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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy  
Justin D Glenn, Katharine A Whartenby 
World J Stem Cells 6(5):526-539. Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.526
2
Common stemness regulators of embryonic and cancer stem cells  
Christiana Hadjimichael, Konstantina Chanoumidou, Natalia Papadopoulou, Panagiota Arampatzi, Joseph Papamatheakis, Androniki Kretsovali 
World J Stem Cells 7(9):1150-1184. Published online Oct 26, 2015. doi: 10.4252/wjsc.v7.i9.1150
3
Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells  
Anna Park, Won Kon Kim, Kwang-Hee Bae 
World J Stem Cells 6(1):33-42. Published online Jan 26, 2014. doi: 10.4252/wjsc.v6.i1.33
4
Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts  
Maya Fakhry, Eva Hamade, Bassam Badran, René Buchet, David Magne 
World J Stem Cells 5(4):136-148. Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.136
5
Current progress in use of adipose derived stem cells in peripheral nerve regeneration  
Shomari DL Zack-Williams, Peter E Butler, Deepak M Kalaskar 
World J Stem Cells 7(1):51-64. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.51
6
Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility  
Tokiko Nagamura-Inoue, Haiping He 
World J Stem Cells 6(2):195-202. Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.195
7
Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse  
Stuart J Emmerson, Caroline E Gargett 
World J Stem Cells 8(5):202-215. Published online May 26, 2016. doi: 10.4252/wjsc.v8.i5.202
8
Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases  
Chie Sugimoto, Hiroyoshi Fujita, Hiroshi Wakao 
World J Stem Cells 8(4):158-169. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.158
9
Augmenting peripheral nerve regeneration using stem cells: A review of current opinion  
Neil G Fairbairn, Amanda M Meppelink, Joanna Ng-Glazier, Mark A Randolph, Jonathan M Winograd 
World J Stem Cells 7(1):11-26. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.11
10
Migration of bone marrow progenitor cells in the adult brain of rats and rabbits  
Donnahue Dennie, Jean-Pierre Louboutin, David S Strayer 
World J Stem Cells 8(4):136-157. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.136
11
Secretion of immunoregulatory cytokines by mesenchymal stem cells  
Dobroslav Kyurkchiev, Ivan Bochev, Ekaterina Ivanova-Todorova, Milena Mourdjeva, Tsvetelina Oreshkova, Kalina Belemezova, Stanimir Kyurkchiev 
World J Stem Cells 6(5):552-570. Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.552
12
Role of Hox genes in stem cell differentiation  
Anne Seifert, David F Werheid, Silvana M Knapp, Edda Tobiasch 
World J Stem Cells 7(3):583-595. Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.583
13
Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance  
John D West, Natalie J Dorà, J Martin Collinson 
World J Stem Cells 7(2):281-299. Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.281
14
Human induced pluripotent stem cells for monogenic disease modelling and therapy  
Paola Spitalieri, Valentina Rosa Talarico, Michela Murdocca, Giuseppe Novelli, Federica Sangiuolo 
World J Stem Cells 8(4):118-135. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.118
15
Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment  
Ying Xiong, Lindsay T McDonald, Dayvia L Russell, Ryan R Kelly, Katie R Wilson, Meenal Mehrotra, Adam C Soloff, Amanda C LaRue 
World J Stem Cells 7(2):253-265. Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.253
16
Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons  
Aaron B Bradford, Patrick M McNutt 
World J Stem Cells 7(6):899-921. Published online Jul 26, 2015. doi: 10.4252/wjsc.v7.i6.899
17
Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells  
Jorge Ribeiro, Tiago Pereira, Ana Rita Caseiro, Paulo Armada-da-Silva, Isabel Pires, Justina Prada, Irina Amorim, Sandra Amado, Miguel França, Carolina Gonçalves, Maria Ascensão Lopes, José Domingos Santos, Dina Morais Silva, Stefano Geuna, Ana Lúcia Luís, Ana Colette Maurício 
World J Stem Cells 7(6):956-975. Published online Jul 26, 2015. doi: 10.4252/wjsc.v7.i6.956
18
Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells  
Amparo Beltran-Povea, Estefania Caballano-Infantes, Carmen Salguero-Aranda, Franz Martín, Bernat Soria, Francisco J Bedoya, Juan R Tejedo, Gladys M Cahuana 
World J Stem Cells 7(3):605-617. Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.605
19
Epidermal stem cells and skin tissue engineering in hair follicle regeneration  
María Eugenia Balañá, Hernán Eduardo Charreau, Gustavo José Leirós 
World J Stem Cells 7(4):711-727. Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.711
20
Human dental pulp stem cells: Applications in future regenerative medicine  
Pravin D Potdar, Yogita D Jethmalani 
World J Stem Cells 7(5):839-851. Published online Jun 26, 2015. doi: 10.4252/wjsc.v7.i5.839
21
Early B lymphocyte development: Similarities and differences in human and mouse  
Michiko Ichii, Kenji Oritani, Yuzuru Kanakura 
World J Stem Cells 6(4):421-431. Published online Sep 26, 2014. doi: 10.4252/wjsc.v6.i4.421
22
Intestinal stem cells and celiac disease  
Anna Chiara Piscaglia 
World J Stem Cells 6(2):213-229. Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.213
23
Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy?  
