人胃癌顺铂耐药细胞系的建立过程

表1 SGC7901与SGC7901/DDP细胞的耐药性

t	细胞	DDP	5-FU	MMC	VCR	ADM
0 mo IC50(g/L)	SGC7901	0.244	0.432	0.149	0.196	0.102
	SGC7901/DDP	0.279	0.421	0.157	0.210	0.096
	RI	1.1	1.0	1.0	1.0	0.9
1 mo IC50(g/L)	SGC7901	0.265	0.551	0.163	0.091	0.213
	SGC7901/DDP	0.564	0.954	0.213	0.098	0.256
	RI	2.1	1.7	1.3	1.1	1.2
2 mo IC50(gL)	SGC7901	0.255	0.562	0.143	0.101	0.250
	SGC7901/DDP	1.356	1.151	0.421	0.133	0.621
	RI	5.3	2.0	2.9	1.3	2.5
3 mo IC50(g/L)	SGC7901	0.199	0.466	0.244	0.221	0.332
	SGC7901/DDP	2.521	1.596	0.658	0.253	0.724
	RI	12.6	3.4	2.7	1.1	2.2
4 mo IC50(g/L)	SGC7901	0.231	0.324	0.196	0.354	0.168
	SGC7901/DDP	2.986	1.624	0.965	0.413	0.814
	RI	12.9	5.0	4.9	1.2	4.8

表2 SGC7901与SGC7901/DDP细胞的周期分布(%)

细胞系	G0/G1	S	G2/M
SGC7901	49.6	26.5	23.9
SGC7901/DDP 1 mo	50.2	25.3	22.1
SGC7901/DDP 2 mo	52.7	25.4	20.8
SGC7901/DDP 3 mob	59.6	24.9	14.6
SGC7901/DDP 4 mob	61.5	24.7	13.8

^bP<0.01 vs SGC7901.