肝癌发生过程中的差异基因表达

表1 在肝炎、肝硬化、肝癌中共同上调表达的基因

编号	Gene代码	基因描述	染色体定位		比值
1	Hs.534362	Protease, serine, 1(trypsin 1), PRSS1	7q34		181.02
2	Hs.9029	Keratin 23(histone deacetylase inducible), KRT23	17q21.2		51.98
3	Hs.20415	Family with sequence similarity 3, member B, FAM3B	21q22.3		42.22
4	Hs.313	Secreted phosphoprotein 1, SPP1	4q21-q25		39.40
5	Hs.80962	Neurotensin, NTS	12q21		24.25
6	Hs.5940	Mucin 13, epithelial transmembrane, MUC13	3q13.3		22.63
7	Hs.108106	Ubiquitin-like, containing PHD and RING finger domains 1, UHRF1	19p13.3		22.63
8	Hs.165636	DIRAS family, GTP-binding RAS-like 2, DIRAS2	9q22.2		18.38
9	Hs.692	Tumor-associated calcium signal transducer 1,TACSTD1	2p21		16.00
10	Hs.121017	Histone 1, H2ae, HIST1H2AE	6p22.2-p21.1		16.00
11	Hs.237396	Hypothetical protein LOC643911, LOC643911	16q12.2		34.00
12	Hs.296341	CAP, adenylate cyclase-associated protein, 2 (yeast), CAP2	6p22.3		16.00
13	Hs.375108	CD24 antigen(small cell lung carcinoma cluster 4 antigen), CD24	6q21		14.93
14	Hs.421956	Spindle pole body component 25 homolog, Spc25	2q24.3		14.93
15	Hs.414467	Homeo box A13, HOXA13	7p15-p14		14.93
16	Hs.132748	Ribosomal protein L39-like, RPL39L	3q27		14.93
17	Hs.352662	Golgi phosphoprotein 2, GOLPH2	9q21.33		13.93
18	Hs.528669	Chromosome condensation protein G, HCAP-G	4p15.33		10.20
19	Hs.431270	Chromosome 9 open reading frame 125, C9orf125	9q31.1		9.19
20	Hs.458287	N-acetyltransferase 8B, NAT8B	2p13.1		8.57
21	Hs.436170	Nudix(nucleoside diphosphate linked moiety X)type motif 14, NUDT14	14q32.33		8.00
22	Hs.65436	Lysyl oxidase-like 1, LOXL1	15q22		6.96
23	Hs.228320	Chromosome 10 open reading frame 81, C10orf81	10q25.3		6.73
24	Hs.182137	Histone 1, H2bg, HIST1H2BG	6p21.3		6.73
25	Hs.82302	Heparan sulfate 6-O-sulfotransferase 2, HS6ST2	xq26.2		6.65
26	Hs.132526	Melanoma antigen, LOC51152	1q21.1		6.50
27	Hs.2316	SRY (sex determining region Y)-box 9, SOX9	17q24.3-q25.1	6.28
28	Hs.166071	Cyclin-dependent kinase 5, CDK5	7q36		6.06
29	Hs.169300	Transforming growth factor, beta 2, TGFB2	1q41		5.86
30	Hs.444118	MCM6 minichromosome maintenance deficient 6 , MCM6	2q21		5.10
31	Hs.44532	Ubiquitin D, UBD	6p21.3		4.92
32	Hs.105859	Hypothetical protein FLJ10260, FLJ10260	17q12		4.59
33	Hs.14968	Pleiomorphic adenoma gene 1, PLAG1	8q12		4.59
34	Hs.352213	Hypothetical protein LOC131368, LOC131368	3q12.3		4.29
35	Hs.445489	Pleckstrin homology domain containing, family B member 1, PLEKHB1	11q13.5-q14.1	4.29
36	Hs.48554	RAP2A, member of RAS oncogene family, RAP2A	13q34		3.73
37	Hs.446698	Basic leucine zipper transcription factor, ATF-like 2, BATF2	11q13.1		3.73
38	Hs.44155	Methylenetetrahydrofolate dehydrogenase 1-like, MTHFD1L	6q25.1		3.56
39	Hs.469358	KIAA1641	2q11.2		3.48
40	Hs.284266	Family with sequence similarity 127, member B, FAM127B	xq26.3		3.48
41	Hs.294144	Hypothetical protein FLJ21657, FLJ21657	5p12		3.40
42	Hs.55279	Serine(or cysteine) proteinase inhibitor, clade B member 5, SERPINB5	18q21.3		3.36
43	Hs.283085	Protocadherin beta 6, PCDHB6	5q31		3.25
44	Hs.91662	KIAA0888 protein, KIAA0888	5q13.3		3.03
45	Hs.171466	Elongation factor RNA polymerase II-like 3, ELL3	15q15.3		3.03
46	Hs.221974	Synaptosomal-associated protein, 25 kDa, SNAP25	20p12-p11.2		2.89
47	Hs.188662	KIAA1702 protein, KIAA1702	6p11		2.83
48	Hs.83450	Laminin, alpha 3, LAMA3	18q11.2		2.60
49	Hs.425352	F-box protein 17, FBXO17	19q13.2		2.30
50	Hs.390427	Immunoglobulin kappa variable 1D-13, IGKV1D-13	2p12		2.30
51	Hs.31442	RecQ protein-like 4, RECQL4	8q24.3		2.14
52	Hs.235368	Collagen, type V, alpha 3, COL5A3	19p13.2		2.05
53	Hs.24970	RAB39B, member RAS oncogene family, RAB39B	xq28		2.00

