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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling  
Nipha Chaicharoenaudomrung, Phongsakorn Kunhorm, Parinya Noisa 
World J Stem Cells 11(12):1065-1083. Published online Dec 26, 2019. doi: 10.4252/wjsc.v11.i12.1065
2
Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy  
Justin D Glenn, Katharine A Whartenby 
World J Stem Cells 6(5):526-539. Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.526
3
Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases  
Chie Sugimoto, Hiroyoshi Fujita, Hiroshi Wakao 
World J Stem Cells 8(4):158-169. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.158
4
Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells  
Anna Park, Won Kon Kim, Kwang-Hee Bae 
World J Stem Cells 6(1):33-42. Published online Jan 26, 2014. doi: 10.4252/wjsc.v6.i1.33
5
Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts  
Maya Fakhry, Eva Hamade, Bassam Badran, René Buchet, David Magne 
World J Stem Cells 5(4):136-148. Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.136
6
Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment  
Antonin Bukovsky 
World J Stem Cells 8(12):399-427. Published online Dec 26, 2016. doi: 10.4252/wjsc.v8.i12.399
7
Secretion of immunoregulatory cytokines by mesenchymal stem cells  
Dobroslav Kyurkchiev, Ivan Bochev, Ekaterina Ivanova-Todorova, Milena Mourdjeva, Tsvetelina Oreshkova, Kalina Belemezova, Stanimir Kyurkchiev 
World J Stem Cells 6(5):552-570. Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.552
8
Common stemness regulators of embryonic and cancer stem cells  
Christiana Hadjimichael, Konstantina Chanoumidou, Natalia Papadopoulou, Panagiota Arampatzi, Joseph Papamatheakis, Androniki Kretsovali 
World J Stem Cells 7(9):1150-1184. Published online Oct 26, 2015. doi: 10.4252/wjsc.v7.i9.1150
9
Epidermal stem cells and skin tissue engineering in hair follicle regeneration  
María Eugenia Balañá, Hernán Eduardo Charreau, Gustavo José Leirós 
World J Stem Cells 7(4):711-727. Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.711
10
Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility  
Tokiko Nagamura-Inoue, Haiping He 
World J Stem Cells 6(2):195-202. Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.195
11
Current progress in use of adipose derived stem cells in peripheral nerve regeneration  
Shomari DL Zack-Williams, Peter E Butler, Deepak M Kalaskar 
World J Stem Cells 7(1):51-64. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.51
12
Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse  
Stuart J Emmerson, Caroline E Gargett 
World J Stem Cells 8(5):202-215. Published online May 26, 2016. doi: 10.4252/wjsc.v8.i5.202
13
Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy?  
Ann De Becker, Ivan Van Riet 
World J Stem Cells 8(3):73-87. Published online Mar 26, 2016. doi: 10.4252/wjsc.v8.i3.73
14
Augmenting peripheral nerve regeneration using stem cells: A review of current opinion  
Neil G Fairbairn, Amanda M Meppelink, Joanna Ng-Glazier, Mark A Randolph, Jonathan M Winograd 
World J Stem Cells 7(1):11-26. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.11
15
Role of Hox genes in stem cell differentiation  
Anne Seifert, David F Werheid, Silvana M Knapp, Edda Tobiasch 
World J Stem Cells 7(3):583-595. Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.583
16
Human induced pluripotent stem cells for monogenic disease modelling and therapy  
Paola Spitalieri, Valentina Rosa Talarico, Michela Murdocca, Giuseppe Novelli, Federica Sangiuolo 
World J Stem Cells 8(4):118-135. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.118
17
Migration of bone marrow progenitor cells in the adult brain of rats and rabbits  
Donnahue Dennie, Jean-Pierre Louboutin, David S Strayer 
World J Stem Cells 8(4):136-157. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.136
18
Cancer stem cell impact on clinical oncology  
Mariel E Toledo-Guzmán, Gabriele D Bigoni-Ordóñez, Miguel Ibáñez Hernández, Elizabeth Ortiz-Sánchez 
