Copyright ©The Author(s) 2015.
World J Hepatol. Jun 28, 2015; 7(12): 1632-1651
Published online Jun 28, 2015. doi: 10.4254/wjh.v7.i12.1632
Table 2 Currently used and investigational serum tumour markers[101]
MarkersCharacterCut-off levelSensitivitySpecificityComments
AFPOncofoetal glycoprotein10-16 ng/dL60%-80%70%-90%Poor marker alone
20 ng/dL39%-66%76%-97%
AFP-L3AFP variant (subtype)10%39.9%93.4%Useful in combination
15%36.1%-96%92%-99.5%with other markers
GP73Golgi-specific membrane protein10 relative units69%86%Promising marker
GPC3Oncofoetal glycoprotein2 ng/dL51%90%Limited utility as a marker
DCPAbnormal prothrombin40 mAU/mL48%-62%81%-98%Useful in combination
HS-GGTAbnormal prothrombin5.5 IU/mL43.8%-74%Not availableNon specific
AFULysosomal enzyme870 nmol/mL per hour82%71%Lower specificity and poor marker