Ann De Becker, Ivan Van Riet 
World J Stem Cells 8(3):73-87. Published online Mar 26, 2016. doi: 10.4252/wjsc.v8.i3.73
24
Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics  
Antonio Garcia-Gomez, Fermin Sanchez-Guijo, M Consuelo del Cañizo, Jesus F San Miguel, Mercedes Garayoa 
World J Stem Cells 6(3):322-343. Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.322
25
Use of bone morphogenetic proteins in mesenchymal stem cell stimulation of cartilage and bone repair  
Sonia Scarfì 
World J Stem Cells 8(1):1-12. Published online Jan 26, 2016. doi: 10.4252/wjsc.v8.i1.1
26
Cell signalling pathways underlying induced pluripotent stem cell reprogramming  
Kate Hawkins, Shona Joy, Tristan McKay 
World J Stem Cells 6(5):620-628. Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.620
27
Cancer stem cell plasticity and tumor hierarchy  
Marina Carla Cabrera, Robert E Hollingsworth, Elaine M Hurt 
World J Stem Cells 7(1):27-36. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.27
28
Adoptive immunotherapy for acute leukemia: New insights in chimeric antigen receptors  
Maël Heiblig, Mohamed Elhamri, Mauricette Michallet, Xavier Thomas 
World J Stem Cells 7(7):1022-1038. Published online Aug 26, 2015. doi: 10.4252/wjsc.v7.i7.1022
29
Generation of diverse neural cell types through direct conversion  
Gayle F Petersen, Padraig M Strappe 
World J Stem Cells 8(2):32-46. Published online Feb 26, 2016. doi: 10.4252/wjsc.v8.i2.32
30
Emerging role of microRNAs in cancer stem cells: Implications in cancer therapy  
Minal Garg 
World J Stem Cells 7(8):1078-1089. Published online Sep 26, 2015. doi: 10.4252/wjsc.v7.i8.1078
31
Dedifferentiated fat cells: A cell source for regenerative medicine  
Medet Jumabay, Kristina I Boström 
World J Stem Cells 7(10):1202-1214. Published online Nov 26, 2015. doi: 10.4252/wjsc.v7.i10.1202
32
Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells  
Estefania Caballano-Infantes, José Terron-Bautista, Amparo Beltrán-Povea, Gladys M Cahuana, Bernat Soria, Hajji Nabil, Francisco J Bedoya, Juan R Tejedo 
World J Stem Cells 9(2):26-36. Published online Feb 26, 2017. doi: 10.4252/wjsc.v9.i2.26
33
Next-generation sequencing traces human induced pluripotent stem cell lines clonally generated from heterogeneous cancer tissue  
Tetsuya Ishikawa 
World J Stem Cells 9(5):77-88. Published online May 26, 2017. doi: 10.4252/wjsc.v9.i5.77
34
Simplified three-dimensional culture system for long-term expansion of embryonic stem cells  
Christina McKee, Mick Perez-Cruet, Ferman Chavez, G Rasul Chaudhry 
World J Stem Cells 7(7):1064-1077. Published online Aug 26, 2015. doi: 10.4252/wjsc.v7.i7.1064
35
Insights into kidney stem cell development and regeneration using zebrafish  
Bridgette E Drummond, Rebecca A Wingert 
World J Stem Cells 8(2):22-31. Published online Feb 26, 2016. doi: 10.4252/wjsc.v8.i2.22
36
Renal progenitors: Roles in kidney disease and regeneration  
Brooke E Chambers, Rebecca A Wingert 
World J Stem Cells 8(11):367-375. Published online Nov 26, 2016. doi: 10.4252/wjsc.v8.i11.367
