Pellegrino R, Gravina AG. Advancement of haemostatic self-assembling peptides in the treatment of gastrointestinal bleeding: What role for PuraStat®? World J Gastrointest Endosc 2025; 17(5): 107183 [DOI: 10.4253/wjge.v17.i5.107183]
Corresponding Author of This Article
Antonietta Gerarda Gravina, MD, PhD, Associate Professor, Division of Hepatogastroenterology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. de Crecchio, Naples 80138, Campania, Italy. antoniettagerarda.gravina@unicampania.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. May 16, 2025; 17(5): 107183 Published online May 16, 2025. doi: 10.4253/wjge.v17.i5.107183
Advancement of haemostatic self-assembling peptides in the treatment of gastrointestinal bleeding: What role for PuraStat®?
Raffaele Pellegrino, Antonietta Gerarda Gravina
Raffaele Pellegrino, Antonietta Gerarda Gravina, Division of Hepatogastroenterology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples 80138, Campania, Italy
Author contributions: Pellegrino R and Gravina AG collected the literature, wrote the initial manuscript, conceptualised the table, conceptualised the structure of the text, critically revised the manuscript for important intellectual content, and read and approved the final version.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Antonietta Gerarda Gravina, MD, PhD, Associate Professor, Division of Hepatogastroenterology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L. de Crecchio, Naples 80138, Campania, Italy. antoniettagerarda.gravina@unicampania.it
Received: March 18, 2025 Revised: April 2, 2025 Accepted: April 23, 2025 Published online: May 16, 2025 Processing time: 55 Days and 21.2 Hours
Abstract
PuraStat® is a novel self-assembling peptide (SAP) used as a haemostatic agent in endoscopy, with widespread application in surgical settings. While the current evidence, though deserving further expansion, demonstrates a good haemostatic performance profile for this substance, there remains significant heterogeneity among studies, and an analysis of this SAP as monotherapy is not always available. The recent study by Bellester et al in the World Journal of Gastrointestinal Endoscopy provided an optimal effectiveness profile of this SAP in 45 patients treated for gastrointestinal (GI) bleeding, particularly highlighting data on its use as monotherapy in upper GI bleeding. This invited article outlines the current evidence on PuraStat® and offers a commentary on the recently published study.
Core Tip: PuraStat® is a novel self-assembling peptide haemostatic agent used in digestive endoscopy. This commentary summarises the efficacy and safety profile of PuraStat® as discernible from the current literature, focusing on the study published in the World Journal of Gastrointestinal Endoscopy, highlighting its potential role and the need for further investigation.
