Copyright ©The Author(s) 2019.
World J Stem Cells. Aug 26, 2019; 11(8): 548-564
Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.548
Table 1 Clinical trials in liver diseases using human umbilical cord mesenchymal stem cells
Ref.Administration routeNumber of cells infusedEtiology or diseaseStudy design, n for total; groupsFollow-up periodTrial numberResults
[110]Intravenous(4.0-4.5) × 108Decompensated liver cirrhosis103; 50 hUC-MSCs, 53 control52 wkChiCTR-ONC-12002103Decrease in AST, increase in ALB, TBIL, PT Improvement in MELD and Child-Pugh scores
[56]Intravenous0.5 × 106/kg Every 4 wk, 3 timesACLF (HBV cirrhosis)43; 24 hUC-MSCs, 19 control72 wkNCT01218464Improvement in MELD Increase in ALB, PT
[111]Intravenous0.5 × 106/kg Every 4 wk, 3 timesCirrhosis (HBV)45; 30 hUC-MSCs, 15 control48 wkNCT01220492Decrease in ascites. Increase in ALB, TBIL. Improvement in MELD.
[112]Intravenous0.5 × 106/kg Every 4 wk, 3 timesUDCA-resistant PBC748 wkNCT01662973Decrease in ALP, γ-GT, fatigue, pruritus Improvement quality of life
[113]Intravenous1 × 106/kg; wk 1, 2, 4, 8, 12 and 16Ischemic-type biliary lesions82; 12 hUC-MSCs, 70 control96 wkNCT02223897Decrease in BIL, ALP, γ-GT Improvement in graft survival
[114]Intravenous1 × 106/kg; Every 4 wk, 3 timesLiver transplant patients with acute graft rejection27; 14 hUC-MSCs, 13 control12 wkNCT01690247Decrease in ALT, AST, TBIL, acute rejection Improvement in liver allograft histology
Peripheral vein4.0 × 107/patient, 4 timesLC320144 wkNCT01573923Unknown
UnknownUnknownLC2048 wkNCT01342250Unknown
Peripheral vein1.0 × 105/kg, 4 timesLiver failure (HBV)12048 wkNCT01724398Unknown
Portal vein or hepatic arteryUnknownLC20048 wkNCT01233102Unknown
Hepatic arteryUnknownLC504 wkNCT01224327Unknown
Hepatic artery1.0 × 106/kgLC (HBV)24048 wkNCT01728727Unknown
Peripheral vein21072 wkNCT01844063Unknown
Peripheral veinUnknownACLF (HBV)26152 wkNCT02812121Unknown
Portal vein or hepatic artery2.0 × 107/patient, 4 timesLC2048 wkNCT02652351Unknown
Peripheral vein1.0 × 106/kg, 3 timesLiver failure (AIH)10096 wkNCT01661842Unknown
Lobe5.0 × 108/patientLC4096 wkNCT02786017Unknown