Copyright ©The Author(s) 2020.
World J Stem Cells. Aug 26, 2020; 12(8): 814-840
Published online Aug 26, 2020. doi: 10.4252/wjsc.v12.i8.814
Table 1 Characteristics of different types of extracellular vesicles
FeatureExosomesMicrovesiclesApoptotic bodies
Diameter and shape30-100 nm, cup shape100-1000 nm, irregular shape1-5 μm, heterogeneous shape
Sucrose gradient1.13-1.19 g/mL1.04-1.07 g/mL1.18-1.28 g/mL
Sedimentation100000 g10000 g16000 g
Protein markersCD63, CD81, CD9, Alix, Tsg101, annexins, heat-shock proteinsIntegrins, selectins, CD40, flotillins, CD40, ARF6, VCAMP3TSP, C3b, histones
OriginFusion of multivesicular bodies with cell membraneOutward budding of cell membraneOutward budding of apoptotic cell membrane
Lipid contentCeramidePhosphatidylserinePhosphatidylserine
Nucleic acidsDNA, mRNA, miRNA, non-coding RNADNA, mRNA, miRNA, non-coding RNAFragmented DNA, mRNA, miRNA, non-coding RNA