World J Stem Cells 10(12):183-195. Published online Dec 26, 2018. doi: 10.4252/wjsc.v10.i12.183
19
Human dental pulp stem cells: Applications in future regenerative medicine  
Pravin D Potdar, Yogita D Jethmalani 
World J Stem Cells 7(5):839-851. Published online Jun 26, 2015. doi: 10.4252/wjsc.v7.i5.839
20
Rat model of anal sphincter injury and two approaches for stem cell administration  
Jacobo Trébol, Tihomir Georgiev-Hristov, Luz Vega-Clemente, Ignacio García-Gómez, Ana Carabias-Orgaz, Mariano García-Arranz, Damián García-Olmo 
World J Stem Cells 10(1):1-14. Published online Jan 26, 2018. doi: 10.4252/wjsc.v10.i1.1
21
Immunomodulatory oligonucleotide IMT504: Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy  
Jorge Zorzopulos, Steven M Opal, Andrés Hernando-Insúa, Juan M Rodriguez, Fernanda Elías, Juan Fló, Ricardo A López, Norma A Chasseing, Victoria A Lux-Lantos, Maria F Coronel, Raul Franco, Alejandro D Montaner, David L Horn 
World J Stem Cells 9(3):45-67. Published online Mar 26, 2017. doi: 10.4252/wjsc.v9.i3.45
22
Next-generation sequencing traces human induced pluripotent stem cell lines clonally generated from heterogeneous cancer tissue  
Tetsuya Ishikawa 
World J Stem Cells 9(5):77-88. Published online May 26, 2017. doi: 10.4252/wjsc.v9.i5.77
23
Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis in vitro and in vivo: From biological characteristics to therapeutic mechanisms  
Fei Yin, Wen-Ying Wang, Wen-Hua Jiang 
World J Stem Cells 11(8):548-564. Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.548
24
Long non-coding RNA: The functional regulator of mesenchymal stem cells  
Zhong-Yu Xie, Peng Wang, Yan-Feng Wu, Hui-Yong Shen 
World J Stem Cells 11(3):167-179. Published online Mar 26, 2019. doi: 10.4252/wjsc.v11.i3.167
25
Issues and opportunities of stem cell therapy in autoimmune diseases  
Györgyi Műzes, Ferenc Sipos 
World J Stem Cells 11(4):212-221. Published online Apr 26, 2019. doi: 10.4252/wjsc.v11.i4.212
26
Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: A concise review  
Ai-Tong Wang, Ying Feng, Hong-Hong Jia, Meng Zhao, Hao Yu 
World J Stem Cells 11(4):222-235. Published online Apr 26, 2019. doi: 10.4252/wjsc.v11.i4.222
27
Early B lymphocyte development: Similarities and differences in human and mouse  
Michiko Ichii, Kenji Oritani, Yuzuru Kanakura 
World J Stem Cells 6(4):421-431. Published online Sep 26, 2014. doi: 10.4252/wjsc.v6.i4.421
28
Immunomodulation by mesenchymal stem cells: Interplay between mesenchymal stem cells and regulatory lymphocytes  
Oscar Ka-Fai Ma, Koon Ho Chan 
World J Stem Cells 8(9):268-278. Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.268
29
Adipose-derived stromal/stem cells from different adipose depots in obesity development  
Karina Ribeiro Silva, Leandra Santos Baptista 
World J Stem Cells 11(3):147-166. Published online Mar 26, 2019. doi: 10.4252/wjsc.v11.i3.147
30
Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment  
Ying Xiong, Lindsay T McDonald, Dayvia L Russell, Ryan R Kelly, Katie R Wilson, Meenal Mehrotra, Adam C Soloff, Amanda C LaRue 
World J Stem Cells 7(2):253-265. Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.253
31
Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons  
Aaron B Bradford, Patrick M McNutt 
World J Stem Cells 7(6):899-921. Published online Jul 26, 2015. doi: 10.4252/wjsc.v7.i6.899
32
Cancer stem cell plasticity and tumor hierarchy  
Marina Carla Cabrera, Robert E Hollingsworth, Elaine M Hurt 
World J Stem Cells 7(1):27-36. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.27
33
Stromal cell-derived factor-1α promotes recruitment and differentiation of nucleus pulposus-derived stem cells  
Jin-Wei Ying, Tian-Yong Wen, Shi-Shen Pei, Ling-Hao Su, Di-Ke Ruan 
World J Stem Cells 11(3):196-211. Published online Mar 26, 2019. doi: 10.4252/wjsc.v11.i3.196
34
Tracing and targeting cancer stem cells: New venture for personalized molecular cancer therapy  
Ramin Radpour 
World J Stem Cells 9(10):169-178. Published online Oct 26, 2017. doi: 10.4252/wjsc.v9.i10.169
