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For: Wang Z, Luo X, Anene-Nzelu C, Yu Y, Hong X, Singh NH, Xia L, Liu S, Yu H. HepaRG culture in tethered spheroids as an in vitro three-dimensional model for drug safety screening. J Appl Toxicol 2015;35:909-17. [PMID: 25512232 DOI: 10.1002/jat.3090] [Cited by in Crossref: 36] [Cited by in F6Publishing: 36] [Article Influence: 4.0] [Reference Citation Analysis]
Number Citing Articles
1 Yang S, Ooka M, Margolis RJ, Xia M. Liver three-dimensional cellular models for high-throughput chemical testing. Cell Reports Methods 2023;3:100432. [DOI: 10.1016/j.crmeth.2023.100432] [Reference Citation Analysis]
2 Diprospero TJ, Brown LG, Fachko TD, Lockett MR. HepaRG cells undergo increased levels of post-differentiation patterning in physiologic conditions when maintained as 3D cultures in paper-based scaffolds. bioRxiv 2023:2023. [PMID: 36711996 DOI: 10.1101/2023.01.16.524330] [Reference Citation Analysis]
3 Diprospero TJ, Brown LG, Fachko TD, Lockett MR. HepaRG cells undergo increased levels of post-differentiation patterning in physiologic conditions when maintained as 3D cultures in paper-based scaffolds. Res Sq 2023:rs. [PMID: 36711963 DOI: 10.21203/rs.3.rs-2473387/v1] [Reference Citation Analysis]
4 Temple J, Velliou E, Shehata M, Lévy R. Current strategies with implementation of three-dimensional cell culture: the challenge of quantification. Interface Focus 2022;12:20220019. [PMID: 35992772 DOI: 10.1098/rsfs.2022.0019] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 3.0] [Reference Citation Analysis]
5 Mcduffie D, Barr D, Agarwal A, Thomas E. Physiologically relevant microsystems to study viral infection in the human liver. Front Microbiol 2022;13:999366. [DOI: 10.3389/fmicb.2022.999366] [Reference Citation Analysis]
6 Stanley LA, Wolf CR. Through a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism. Drug Metab Rev 2022;:1-17. [PMID: 35188018 DOI: 10.1080/03602532.2022.2039688] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 4.0] [Reference Citation Analysis]
7 Youhanna S, Kemas AM, Preiss L, Zhou Y, Shen JX, Cakal SD, Paqualini FS, Goparaju SK, Shafagh RZ, Lind JU, Sellgren CM, Lauschke VM. Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development-Current State-of-the-Art and Future Perspectives. Pharmacol Rev 2022;74:141-206. [PMID: 35017176 DOI: 10.1124/pharmrev.120.000238] [Cited by in Crossref: 3] [Cited by in F6Publishing: 5] [Article Influence: 3.0] [Reference Citation Analysis]
8 Kammerer S. Three-Dimensional Liver Culture Systems to Maintain Primary Hepatic Properties for Toxicological Analysis In Vitro. Int J Mol Sci 2021;22:10214. [PMID: 34638555 DOI: 10.3390/ijms221910214] [Cited by in Crossref: 10] [Cited by in F6Publishing: 11] [Article Influence: 5.0] [Reference Citation Analysis]
9 Ware BR, Liu JS, Monckton CP, Ballinger KR, Khetani SR. Micropatterned Coculture With 3T3-J2 Fibroblasts Enhances Hepatic Functions and Drug Screening Utility of HepaRG Cells. Toxicol Sci 2021;181:90-104. [PMID: 33590212 DOI: 10.1093/toxsci/kfab018] [Cited by in Crossref: 5] [Cited by in F6Publishing: 6] [Article Influence: 2.5] [Reference Citation Analysis]
10 Abbott A, Coburn JM. HepaRG Maturation in Silk Fibroin Scaffolds: Toward Developing a 3D In Vitro Liver Model. ACS Biomater Sci Eng 2021. [PMID: 34105934 DOI: 10.1021/acsbiomaterials.0c01584] [Cited by in Crossref: 2] [Cited by in F6Publishing: 3] [Article Influence: 1.0] [Reference Citation Analysis]
11 Tomasi RF, Sart S, Champetier T, Baroud CN. Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array. Cell Rep 2020;31:107670. [PMID: 32460010 DOI: 10.1016/j.celrep.2020.107670] [Cited by in Crossref: 36] [Cited by in F6Publishing: 40] [Article Influence: 18.0] [Reference Citation Analysis]
12 Yang Q, Humphreys SC, Lade JM, Li AP. Prolonged cultured human hepatocytes as an in vitro experimental system for the evaluation of potency and duration of activity of RNA therapeutics: Demonstration of prolonged duration of gene silencing effects of a GalNAc-conjugated human hypoxanthine phosphoribosyl transferase (HPRT1) siRNA. Biochem Pharmacol 2021;189:114374. [PMID: 33358826 DOI: 10.1016/j.bcp.2020.114374] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 0.7] [Reference Citation Analysis]
