Myelophil, a mixture of Astragali Radix and Salviae Radix extract, moderates toxic side effects of fluorouracil in mice

Table 1 Hematological effect of Myelophil on 5-FU-induced myelosuppression

Cells/groups		d 0	d 4	d 7	d 10	d 13
WBC (103 cells/&mgr;L)	Control	5.5 ± 1.2	2.3 ± 0.3	0.7 ± 0.2	2.0 ± 1.0	3.7 ± 1.5
	MP 50	5.5 ± 1.2	2.3 ± 0.9	1.2 ± 0.4a	2.5 ± 0.9	6.4 ± 1.6a
	MP100	5.5 ± 1.2	2.4 ± 0.3	1.6 ± 0.4b	2.9 ± 0.6	4.2 ± 1.0a
RBC (106 cells/&mgr;L)	Control	7.1 ± 0.8	7.3 ± 0.6	5.3 ± 0.2	6.3 ± 1.2	7.0 ± 1.0
	MP 50	7.1 ± 0.8	6.3 ± 0.6a	5.9 ± 0.4b	6.9 ± 0.7	6.9 ± 1.2
	MP 100	7.1 ± 0.8	6.6 ± 0.5	6.6 ± 0.4b	6.7 ± 0.5	7.2 ± 1.0
Platelets (105 cells/&mgr;L)	Control	13.8 ± 0.8	8.5 ± 1.3	5.3 ± 1.5	7.3 ± 1.7	12.0 ± 5.3
	MP 50	13.8 ± 0.8	8.8 ± 1.3	8.2 ± 1.4a	9.1 ± 3.2	17.7 ± 6.6
	MP 100	13.8 ± 0.8	9.8 ± 1.8	9.0 ± 2.2a	10.9 ± 4.5	16.2 ± 4.9

From 2 d after 5-FU injection, Myelophil (0.05 g/kg or 0.1 g/kg) or distilled water (for the control group) was given to mice for 10 d. On day 0, 4, 7, 10 and 13, complete blood counts were analyzed using a blood cell counter. Data are expressed as mean ± SD (n = 5).

^aP < 0.05,

^bP < 0.01 vs control group. MP: Myelophil.