Copyright ©2010 Baishideng.
World J Hepatol. Jun 27, 2010; 2(6): 208-220
Published online Jun 27, 2010. doi: 10.4254/wjh.v2.i6.208
Figure 3
Figure 3 Vasodilation/contractile signaling in vascular smooth muscle cells. The contractile state of vascular smooth muscle depends on the phosphorilation state of myosin light chains (MLCs). Under normal conditions, contractile agonists activate G protein couple receptors (GPCR). These receptors subsequently activate downstream effectors such as phospholipase C (PLC) and GTPase RhoA, leading to the increase of MLC phosphorilation via the activation of MLC kinase or the inhibition of MLC phosphatase. DAG: diacylglycerol; IP3: inositol triphosphate; PIP2: Phosphatidylinositol 4,5-bisphosphate; PKC: protein kinase C.