carbohydrate antigen 19-9; GEM: Gemcitabine; ULN: Upper limit of the normal range; CCRT: Concurrent chemo-radiotherapy; CTx: Chemotherapy.