Non-alcoholic fatty liver disease in 2015

Table 1 Brunt classification of steatohepatitis[27]

Grades of NASH
Grade 1 (mild)	Steatosis up to 66%. Occasional ballooned hepatocytes predominantly in zone 3. Scattered intra-acinar neutrophils
Grade 2 (moderate)	Steatosis of any degree. Ballooned hepatocytes predominantly in zone 3. Intra-acinar neutrophils. Zone 3 perisinusoidal fibrosis. Mild to moderate portal and intra-acinar chronic inflammation
Grade 3 (severe)	Panacinar steatosis. Widespread ballooned hepatocytes predominantly in zone 3. Intra-acinar inflammation. Scattered neutrophils associated with ballooned hepatocytes. Mild to moderate portal inflammation
Stages of NASH
Stage 1	Extensive zone 3 perisinusoidal fibrosis
Stage 2	Zone 3 perisinusoidal and portal or periportal fibrosis
Stage 3	Bridging fibrosis
Stage 4	Cirrhosis

NASH: Non-alcoholic steatohepatitis.