比较基因组杂交技术: 贲门癌和淋巴结转移灶的染色体变化特征

表1 贲门癌CGH结果

Case Number	Gains	Losses
57	6p21-6q13, 16p11-16q21, 20	1pter-1p31, 17, 19
195	4, 5p, 7pter-7q31, 8q11-8q23, 13	1pter-1p31, 1p13-1q21, 9q, 14, 15, 17pter-17q21, 19, 22
216	1q, 5p, 6p, 7, 8q, 16p11-16q21, 20	1pter-1p22.3, 4, 19, 21
236	5p14-5q32, 6q13-6q24, 7q21-31	1pter-1p33, 6p, 17p, 19, 22
01-637	5p, 6, 7pter-7q31, 8q, 20	1pter-1p22, 8p, 12q21-12qter, 16
16176	3q, 6p21-6qter, 8q, 10p, 11q11-q23.3, 11q14-11q23, 14	4q, 9p12-9pter, 13, Y
L16176	1q, 3q, 6, 7, 8, 11p11-11q23, 11q14-11q23, 14	3p, 4, 9p13-9qter, 13
16178	5, 12pter-12q23, 12p12-11, 12q13-12q23 16p11-16q13, 20	6p, 9q, 19
16607	8q12-8qter	1pter-31, 17, 19
16661	1p13-1q23, 6q13-6qter, 8q, 11p, 11q13-11qter, 13, 18q12-18qter, 20p12-20qter	4p, 5p, 8p, 12pter-12q13, 16p, 17p
L16661	1p13-1qter, 1p13-1q21, 5p, 6p12-6q15, 8q, 10p11-10q21, 11pter-11p12, 11q13-11qter, 13, 18, 20	4, 7p12-7qter, 8p, 9, 12q22-12qter, 16p, 17p
16689	1q12-1q31, 18p	4, 6p, 17, 19
16699	20	19p
16736	6p21-6qter, 8p, 12q14-12q21, 18	1pter-1p32, 3p, 14, 16, 17, 19, 22
16737	1p13-1q23, 6p22-6q13, 7, 9p13-9q22, 9p12-9q21, 10pter-10q25, 15	1pter-1p21, Y
16717	2q31-2q33, 3q24-3qter, 4p12-4q13, 7, 8q, 11p14-11p11	1pter-1p31, 5q, 13, 14, 17, 19
16724	2pter-2p21, 3q23-3q26, 5p14-5q12, 7, 8	1pter-1p31, 17p, 19p, 21, 22
16726	1q21-31, 3q24-3q26, 7q11-7q33, 8, 9, 20	1pter-1p31, 2, 3p, 4, 6pter-6q14, 10q, 18, Y
L16726	2pter-2p22, 4p12-4q13, 16p11-16q21, 20	1pter-1p31, 18
16749	2p16-2q33, 3, 7p, 8p11-8qter, 12pter-12q13, 13, 20q	1pter-1p33, 16, 17, 18, 19p, 21
L16749	2p16-2q33, 3p13-3qter, 7, 8q, 12p, 13, 20q12-20qter	1pter-1p33, 11p12-11q14, 12q21-12qter, 16, 17pter-17q12, 18, 19p, 21, 22
16777	10, 15pter-15q15, 16p12-16q21, 20
L16777	1q32-1qter, 3, 8pter-8q23, 10, 11pter-11q13, 15pter-15q15, 20, 20q12-qter	9p12-9qter, 11q21-11qter, 17p11-17qter
16791	3p12-3qter, 3q24-3q26	19
19114	1q22-1qter, 3, 6, 7, 11q23-11qter, 12qter-12q12, 13, 16p	1pter-1p33, 2q14-2qter, 16q, 17, 19, X
16348	6p12-6q14, 13	17
19146	3q, 9q22-9qter, 15, 18, 20
19419	2q14-2qter, 3q21-24, 5p, 6q, 8pter-8p12, 10, 11q13-11q14, 12, 13, 20	3p21-3p11, 11p12-11q12, 16, 17
21113	7q21-33	3pter-3p24, 6pter-6p22, 7q34-7qter
21116	16p11-16q13	5pter-5p14, 6p, 6q23-6qter
L21116	16p11-16q21	6p, 14, 16q22-16qter
21127	6p21-6q13, 12p12-12q13
21143	8p22-8qter, 10q22-10qter, 13, 16p11-16q21, 17p11-17qter, 20	1p, 2pter-2p14, 3p, 4p, 5q14-5q31, 9pter-9q21, 17p, 21
21158		4q26-4qter, 9p12-9qter
21159	1p13-1q21, 16p11-16q13	1pter-1p32, 6q, 9p, 10p, 12q, 14, 17, X
21163	1p11-1q22, 5pter-5q12, 6p12-6q13, 16p11-16q13, 18, 20pter-20q11	4, 5q, 8p, 17, 18q, 19
21184	1p31-1q31	11q
L21184	6p, 7pter-7q31, 8p12-8qter, 13, 17p	4, 5pter-5p14, 7q32-7qter, 9p

表2 贲门癌CGH增加和丢失的频率

Chromosome Number	Gain site	Rate	Loss site	Rate
1	1q+	9/30(30%)	1p-	14/30(47%)
3	3q+	5/30(17%)	3p-	9/30(30%)
4			4p-	6/30(20%)
5	5p+	6/30(20%)	5q-	3/30(10%)
6	6q+	12/30(40%)
7	7p+	10/30(33%)
8	8q+	11/30(37%)	8p-	3/30(10%)
9			9q-	5/30(17%)
12	12p+	5/30(17%)
13	13q+	7/30(23%)	13q-	2/30(7%)
17			17p-	17/30(57%)
18	18q+	4/30(13%)
18	18p+	4/30(13%)
19			19p-	15/30(50%)
20	20q+	13/30(43%)