Copyright ©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 7, 2010; 16(45): 5651-5661
Published online Dec 7, 2010. doi: 10.3748/wjg.v16.i45.5651
Table 1 Results of population-based studies showing liver toxicity induced by non-steroidal anti-inflammatory drugs
AuthorsStudy designIncidence rate of hepatotoxicity (ALT ≥ 3 ULN) per 100 000 patient-years (95% CI)
García Rodríguez et al[22], 1992Retrospective cohort study, cross over design9/100 000 (6-15)
Traversa et al[23], 2003Retrospective cohort1.4/100 000 (1.0-2.1)
de Abajo et al[24], 2004Retrospective population-based case-control study2.4/100 000 (2.0-2.8)
Rubenstein et al[26], 2004Systematic review (hospitalization or death)3.1 to 23.4/100 000
Rostom et al[21], 2005Systematic review0.29/100 000 (0.17-0.51)
Laine et al[25], 2009Long-term prospective trial2.1/100 000 (1.9-2.3)
Table 2 Liver-related hepatotoxicity induced by non-steroidal anti-inflammatory drugs
DrugPattern of liver damageProposed mechanismIncidence
AspirinAcute and chronic hepatitisDose dependentLow
Reye’s syndrome> with high dose
DiclofenacAcute and chronic hepatitisMetabolicLow
Mixed damage and pure cholestasisImmunologic
SulindacAcute hepatitis and mixed injuryHypersensivityModerate
IbuprofenAcute hepatitis, ductopeniaMetabolicLow
NaproxenCholestatic, mixed damageMetabolicLow
CoxibsAcute hepatitis, mixed damageProbably metabolicLow
OxicamsAcute hepatitis, massive and submassive necrosis, cholestasis and ductopeniaMetabolicLow
NimesulideAcute hepatitis, pure cholestasisProbably metabolicModerate