35
Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders  
Qiang Liu, Mo-Xian Chen, Lin Sun, Chloe U Wallis, Jian-Song Zhou, Li-Juan Ao, Qi Li, Pak C Sham 
World J Stem Cells 11(2):55-72. Published online Feb 26, 2019. doi: 10.4252/wjsc.v11.i2.55
36
Targeting cancer stem cells in drug discovery: Current state and future perspectives  
Fang-Yu Du, Qi-Fan Zhou, Wen-Jiao Sun, Guo-Liang Chen 
World J Stem Cells 11(7):398-420. Published online Jul 26, 2019. doi: 10.4252/wjsc.v11.i7.398
37
Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance  
John D West, Natalie J Dorà, J Martin Collinson 
World J Stem Cells 7(2):281-299. Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.281
38
Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytes  
Pranav Machiraju, Steven C Greenway 
World J Stem Cells 11(1):33-43. Published online Jan 26, 2019. doi: 10.4252/wjsc.v11.i1.33
39
Renal progenitors: Roles in kidney disease and regeneration  
Brooke E Chambers, Rebecca A Wingert 
World J Stem Cells 8(11):367-375. Published online Nov 26, 2016. doi: 10.4252/wjsc.v8.i11.367
40
Use of bone morphogenetic proteins in mesenchymal stem cell stimulation of cartilage and bone repair  
Sonia Scarfì 
World J Stem Cells 8(1):1-12. Published online Jan 26, 2016. doi: 10.4252/wjsc.v8.i1.1
41
Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells  
Estefania Caballano-Infantes, José Terron-Bautista, Amparo Beltrán-Povea, Gladys M Cahuana, Bernat Soria, Hajji Nabil, Francisco J Bedoya, Juan R Tejedo 
World J Stem Cells 9(2):26-36. Published online Feb 26, 2017. doi: 10.4252/wjsc.v9.i2.26
42
Sox2, a key factor in the regulation of pluripotency and neural differentiation  
Shuchen Zhang, Wei Cui 
World J Stem Cells 6(3):305-311. Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.305
43
Generation of diverse neural cell types through direct conversion  
Gayle F Petersen, Padraig M Strappe 
World J Stem Cells 8(2):32-46. Published online Feb 26, 2016. doi: 10.4252/wjsc.v8.i2.32
44
Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease  
Etsu Suzuki, Daishi Fujita, Masao Takahashi, Shigeyoshi Oba, Hiroaki Nishimatsu 
World J Stem Cells 8(9):297-305. Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.297
45
Functional and molecular mechanism of intracellular pH regulation in human inducible pluripotent stem cells  
Shih-Chi Chao, Gwo-Jang Wu, Shu-Fu Huang, Niann-Tzyy Dai, Hsu-Kai Huang, Mei-Fang Chou, Yi-Ting Tsai, Shiao-Pieng Lee, Shih-Hurng Loh 
World J Stem Cells 10(12):196-211. Published online Dec 26, 2018. doi: 10.4252/wjsc.v10.i12.196
46
Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics  
Antonio Garcia-Gomez, Fermin Sanchez-Guijo, M Consuelo del Cañizo, Jesus F San Miguel, Mercedes Garayoa 
World J Stem Cells 6(3):322-343. Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.322
47
Regenerative potential of mouse embryonic stem cell-derived PDGFRα+ cardiac lineage committed cells in infarcted myocardium  
Seon Pyo Hong, Sukhyun Song, Seungjoo Lee, Hyeonju Jo, Hyoung Kyu Kim, Jin Han, Jae-Hyeong Park, Sung Woo Cho 
World J Stem Cells 11(1):44-54. Published online Jan 26, 2019. doi: 10.4252/wjsc.v11.i1.44
48
Insights into kidney stem cell development and regeneration using zebrafish  
Bridgette E Drummond, Rebecca A Wingert 
World J Stem Cells 8(2):22-31. Published online Feb 26, 2016. doi: 10.4252/wjsc.v8.i2.22
49
Skeletal muscle generated from induced pluripotent stem cells - induction and application  
Yuko Miyagoe-Suzuki, Shin’ichi Takeda 
World J Stem Cells 9(6):89-97. Published online Jun 26, 2017. doi: 10.4252/wjsc.v9.i6.89
50
Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells  
Jorge Ribeiro, Tiago Pereira, Ana Rita Caseiro, Paulo Armada-da-Silva, Isabel Pires, Justina Prada, Irina Amorim, Sandra Amado, Miguel França, Carolina Gonçalves, Maria Ascensão Lopes, José Domingos Santos, Dina Morais Silva, Stefano Geuna, Ana Lúcia Luís, Ana Colette Maurício 
World J Stem Cells 7(6):956-975. Published online Jul 26, 2015. doi: 10.4252/wjsc.v7.i6.956