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World J Gastrointest Oncol. Jun 15, 2025; 17(6): 107414
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.107414
Artificial intelligence to predict hepatocellular carcinoma risk in cirrhosis
Imen Akkari, Hanen Akkari, Raida Harbi
Imen Akkari, Department of Gastroenterology, University Hospital of Hached, University of Sousse, Faculty of Medicine of Sousse, Sousse 4000, Tunisia
Hanen Akkari, LATIS-Laboratory of Advanced Technology and Intelligent Systems, University of Sousse, National School of Engineering of Sousse, Sousse 4023, Tunisia
Raida Harbi, Department of Gastroenterology, University Hospital of Sahloul, University of Sousse, Faculty of Medicine of Sousse, Sousse 4054, Tunisia
Author contributions: Akkari I and Akkari H conceptualized and designed the report; Akkari I, Akkari H, and Harbi R wrote the manuscript; Harbi R performed the literature review; All authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Imen Akkari, MD, Associate Professor, Department of Gastroenterology, University Hospital of Hached, University of Sousse, Faculty of Medicine of Sousse, Rue Mohamed Karoui, Sousse 4000, Tunisia. imenakkaribm@gmail.com
Received: March 24, 2025
Revised: April 14, 2025
Accepted: May 20, 2025
Published online: June 15, 2025
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Core Tip

Core Tip: Hepatocellular carcinoma (HCC) is a global health problem and cirrhosis is the principal risk factor for its development. Early diagnosis of HCC is associated with a better prognosis because curative treatment is feasible. The recommended screening strategy for patients with cirrhosis is ultrasound evaluation twice per year. However, the risk estimation of HCC is not the same in patients with cirrhosis, and as such risk stratification scores have been a focus of study in this population. The application of artificial intelligence has shown promise in screened patients with cirrhosis who are at the highest risk of developing HCC.