Effects of low-calorie diet on steatohepatitis in rats with obesity and hyperlipidemia

Table 1 Changes of body weight and liver index

Groups	n	Body weight/g	Liver index 100%	Abdominal adipose/g
Control	9	351.1 ± 43.0	2.957 ± 0.301	9.54 ± 1.43
NASH	10	423.5 ± 65.2a	3.784 ± 0.533b	14.25 ± 1.86a
LCD	10	329.5 ± 38.4c	3.199 ± 0.552d	10.21 ± 1.52d

^aP < 0.05,

^bP < 0.01 vs control.

^cP < 0.01,

^dP < 0.05 vs NASH group.

Table 2 Changes of major plasma lipid parameters

Groups	n	TG mmol/L	TCH mmol/L	FFA mmol/L
Control	9	0.63 ± 0.22	1.27 ± 0.17	429.2 ± 96.7
NASH	10	0.62 ± 0.10	1.60 ± 0.41a	728.2 ± 178.5b
LCD	10	0.39 ± 0.13c	2.04 ± 0.50d	771.3 ± 124.4

^aP < 0.05,

^bP < 0.01 vs control.

^cP < 0.001,

^dP < 0.05 vs NASH group.

Table 3 Alternations of some biochemical variables in rat liver function

Groups	n	ALT nkat/L	AST nkat/L	A g/L	A/G
Control	9	671.34 ± 118.57	1648.29 ± 414.16	25.13 ± 4.61	0.71 ± 0.11
NASH	10	1257.51 ± 671.34a	2760.51 ± 998.66b	27.40 ± 2.04	0.73 ± 0.08
LCD	10	683.03 ± 245.49c	2344.68 ± 539.41	24.51 ± 4.69	0.71 ± 0.16

^aP < 0.05,

^bP < 0.01 vs control.

^cP < 0.05 vs NASH group.

Table 4 Severity of hepatic steatosis in rats of different groups

Groups	n	-	+	++	+++
Control	9	9
NASH	10		3	6	1
LCD	10	3	5	2

Rank sum test: P < 0.05.