临床经验
Copyright ©The Author(s) 2014.
世界华人消化杂志. 2014-01-28; 22(3): 415-422
在线出版 2014-01-28. doi: 10.11569/wcjd.v22.i3.415
表1 25种血浆miRNA实时荧光定量PCR检测结果
No.miRNA name△△Ct2-△△CtRegulation
1hsa-miR-4284-1.93.66Up
2hsa-miR-3620-1.63.09Up
3hsa-miR-652-5p-1.32.50Up
4hsa-miR-4800-5p-1.12.08Up
5hsa-miR-1249-0.91.92N
6hsa-miR-3937-0.91.85N
7hsa-miR-584-5p-0.81.77N
8hsa-miR-1226-5p-0.81.75N
9hsa-miR-4298-0.81.69N
10hsa-miR-4655-3p-0.61.57N
11hsa-miR-1260a-0.61.50N
12hsa-miR-1224-5p-0.61.48N
13hsa-miR-577-0.41.29N
14hsa-miR-378i-0.21.14N
15hsa-miR-663a0.01.03N
16hsa-miR-42860.10.92N
17hsa-miR-7-5p0.40.75N
18hsa-miR-34a-5p0.60.66N
19hsa-miR-454-3p0.60.65N
20hsa-miR-125b-5p0.70.63N
21hsa-miR-32-5p0.70.62N
22hsa-miR-144-5p0.70.61N
23hsa-miR-338-3p1.10.48Down
24hsa-miR-424-5p1.10.47Down
25hsa-miR-194-5p1.30.39Down
表2 部分miRNA靶基因及其GO生物学功能
序号miRNA积分靶基因基因全称GO生物学功能
1hsa-miR-4800-5p100ITGB1BP1integrin beta 1 binding protein 1整合素结合蛋白, 细胞黏附功能
2hsa-miR-428499GNG13guanine nucleotide binding protein (G protein), gamma 13水解酶; G蛋白耦联受体蛋白
3hsa-miR-428498VPS53vacuolar protein sorting 53 homolog (S. cerevisiae)线粒体内膜蛋白, 参与脂质代谢过程
4hsa-miR-428498MAVSmitochondrial antiviral signaling protein线粒体信号蛋白
5hsa-miR-428497ORAI2ORAI calcium release-activated calcium modulator 2钙释放激活钙调素
6hsa-miR-652-5p94SEC14L1SEC14-like 1 (S. cerevisiae)胆固醇代谢转运/携带蛋白
7hsa-miR-428493SPNsialophorin炎细胞表面糖蛋白, 负调控免疫应答
8hsa-miR-428491LOC100653346uncharacterized LOC100653346功能不清
9hsa-miR-428491TMEM120Btransmembrane protein 120B物质代谢过程
10hsa-miR-428490CYP20A1cytochrome P450, family 20, subfamily A, polypeptide 1氧化酶
11hsa-miR-428489OPA3optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)线粒体外膜蛋白
12hsa-miR-428489CDK17cyclin-dependent kinase 17非受体丝/苏氨酸蛋白激酶
13hsa-miR-428489RAB3BRAB3B, member RAS oncogene family小分子GTP结合蛋白, RAB家族成员
14hsa-miR-652-5p88SLC25A24solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24线粒体携带因子
15hsa-miR-428488PLA2R1phospholipase A2 receptor 1, 180 kDa磷酯酶A2受体
16hsa-miR-362088USP46ubiquitin specific peptidase 46丝氨酸蛋白酶; 泛素-蛋白质连接酶
17hsa-miR-362087PUM1pumilio homolog 1 (Drosophila)翻译因子
18hsa-miR-4800-5p87DTLdenticleless homolog (Drosophila)核基质相关蛋白
19hsa-miR-428486ZNF292zinc finger protein 292核酸酶; 转录因子
20hsa-miR-428486PLIN5perilipin 5脂质转运/携带蛋白
21hsa-miR-428486ENAHEnabled homolog (Drosophila)细胞骨架结构成份
22hsa-miR-428485RAB3IPRAB3A interacting protein (rabin3)鸟苷酸交换因子; 信号转导
23hsa-miR-362085ACPPacid phosphatase, prostate磷酯酶
24hsa-miR-652-5p83TLR7toll-like receptor 7Toll受体信号通路
25hsa-miR-652-5p83RRAS2related RAS viral (r-ras) oncogene homolog 2小GTP酶
26hsa-miR-362083GPBP1L1GC-rich promoter binding protein 1-like 1功能不清
27hsa-miR-428482RLIMring finger protein, LIM domain interactingE3泛素蛋白连接酶, 可调控细胞迁移
28hsa-miR-362082INSIG2insulin induced gene 2胆固醇代谢过程
29hsa-miR-428482ZFR2zinc finger RNA binding protein 2RNA结合蛋白
30hsa-miR-652-5p81UTS2Durotensin 2 domain containing功能不清
31hsa-miR-652-5p81PRKCAprotein kinase C, alpha非受体丝/苏氨酸蛋白激酶
32hsa-miR-362081TSPAN9tetraspanin 9膜结合信号分子; 受体; 细胞黏附分子
33hsa-miR-428480AAK1AP2 associated kinase 1非受体丝/苏氨酸蛋白激酶

引文著录: 叶长根, 孙水林, 白茹, 朱伟星, 陈彩萍, 谢平, 赵晖, 涂文娟, 高得勇, 刘亮明. 抗结核药物肝损伤与无肝损伤患者化疗前血循环miRNA分子的差异性表达. 世界华人消化杂志 2014; 22(3): 415-422