临床研究
Copyright ©The Author(s) 2007.
世界华人消化杂志. 2007-04-08; 15(10): 1096-1102
在线出版 2007-04-08. doi: 10.11569/wcjd.v15.i10.1096
表1 MTA1, PTEN, E-cadherin在正常胃组织及胃癌组织中的表达
项目nMTA1
PPTEN
PE-cadherin
P
阴性阳性阴性阳性异常正常
实验组5429(53.7%)25(46.3%)0.00526(48.1%)28(51.9%)0.00131(57.4%)23(42.6%)0.000
对照组1514(93.3%)1(6.7%)0(0.0%)15(100.0%)0(0.0%)15(100.0%)
表2 MTA1, PTEN, E-cadherin在胃癌组织中的表达与病理因素的关系
项目nMTA1
PPTEN
PE-cadherin
P
阴性阳性阴性阳性异常正常
浸润深度0.0030.0010.027
浆膜下1513(86.7%)2(13.3%)2(13.3%)13(86.7%)5(33.3%)10(66.7%)
浸透浆膜3916(41%)23(59%)24(61.5%)15(38.5%)26(66.7%)13(33.3%)
分化0.0040.0080.006
1914(73.7%)5(26.3%)7(36.8%)12(63.2%)6(31.6%)13(68.4%)
1711(64.7%)6(35.3%)5(29.4%)12(70.6%)10(58.8%)7(41.2%)
184(22.2%)14(77.8%)14(77.8%)4(22.2%)15(83.3%)3(16.7%)
淋巴转移0.0000.0010.044
2922(75.9%)7(24.1%)8(27.6%)21(72.4%)13(44.8%)16(55.2%)
257(28.0%)18(72.0%)18(72.0%)7(28.0%)18(72.0%)7(28.0%)
远隔转移0.0040.0060.941
4227(64.3%)15(35.7%)16(38.1%)26(61.9%)24(57.1%)18(42.9%)
122(16.7%)10(83.3%)10(83.3%)2(16.7%)7(58.3%)5(41.7%)
TNM分期10.0010.0000.000
Ⅰ+Ⅱ2620(76.9%)6(23.1%)6(23.1%)20(76.9%)8(30.8%)18(69.2%)
Ⅲ+Ⅳ289(32.1%)19(67.9%)20(71.4%)8(28.6%)23(82.1%)5(17.9%)
性别0.6090.4870.653
3719(51.4%)18(48.6%)19(51.4%)18(48.6%)22(59.5%)15(40.5%)
1710(58.8%)7(41.2%)7(41.2%)10(58.8%)9(52.9%)8(47.1%)
年龄0.6520.3940.902
<60岁2412(50.0%)12(50.0%)10(41.7%)14(58.3%)14(58.3%)10(41.7%)
≥60岁3017(56.7%)13(43.3%)16(53.3%)14(46.7%)17(56.7%)13(43.3%)
肿瘤大小0.5070.0990.297
<5 cm3721(56.8%)16(43.2%)15(40.5%)22(59.5%)23(62.2%)14(37.8%)
≥5 cm178(47.1%)9(52.9%)11(64.7%)6(35.3%)8(47.1%)9(52.9%)
表3 胃癌组织中MTA1与PTEN, E-cadherin的表达的相关性
项目PTEN的表达
PrsE-cadherin的表达
Prs
阴性阳性异常正常
MTA1的表达
阴性722<0.001-0.5181118<0.01-0.424
阳性196205
表4 胃癌组织中PTEN和E-cadherin的表达的相关性
项目E-cadherin的表达
Prs
异常正常
PTEN的表达
阴性224<0.0010.53
阳性919

引文著录: 桑海泉, 王强. 胃癌组织中MTA1, PTEN, E-cadherin的表达及其相互关系. 世界华人消化杂志 2007; 15(10): 1096-1102