表2 在肝炎、肝硬化、肝癌中共同下调表达的基因

编号	Gene代码	基因描述	染色体定位	比值
1	Hs.75678	FBJ murine osteosarcoma viral oncogene homolog B, FOSB	19q13.32	0.067
2	Hs.8373	Chromosome 5 open reading frame 27, C5orf27	5q15	0.067
3	Hs.83623	X(inactive)-specific transcript, XIST	xq13.2	0.075
4	Hs.282409	Cytochrome P450, family 2, subfamily C, polypeptide 19, CYP2C19	10q24.1-q24.3	0.082
5	Hs.110	Solute carrier family 3 member 1, SLC3A1	2p16.3	0.102
6	Hs.532933	Purinergic receptor P2Y, G-protein coupled, 12, P2RY12	3q24-q25	0.177
7	Hs.1321	Coagulation factor XII, F12	5q33-qter	0.189
8	Hs.82120	Nuclear receptor subfamily 4, group A, member 2, NR4A2	2q22-q23	0.198
9	Hs.25647	V-fos FBJ murine osteosarcoma viral oncogene homolog, FOS	14q24.3	0.203
10	Hs.534337	Major histocompatibility complex, class II, DR beta 4, HLA-DRB4	6p21.3	0.250
11	Hs.332053	Serum amyloid A1, SAA1	11p15.1	0.287
12	Hs.9701	Growth arrest and DNA-damage-inducible, gamma, GADD45G	9q22.1-q22.2	0.308
13	Hs.1395	Early growth response 2, EGR2	10q21.1	0.330
14	Hs.388674	Heart alpha-kinase, HAK	18q21.31	0.354
15	Hs.171695	Dual specificity phosphatase 1, DUSP1	5q34	0.366
16	Hs.414795	Serine (or cysteine) proteinase inhibitor clade E member 1, SERPINE1	7q21.3-q22	0.379
17	Hs.8364	Pyruvate dehydrogenase kinase, isoenzyme 4, PDK4	7q21.3-q22.1	0.420
18	Hs.156637	Cas-Br-M ecotropic retroviral transforming sequence c, CBLC	19q13.2	0.435
19	Hs.76422	Phospholipase A2, group IIA (platelets, synovial fluid), PLA2G2A	1p35	0.435
20	Hs.1581	Glutathione S-transferase theta 2, GSTT2	22q11.23	0.435
21	Hs.30246	Solute carrier family 19 (thiamine transporter), member 2, SLC19A2	1q23.3	0.451
22	Hs.177534	Dual specificity phosphatase 10, DUSP10	1q41	0.451
23	Hs.9914	Follistatin, FST	5q11.2	0.456
24	Hs.74088	Early growth response 3, EGR3	8p23-p21	0.467
25	Hs.144287	Hairy/enhancer-of-split related with YRPW motif 2, HEY2	6q22.2-q22.33	0.467
26	Hs.351344	Transmembrane protein 25, TMEM25	11q23.3	0.467
27	Hs.249441	WEE1 homolog (S. pombe), WEE1	11p15.3-p15.1	0.483
28	Hs.376206	Kruppel-like factor 4 (gut), KLF4	9q31	0.483