非人灵长类动物急性肝功能衰竭模型的建立

表1 各组实验猴的生化指标及Â内压的变化 (mean±SD)

分组	ALT(U/L)	TBIL(mmol/L)	PT(s)	NH3(g/dL)	ICP(mmHg)
高剂量组
0 h	32.68±2.35	0.85±0.17	9.63±0.32	33.60±2.71	7.94±0.65
12 h	200.80±22.61	1.81±0.24	13.20±1.75	81.58±5.39	10.96±0.56
24 h	608.40±39.75	13.60±1.60	34.24±3.28	102.04±6.48	12.00±0.37
36 h	787.40±47.47	19.80±1.01	55.90±5.19	132.56±8.47	12.98±0.49
48 h	1 026.60±84.78	27.74±2.34	84.28±5.47	196.80±9.26	19.40±1.34
60 h
72 h
96 h
中剂量组
0 h	32.00±2.55	0.88±0.15	9.30±0.24	31.68±2.47	7.80±0.39
12 h	150.00±9.19a	1.64±0.29	13.12±0.96	51.36±2.59a	10.14±0.71a
24 h	377.20±34.33a	11.53±1.35	27.00±2.08a	70.82±3.46a	10.40±0.52a
36 h	338.60±24.12a	14.22±0.70a	41.16±3.20a	98.02±6.77a	11.94±0.74a
48 h	493.60±46.49a	18.24±1.39a	63.96±4.69a	161.60±11.68a	14.06±1.02a
60 h	710.60±29.18	59.80±2.26	109.38±8.90	201.98±9.86	19.58±1.09a
72 h	907.20±42.46	85.36±4.04	139.96±11.58	261.98±9.86
96 h	1 032.00±92.41	115.86±6.84		296.12±18.17
低剂量组
0 h	31.20±2.59	0.97±0.20	9.52±0.36	31.32±1.99	7.48±0.40
12 h	100.40±22.64ac	1.46±0.28	10.22±0.66ac	32.66±3.00a	7.88±0.40a
24 h	152.00±17.45ac	11.30±0.79a	20.90±1.60ac	36.92±4.11ac	8.02±0.18a
36 h	221.00±23.32ac	12.40±1.60a	32.88±2.92ac	57.24±3.20ac	8.32±0.44ac
48 h	331.00±36.33ac	16.92±1.02a	51.00±2.85ac	79.70±3.19ac	10.22±0.70ac
60 h	409.00±27.95c	34.54±1.73c	61.48±6.22c	100.66±6.69c	10.16±0.69c
72 h	336.60±50.92c	21.44±1.44c	64.18±5.40c	87.66±4.79c
96 h	206.60±41.64c	18.84±0.94c	65.56±4.03c

^aP<0.05 vs 高剂量组同时点;

^cP<0.05 vs 中剂量组同时点.