13 Li H, Tang Y, Wang Y, Wei W, Yin C, Tang F. Effects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells. Drug Des Devel Ther 2020;14:5251-8. [PMID: 33273809 DOI: 10.2147/DDDT.S268358] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 0.7] [Reference Citation Analysis]
14 Cox CR, Lynch S, Goldring C, Sharma P. Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver Injury. Front Med Technol 2020;2:611913. [DOI: 10.3389/fmedt.2020.611913] [Cited by in Crossref: 12] [Cited by in F6Publishing: 12] [Article Influence: 4.0] [Reference Citation Analysis]
15 Štampar M, Breznik B, Filipič M, Žegura B. Characterization of In Vitro 3D Cell Model Developed from Human Hepatocellular Carcinoma (HepG2) Cell Line. Cells 2020;9:E2557. [PMID: 33260628 DOI: 10.3390/cells9122557] [Cited by in Crossref: 7] [Cited by in F6Publishing: 8] [Article Influence: 2.3] [Reference Citation Analysis]
16 Kühnl J, Tao TP, Brandmair K, Gerlach S, Rings T, Müller-Vieira U, Przibilla J, Genies C, Jaques-Jamin C, Schepky A, Marx U, Hewitt NJ, Maschmeyer I. Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model. Toxicology 2021;448:152637. [PMID: 33220337 DOI: 10.1016/j.tox.2020.152637] [Cited by in Crossref: 17] [Cited by in F6Publishing: 18] [Article Influence: 5.7] [Reference Citation Analysis]
17 Zhang C, Zhang Q, Li J, Yu L, Li F, Li W, Li Y, Peng H, Zhao J, Carmichael PL, Wang Y, Peng S, Guo J. Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity. Regulatory Toxicology and Pharmacology 2020;114:104661. [DOI: 10.1016/j.yrtph.2020.104661] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 1.7] [Reference Citation Analysis]
18 Sharma VR, Shrivastava A, Gallet B, Karepina E, Charbonnier P, Chevallet M, Jouneau PH, Deniaud A. Canalicular domain structure and function in matrix-free hepatic spheroids. Biomater Sci 2019;8:485-96. [PMID: 31755497 DOI: 10.1039/c9bm01143a] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 1.3] [Reference Citation Analysis]
19 Przekwas A, Somayaji MR. Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems. Organ-on-a-chip 2020. [DOI: 10.1016/b978-0-12-817202-5.00011-5] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 1.3] [Reference Citation Analysis]
20 Zhou Y, Shen JX, Lauschke VM. Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury. Front Pharmacol 2019;10:1093. [PMID: 31616302 DOI: 10.3389/fphar.2019.01093] [Cited by in Crossref: 46] [Cited by in F6Publishing: 48] [Article Influence: 11.5] [Reference Citation Analysis]
21 Elje E, Hesler M, Rundén-pran E, Mann P, Mariussen E, Wagner S, Dusinska M, Kohl Y. The comet assay applied to HepG2 liver spheroids. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2019;845:403033. [DOI: 10.1016/j.mrgentox.2019.03.006] [Cited by in Crossref: 30] [Cited by in F6Publishing: 30] [Article Influence: 7.5] [Reference Citation Analysis]
22 Chong LH, Ng C, Li H, Tian EF, Ananthanarayanan A, McMillian M, Toh YC. Hepatic Bioactivation of Skin-Sensitizing Drugs to Immunogenic Reactive Metabolites. ACS Omega 2019;4:13902-12. [PMID: 31497708 DOI: 10.1021/acsomega.9b01551] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.3] [Reference Citation Analysis]
23 Wang ZY, Li WJ, Li QG, Jing HS, Yuan TJ, Fu GB, Tang D, Zhang HD, Yan HX, Zhai B. A DMSO-free hepatocyte maturation medium accelerates hepatic differentiation of HepaRG cells in vitro. Biomed Pharmacother 2019;116:109010. [PMID: 31136950 DOI: 10.1016/j.biopha.2019.109010] [Cited by in Crossref: 8] [Cited by in F6Publishing: 9] [Article Influence: 2.0] [Reference Citation Analysis]
24 Cox JA, Zwart EP, Luijten M, White PA. The development and prevalidation of an in vitro mutagenicity assay based on MutaMouse primary hepatocytes, Part I: Isolation, structural, genetic, and biochemical characterization. Environ Mol Mutagen 2019;60:331-47. [PMID: 30592088 DOI: 10.1002/em.22253] [Cited by in Crossref: 2] [Cited by in F6Publishing: 3] [Article Influence: 0.4] [Reference Citation Analysis]