37
Mesenchymal stem cells help pancreatic islet transplantation to control type 1 diabetes  
Marina Figliuzzi, Barbara Bonandrini, Sara Silvani, Andrea Remuzzi 
World J Stem Cells 6(2):163-172. Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.163
38
Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease  
Etsu Suzuki, Daishi Fujita, Masao Takahashi, Shigeyoshi Oba, Hiroaki Nishimatsu 
World J Stem Cells 8(9):297-305. Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.297
39
Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy  
Jorge Zorzopulos, Steven M Opal, Andrés Hernando-Insúa, Juan M Rodriguez, Fernanda Elías, Juan Fló, Ricardo A López, Norma A Chasseing, Victoria A Lux-Lantos, Maria F Coronel, Raul Franco, Alejandro D Montaner, David L Horn 
World J Stem Cells 9(3):45-67. Published online Mar 26, 2017. doi: 10.4252/wjsc.v9.i3.45
40
41
Immunomodulation by mesenchymal stem cells: Interplay between mesenchymal stem cells and regulatory lymphocytes  
Oscar Ka-Fai Ma, Koon Ho Chan 
World J Stem Cells 8(9):268-278. Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.268
42
MicroRNAs as novel regulators of stem cell fate  
Eunhyun Choi, Eunmi Choi, Ki-Chul Hwang 
World J Stem Cells 5(4):172-187. Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.172
43
44
Complement activation in the context of stem cells and tissue repair  
Ingrid U Schraufstatter, Sophia K Khaldoyanidi, Richard G DiScipio 
World J Stem Cells 7(8):1090-1108. Published online Sep 26, 2015. doi: 10.4252/wjsc.v7.i8.1090
45
Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives  
Benoîte Méry, Jean-Baptiste Guy, Sophie Espenel, Anne-Sophie Wozny, Stéphanie Simonet, Alexis Vallard, Gersende Alphonse, Dominique Ardail, Claire Rodriguez-Lafrasse, Nicolas Magné 
World J Stem Cells 8(1):13-21. Published online Jan 26, 2016. doi: 10.4252/wjsc.v8.i1.13
46
Allogenic banking of dental pulp stem cells for innovative therapeutics  
Pierre-Yves Collart-Dutilleul, Franck Chaubron, John De Vos, Frédéric J Cuisinier 
World J Stem Cells 7(7):1010-1021. Published online Aug 26, 2015. doi: 10.4252/wjsc.v7.i7.1010
47
Epithelial-mesenchymal transition - activating transcription factors - multifunctional regulators in cancer  
Minal Garg 
World J Stem Cells 5(4):188-195. Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.188
48
Neural differentiation from embryonic stem cells in vitro: An overview of the signaling pathways  
Jen-Hua Chuang, Li-Chu Tung, Yenshou Lin 
World J Stem Cells 7(2):437-447. Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.437
49
Skeletal muscle generated from induced pluripotent stem cells - induction and application  
Yuko Miyagoe-Suzuki, Shin’ichi Takeda 
World J Stem Cells 9(6):89-97. Published online Jun 26, 2017. doi: 10.4252/wjsc.v9.i6.89
50
Therapies targeting cancer stem cells: Current trends and future challenges  
Denisa L Dragu, Laura G Necula, Coralia Bleotu, Carmen C Diaconu, Mihaela Chivu-Economescu 
World J Stem Cells 7(9):1185-1201. Published online Oct 26, 2015. doi: 10.4252/wjsc.v7.i9.1185