Renal failure in cirrhosis: Emerging concepts

Table 2 Risk, injury, failure, loss of kidney function and end-stage kidney disease classification for acute kidney injury

Class	Baseline SCr levels and GFR within 7 d	Urinary output
Risk	↑ SCr 1.5-1.9 times over baseline or ↓ GFR > 25%	< 0.5 mL/kg per hour for 6 h
Injury	↑ SCr 2.0-2.9 times over baseline or ↓ GFR > 50%	< 0.5 mL/kg per hour for 12 h
Failure	↑ SCr ≥ 3 times over baseline or ↓ GFR > 75% or if baseline SCr ≥ 4 mg/dL: ↑ SCr > 0.5 mg/dL	< 0.3 mL/kg per hour for 24 h or anuria for 12 h
Loss of kidney function	Complete loss of kidney function > 4 wk
End-stage kidney disease	Complete loss of kidney function > 3 mo

Adapted from Bellomo et al[20]. GFR: Glomerular filtration rate; SCr: Serum creatinine.