Copyright ©The Author(s) 1999.
World J Gastroenterol. Feb 15, 1999; 5(1): 64-72
Published online Feb 15, 1999. doi: 10.3748/wjg.v5.i1.64
Table 4 Immunosuppressives used in inflammatory bowel diseases
DrugMode of actionMechanism of action
AZT/6-MPInhibition of ribonucleotide sysnthesisInhibition of proliferation of T-cell clones
MethotrexateFolic acid inhibitorInhibition of T and B-cell
Function decrease of IL-1 and IL-6
Cyclosporin (CsAInhibition of T-cell-receptor-stimulatedInhibition of IL-2 production and
Tacolimua (FK 506)Transcription of lymphokine genesIL-2 receptors; inhibition of cytokines(TNFα, IFNγ)
MycophenolateInhibition of guanosin nucleotide synthesis