Bone metastases as initial presentation of hepatocellular carcinoma

Table 1 Cases of bone metastases debuting as unknown hepatocellular carcinoma published in the literature

Ref.	Year	n	Location	Survival1
Nowak et al[4]	1983	1	Rib	NR
Fueyo Margareto et al[5]	1986	1	Multiples bones	NR
Raoul et al[6]	1995	3	Skull	27 mo (alive)
			Iliac bone	31 mo (alive)
			Femur	31 mo (dead)2
Horita et al[7]	1996	1	Breastbone	9 mo (alive)2
Iosca et al[8]	1998	1	Left iliac bone	> 45 mo (alive)2
Soto et al[9]	2000	1	Rib	28 mo (alive)
Hofmann et al[10]	2003	1	Chest wall	12 mo (alive)2
Qureshi et al[11]	2005	1	Chest wall	NR
Hyun et al[12]	2006	1	Rib and third thoracic vertebrae	12 mo (alive)2
Rastogi et al[13]	2013	1	Scapula and occipital bone	2 mo (alive)2
Ruiz-Morales et al[14]	2014	2	Vertebrae, ribs, sacrum, scapula	NR
			Cervical vertebrae, right shoulder	NR
Hwang et al[15]	2015	1	Vertebral body and iliac bone	8 mo (alive)
Subasinghe et al[16]	2015	1	Occipital bone	NR
Alauddin et al[17]	2016	1	Left anterior chest wall	NR
Monteserín	2017	3	Iliac bone	42 mo (alive)
			Femur	41 mo (dead)
			Vertebral bodies	20 mo (dead)

¹From first sign of disease;

²From diagnosis. NR: Survival not reported.