Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.776
Revised: February 5, 2015
Accepted: March 5, 2015
Published online: May 26, 2015
Core tip: This study provides novel data on the therapeutic effect of culture expanded fetal kidney stem cells (fKSC) in acute renal failure (ARF). The fKSC represent primitive renal stem cells that express mesenchymal and renal progenitor markers. They exhibit in vitro angiogenesis and potential to differentiate into renal epithelial cells. On administration in ARF rats, they rapidly improve renal function and histology. The therapeutic effects of fKSC are accompanied with increased capillary density in kidney tissues suggesting that induction of renal angiogenesis may be an important therapeutic mechanism of these stem cells.