基础研究
Copyright ©The Author(s) 2008.
世界华人消化杂志. 2008-05-18; 16(14): 1487-1492
在线出版 2008-05-18. doi: 10.11569/wcjd.v16.i14.1487
表1 部分基因差异表达的时段特点
基因GenBank IDSignal Log Ratio
4 wk8 wk20 wk
Akt3NM_011785---
MetNM_008591---
OtcNM_008769---
Alb1NM_0096549.77--
Mup1NM_03118821.88--
ApohNM_0134756.59--
RrasNM_009101-2.72-
SkiNM_011385-4.86-
Frat2NM_177603-2.59-
Ets1NM_011808--7.54
FgrA130081E08--2.55
KitNM_021099--2.71
MafaNM_194350--2.8
MosNM_020021--4.62
Mybl2NM_008652--2.39
RelNM_009044--5.8
Bcl26030439K11--12.46
BrafAK036798--5.46
Cdk2NM_183417--3.00
DnttNM_009345--29.08
PlgNM_008877--6.57
Sod1AK080908--109.38
CrklNM_007764-2.313.80
FosNM_010234-15.8410.52
MaffNM_010755-32.5322.96
MafkNM_010757-14.2411.20
MafgNM_010756-2.173.11
MybNM_033597-9.4218.64
Araf1200013E08-8.4014.80
Kras2NM_021284-13.7755.81
MrasNM_008624-16.0016.46
NrasNM_010937-9.8314.42
SrcNM_009271-2.403.46
YesNM_009535-2.7010.42
Abl1NM_009594-19.1312.46
CrkNM_1336562.1038.4057.81
JunbNM_0084163.5616.4983.45
JunNM_0105916.27169.9594.38
MycNM_0108492.3455.9337.98
Raf1NM_0297802.3685.8674.91
表2 部分差异表达显著的基因
基因GenBank IDSignal Log Ratio
4 wk8 wk20 wk
Rab5aNM_0258872.5956.35102.30
Rab11aNM_0173822.3255.2372.80
Raf1NM_0297802.3685.8674.91
Hras1NM_0082844.5389.7087.69
Rab6NM_0242874.2572.04101.41
Rab14NM_02669711.70346.95248.19
Rab7NM_0090054.56193.14258.92
MafbNM_0106580.000.00990.00
Rab3d6720486C030.0020.7614.86
Rab2NM_0215180.0040.2858.38
Vav3NM_1461390.0028.0042.46
Rab346430710G150.0030.4832.74
Rab10NM_0166760.0031.3340.31
Rab8aNM_0231260.0036.0039.76
Rab11bNM_0089970.0059.4733.87
Akt1NM_0096520.0065.7845.00
RalaNM_0194912.1870.56100.05
Hras1NM_0082844.5389.7087.69
Calm4NM_0200363.49548.92784.20
Calm2NM_00758911.36472.14847.66
CycsNM_00780817.10169.20336.39
Mt4NM_0086317.6987.6177.89
Snx1NM_0197274.4876.10139.85
Ccnh1810059M176.3267.67102.66
Psmc6NM_02595922.00274.501134.35
Eif2s22700038J2224.80393.751761.23
Creg1600000E1722.001457.101430.31
Pts0610012K150.00392.40558.00
FthNM_01023914.24807.34319.01
Cab39NM_1337812.89245.9 0115.46
表3 部分抑癌基因的差异表达
基因GenBank IDSignal Log Ratio
4 wk8 wk20 wk
Brca1NM_0097640.000.003.31
Brca2NM_0097650.006.6415.92
PtenNM_0089600.0036.3838.08
ApcNM_0074620.000.003.05
Ptch1NM_0089570.000.002.85
DccNM_0078310.000.008.11
表4 甲基化酶基因的差异表达
基因GenBank IDSignal Log Ratio
4 wk8 wk20 wk
Dnmt1NM_0100660.005.656.80
Dnmt2NM_0100670.002.114.15
Dnmt3aG431002P100.000.000.00
Dnmt3bNM_0100680.000.000.00
表5 去甲基酶基因的差异表达
基因GenBank IDSignal Log Ratio
4 wk8 wk20 wk
Mbd2NM_0107730.002.294.00
Gadd45aNM_0078362.9156.7065.47
表6 乙酰化修饰相关基因的差异表达
基因GenBank IDSignal Log Ratio
4 wk8 wk20 wk
Hdac2NM_0082290.000.0015.23
Hdac10NM_1991980.0020.1425.79
Hdac7aNM_0195720.000.003.76
Hdac5NM_0104120.0040.7421.21
Hdac3NM_0104110.005.826.65
Hdac1NM_0082280.004.325.17
Hdac11NM_1449190.000.000.00
Hdac6NM_0104130.000.002.58

引文著录: 吴强强, 魏亚宁, 张素珍, 舒青. 亚硝胺诱导食管癌变早期基因差异表达与表观遗传修饰的关系. 世界华人消化杂志 2008; 16(14): 1487-1492