25 Ashraf MN, Asghar MW, Rong Y, Doschak MR, Kiang TKL. Advanced In Vitro HepaRG Culture Systems for Xenobiotic Metabolism and Toxicity Characterization. Eur J Drug Metab Pharmacokinet 2019;44:437-58. [DOI: 10.1007/s13318-018-0533-3] [Cited by in Crossref: 10] [Cited by in F6Publishing: 10] [Article Influence: 2.0] [Reference Citation Analysis]
26 Ball AL, Kamalian L, Jolly CE, Chadwick AE. Evaluating Mitotoxicity as Either a Single or Multi-Mechanistic Insult in the Context of Hepatotoxicity. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 2018. [DOI: 10.1002/9781119329725.ch6] [Reference Citation Analysis]
27 Otieno MA, Gan J, Proctor W. Status and Future of 3D Cell Culture in Toxicity Testing. Methods in Pharmacology and Toxicology 2018. [DOI: 10.1007/978-1-4939-7677-5_12] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 0.8] [Reference Citation Analysis]
28 Chong LH, Li H, Wetzel I, Cho H, Toh Y. A liver-immune coculture array for predicting systemic drug-induced skin sensitization. Lab Chip 2018;18:3239-50. [DOI: 10.1039/c8lc00790j] [Cited by in Crossref: 10] [Cited by in F6Publishing: 13] [Article Influence: 2.0] [Reference Citation Analysis]
29 Lee F, Iliescu C, Yu F, Yu H. Constrained spheroids/organoids in perfusion culture. Methods in Cell Biology 2018. [DOI: 10.1016/bs.mcb.2018.05.003] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 1.0] [Reference Citation Analysis]
30 Tevis KM, Colson YL, Grinstaff MW. Embedded Spheroids as Models of the Cancer Microenvironment. Adv Biosyst 2017;1:1700083. [PMID: 30221187 DOI: 10.1002/adbi.201700083] [Cited by in Crossref: 45] [Cited by in F6Publishing: 45] [Article Influence: 7.5] [Reference Citation Analysis]
31 Ong LJY, Chong LH, Jin L, Singh PK, Lee PS, Yu H, Ananthanarayanan A, Leo HL, Toh YC. A pump-free microfluidic 3D perfusion platform for the efficient differentiation of human hepatocyte-like cells. Biotechnol Bioeng 2017;114:2360-70. [PMID: 28542705 DOI: 10.1002/bit.26341] [Cited by in Crossref: 46] [Cited by in F6Publishing: 45] [Article Influence: 7.7] [Reference Citation Analysis]
32 Desai PK, Tseng H, Souza GR. Assembly of Hepatocyte Spheroids Using Magnetic 3D Cell Culture for CYP450 Inhibition/Induction. Int J Mol Sci 2017;18:E1085. [PMID: 28524079 DOI: 10.3390/ijms18051085] [Cited by in Crossref: 32] [Cited by in F6Publishing: 33] [Article Influence: 5.3] [Reference Citation Analysis]
33 Vernetti LA, Vogt A, Gough A, Taylor DL. Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy. Clin Liver Dis 2017;21:197-214. [PMID: 27842772 DOI: 10.1016/j.cld.2016.08.013] [Cited by in Crossref: 27] [Cited by in F6Publishing: 27] [Article Influence: 4.5] [Reference Citation Analysis]
34 Orbach SM, Less RR, Kothari A, Rajagopalan P. In Vitro Intestinal and Liver Models for Toxicity Testing. ACS Biomater Sci Eng 2017;3:1898-910. [PMID: 33440548 DOI: 10.1021/acsbiomaterials.6b00699] [Cited by in Crossref: 16] [Cited by in F6Publishing: 16] [Article Influence: 2.7] [Reference Citation Analysis]
35 Chitrangi S, Nair P, Khanna A. 3D engineered In vitro hepatospheroids for studying drug toxicity and metabolism. Toxicol In Vitro 2017;38:8-18. [PMID: 27794450 DOI: 10.1016/j.tiv.2016.10.009] [Cited by in Crossref: 13] [Cited by in F6Publishing: 14] [Article Influence: 1.9] [Reference Citation Analysis]
36 Gupta N, Liu JR, Patel B, Solomon DE, Vaidya B, Gupta V. Microfluidics-based 3D cell culture models: Utility in novel drug discovery and delivery research. Bioeng Transl Med. 2016;1:63-81. [PMID: 29313007 DOI: 10.1002/btm2.10013] [Cited by in Crossref: 116] [Cited by in F6Publishing: 123] [Article Influence: 16.6] [Reference Citation Analysis]
37 Aleksandrova AV, Burmistrova OA, Fomicheva KA, Sakharov DA. Maintenance of High Cytochrome P450 Expression in HepaRG Cell Spheroids in DMSO-Free Medium. Bull Exp Biol Med 2016;161:120-4. [DOI: 10.1007/s10517-016-3360-z] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 0.6] [Reference Citation Analysis]
38 Gaskell H, Sharma P, Colley HE, Murdoch C, Williams DP, Webb SD. Characterization of a functional C3A liver spheroid model. Toxicol Res (Camb) 2016;5:1053-65. [PMID: 27746894 DOI: 10.1039/c6tx00101g] [Cited by in Crossref: 76] [Cited by in F6Publishing: 78] [Article Influence: 10.9] [Reference Citation Analysis]